Celf1 CUGBP, Elav-like family member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Celf1provided by RGD
Official Full Name: CUGBP, Elav-like family member 1provided by RGD
Primary source: RGD:1307721
See related: EnsemblRapid:ENSRNOG00000010379 AllianceGenome:RGD:1307721
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cugbp1
Summary: Enables mRNA 3'-UTR binding activity. Involved in cellular response to polyamine macromolecule; negative regulation of epithelial cell proliferation; and post-transcriptional regulation of gene expression. Acts upstream of or within positive regulation of gene expression. Predicted to be located in cytoplasmic stress granule and nucleus. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human CELF1 (CUGBP Elav-like family member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 191.2), Thymus (RPKM 163.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q24

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (97380407..97455253)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (76924591..76999429)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (79768900..79844548)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A sustained suppression of IEC proliferation evoked by CELF1/p53 axis.
Title: CELF1/p53 axis: a sustained antiproliferative signal leading to villus atrophy under total parenteral nutrition.
demonstrated that CUGBP1 expression was positively correlated with PCNA expression, and the p27 expression was negatively correlated with CUGBP1 expression following LPS stimulation
Title: The Expression of CUGBP1 After Spinal Cord Injury in Rats.
These findings identify miR-503 as both a novel regulator of CUGBP1 expression and a modulator of intestinal epithelial homoeostasis
Title: miR-503 represses CUG-binding protein 1 translation by recruiting CUGBP1 mRNA to processing bodies.
polyamine-regulated CUG-binding protein 1 and miR-222 modulate cyclin-dependent kinase 4 (CDK4) translation at least in part by altering the recruitment of CDK4 mRNA to processing bodies
Title: Regulation of cyclin-dependent kinase 4 translation through CUG-binding protein 1 and microRNA-222 by polyamines.
CUG-BP1 and HuR act as factors that bind to the SBP2 3' UTR, which suggests that TTR-RBPs play a role in the regulation of SBP2
Title: Known turnover and translation regulatory RNA-binding proteins interact with the 3' UTR of SECIS-binding protein 2.
CUG triplet repeat-binding protein-1 has a role in adipogenesis with aging
Title: Increased CUG triplet repeat-binding protein-1 predisposes to impaired adipogenesis with aging.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH133857 (e-PCR)
- UniSTS:217140

Cugbp1 (e-PCR), detects polymorphism
- UniSTS:479088

X61451 (e-PCR)
- UniSTS:125827

RH125691 (e-PCR)
- UniSTS:162464

MARC_7541-7542:996687927:1 (e-PCR)
- UniSTS:269790

MARC_11599-11600:1002739035:1 (e-PCR)
- UniSTS:267239

AA997594 (e-PCR)
- UniSTS:261112

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables BRE binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables lncRNA binding	IEA Inferred from Electronic Annotation more info
enables lncRNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables pre-mRNA binding	ISO Inferred from Sequence Orthology more info
enables translation initiation factor binding	IEA Inferred from Electronic Annotation more info
enables translation initiation factor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in cellular response to polyamine macromolecule	IEP Inferred from Expression Pattern more info	PubMed
involved_in cerebral cortex development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cerebral cortex development	ISO Inferred from Sequence Orthology more info
involved_in mRNA destabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splice site recognition	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splice site recognition	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA splice site recognition	ISO Inferred from Sequence Orthology more info
involved_in mRNA splice site recognition	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of multicellular organism growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in post-transcriptional gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-transcriptional gene silencing	ISO Inferred from Sequence Orthology more info
involved_in regulation of RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in regulation of RNA splicing	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
acts_upstream_of regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in spermatid development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spermatid development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in male germ cell nucleus	IEA Inferred from Electronic Annotation more info
located_in male germ cell nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinucleolar compartment	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: CUGBP Elav-like family member 1

Names: CELF-1; CUG triplet repeat RNA-binding protein 1; CUG-BP- and ETR-3-like factor 1; CUG-BP1; RNA-binding protein BRUNOL-2; bruno-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025421.3 → NP_001020592.1 CUGBP Elav-like family member 1 isoform e

See identical proteins and their annotated locations for NP_001020592.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q4QQT3

UniProtKB/TrEMBL

A0A8I5ZTX3, A0A8I6AL51

Related

ENSRNOP00000080849.2, ENSRNOT00000106910.2

Conserved Domains (3) summary

cd12638
Location:395 → 486

RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

cd12631
Location:15 → 98

RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins

cd12634
Location:107 → 187

RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
NM_001434316.1 → NP_001421245.1 CUGBP Elav-like family member 1 isoform a

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I5ZTX3, A0A8I6AL51
NM_001434317.1 → NP_001421246.1 CUGBP Elav-like family member 1 isoform b

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I5ZTX3, A0A8I6AL51, A6HN95
NM_001434318.1 → NP_001421247.1 CUGBP Elav-like family member 1 isoform c

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I5ZTX3, A0A8I6AL51
NM_001434319.1 → NP_001421248.1 CUGBP Elav-like family member 1 isoform d

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I5ZTX3, A0A8I6AL51
NM_001434320.1 → NP_001421249.1 CUGBP Elav-like family member 1 isoform e

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q4QQT3

UniProtKB/TrEMBL

A0A8I5ZTX3, A0A8I6AL51
NM_001434321.1 → NP_001421250.1 CUGBP Elav-like family member 1 isoform f

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I5ZTX3, A0A8I6AL51, A6HN97
NM_001434322.1 → NP_001421251.1 CUGBP Elav-like family member 1 isoform f

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I5ZTX3, A0A8I6AL51, A6HN97
NM_001434323.1 → NP_001421252.1 CUGBP Elav-like family member 1 isoform f

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I5ZTX3, A0A8I6AL51, A6HN97
NM_001434324.1 → NP_001421253.1 CUGBP Elav-like family member 1 isoform g

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I5ZTX3, A0A8I6AL51, A0A8L2Q6U8
NM_001434325.1 → NP_001421254.1 CUGBP Elav-like family member 1 isoform h

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I5ZTX3, A0A8I6AL51

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

97380407..97455253

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063284140.1 → XP_063140210.1 CUGBP Elav-like family member 1 isoform X2

UniProtKB/TrEMBL

A0A8I5ZTX3, A0A8I6AL51, A6HN95
XM_039105417.2 → XP_038961345.1 CUGBP Elav-like family member 1 isoform X4

UniProtKB/TrEMBL

A0A8I5ZTX3, A0A8I6AL51

Conserved Domains (3) summary

cd12638
Location:417 → 508

RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

cd12631
Location:42 → 125

RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins

cd12634
Location:134 → 214

RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
XM_039105419.2 → XP_038961347.1 CUGBP Elav-like family member 1 isoform X4

UniProtKB/TrEMBL

A0A8I5ZTX3, A0A8I6AL51

Conserved Domains (3) summary

cd12638
Location:417 → 508

RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

cd12631
Location:42 → 125

RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins

cd12634
Location:134 → 214

RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
XM_063284144.1 → XP_063140214.1 CUGBP Elav-like family member 1 isoform X4
XM_039105415.2 → XP_038961343.1 CUGBP Elav-like family member 1 isoform X2

Conserved Domains (3) summary

cd12638
Location:421 → 512

RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

cd12631
Location:42 → 125

RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins

cd12634
Location:134 → 214

RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
XM_039105411.2 → XP_038961339.1 CUGBP Elav-like family member 1 isoform X1

UniProtKB/TrEMBL

A0A8I5ZTX3, A0A8I6AL51

Related

ENSRNOP00000094511.2, ENSRNOT00000109347.2

Conserved Domains (3) summary

cd12638
Location:422 → 513

RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

cd12631
Location:42 → 125

RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins

cd12634
Location:134 → 214

RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
XM_039105414.2 → XP_038961342.1 CUGBP Elav-like family member 1 isoform X1

Conserved Domains (3) summary

cd12638
Location:422 → 513

RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

cd12631
Location:42 → 125

RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins

cd12634
Location:134 → 214

RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
XM_039105416.2 → XP_038961344.1 CUGBP Elav-like family member 1 isoform X3

UniProtKB/TrEMBL

A0A8I5ZTX3, A0A8I6AL51

Conserved Domains (3) summary

cd12638
Location:418 → 509

RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

cd12631
Location:42 → 125

RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins

cd12634
Location:134 → 214

RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
XM_063284142.1 → XP_063140212.1 CUGBP Elav-like family member 1 isoform X3

UniProtKB/TrEMBL

A0A8I5ZTX3, A0A8I6AL51

Related

ENSRNOP00000014484.7, ENSRNOT00000014484.9
XM_063284141.1 → XP_063140211.1 CUGBP Elav-like family member 1 isoform X3
XM_039105420.2 → XP_038961348.1 CUGBP Elav-like family member 1 isoform X5

UniProtKB/Swiss-Prot

Q4QQT3

UniProtKB/TrEMBL

A0A8I5ZTX3, A0A8I6AL51

Conserved Domains (3) summary

cd12638
Location:395 → 486

RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

cd12631
Location:15 → 98

RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins

cd12634
Location:107 → 187

RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
XM_063284146.1 → XP_063140216.1 CUGBP Elav-like family member 1 isoform X5

UniProtKB/Swiss-Prot

Q4QQT3

UniProtKB/TrEMBL

A0A8I5ZTX3, A0A8I6AL51
XM_039105412.2 → XP_038961340.1 CUGBP Elav-like family member 1 isoform X1

UniProtKB/TrEMBL

A0A8I5ZTX3, A0A8I6AL51

Conserved Domains (3) summary

cd12638
Location:422 → 513

RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

cd12631
Location:42 → 125

RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins

cd12634
Location:134 → 214

RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
XM_039105423.2 → XP_038961351.1 CUGBP Elav-like family member 1 isoform X5

UniProtKB/Swiss-Prot

Q4QQT3

UniProtKB/TrEMBL

A0A8I5ZTX3, A0A8I6AL51

Conserved Domains (3) summary

cd12638
Location:395 → 486

RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

cd12631
Location:15 → 98

RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins

cd12634
Location:107 → 187

RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
XM_063284145.1 → XP_063140215.1 CUGBP Elav-like family member 1 isoform X5

UniProtKB/Swiss-Prot

Q4QQT3

UniProtKB/TrEMBL

A0A8I5ZTX3, A0A8I6AL51
XM_063284149.1 → XP_063140219.1 CUGBP Elav-like family member 1 isoform X7

UniProtKB/TrEMBL

A0A8I5ZTX3, A0A8I6AL51, A0A8L2Q6U8
XM_039105422.2 → XP_038961350.1 CUGBP Elav-like family member 1 isoform X5

UniProtKB/Swiss-Prot

Q4QQT3

UniProtKB/TrEMBL

A0A8I5ZTX3, A0A8I6AL51

Conserved Domains (3) summary

cd12638
Location:395 → 486

RRM3_CELF1_2; RNA recognition motif 3 (RRM3) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins

cd12631
Location:15 → 98

RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins

cd12634
Location:107 → 187

RRM2_CELF1_2; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-1, CELF-2 and similar proteins
XM_063284147.1 → XP_063140217.1 CUGBP Elav-like family member 1 isoform X6

UniProtKB/TrEMBL

A0A8I5ZTX3, A0A8I6AL51, A6HN97

Related

ENSRNOP00000111254.1, ENSRNOT00000151133.1