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    Shisa5 shisa family member 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301013, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Shisa5provided by RGD
    Official Full Name
    shisa family member 5provided by RGD
    Primary source
    RGD:1359661
    See related
    EnsemblRapid:ENSRNOG00000020667 AllianceGenome:RGD:1359661
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable WW domain binding activity. Predicted to be involved in positive regulation of canonical NF-kappaB signal transduction. Predicted to act upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Predicted to be located in endoplasmic reticulum and nuclear envelope. Orthologous to human SHISA5 (shisa family member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 248.7), Lung (RPKM 169.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Shisa5 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (118569975..118584880)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (109691504..109706411)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (117780992..117795923)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 Neighboring gene uncharacterized LOC100911671 Neighboring gene uncharacterized LOC134480237 Neighboring gene three prime repair exonuclease 1 Neighboring gene ATR interacting protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane. Bourdon JC, et al. J Cell Biol, 2002 Jul 22. PMID 12135983, Free PMC Article
    2. WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins. Ludes-Meyers JH, et al. Oncogene, 2004 Jun 24. PMID 15064722, Free PMC Article
    3. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Matsuda A, et al. Oncogene, 2003 May 22. PMID 12761501
    4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94600

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables WW domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein shisa-5
    Names
    scotin
    shisa homolog 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006989.1 → NP_001006990.1  protein shisa-5 isoform 4

      See identical proteins and their annotated locations for NP_001006990.1

      Status: VALIDATED

      Source sequence(s)
      BC083710
      UniProtKB/Swiss-Prot
      Q5XIH2
      UniProtKB/TrEMBL
      A6I3A7, A6I3A9
      Related
      ENSRNOP00000053045.2, ENSRNOT00000056199.4
      Conserved Domains (1) summary
      pfam13908
      Location:2 → 86
      Shisa; Wnt and FGF inhibitory regulator

    2. NM_001395736.1 → NP_001382665.1  protein shisa-5 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A0G2K447
      Related
      ENSRNOP00000072905.3, ENSRNOT00000077236.3
      Conserved Domains (1) summary
      pfam13908
      Location:38 → 201
      Shisa; Wnt and FGF inhibitory regulator

    3. NM_001395737.1 → NP_001382666.1  protein shisa-5 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A0G2K447, A6I3A3
      Conserved Domains (1) summary
      pfam13908
      Location:38 → 200
      Shisa; Wnt and FGF inhibitory regulator

    4. NM_001395738.1 → NP_001382667.1  protein shisa-5 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A0G2K447
      Related
      ENSRNOP00000108466.1, ENSRNOT00000150153.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      118569975..118584880
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243762.5 → XP_006243824.1  protein shisa-5 isoform X1

      See identical proteins and their annotated locations for XP_006243824.1

      UniProtKB/TrEMBL
      A6I3A8, A6I3B0
      Related
      ENSRNOP00000109797.1, ENSRNOT00000143504.1
      Conserved Domains (1) summary
      pfam13908
      Location:14 → 98
      Shisa; Wnt and FGF inhibitory regulator
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIH2.1 GenPept UniProtKB/Swiss-Prot:Q5XIH2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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