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    Susd4 sushi domain containing 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289335, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Susd4provided by RGD
    Official Full Name
    sushi domain containing 4provided by RGD
    Primary source
    RGD:1564043
    See related
    EnsemblRapid:ENSRNOG00000003562 AllianceGenome:RGD:1564043
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564043
    Summary
    Predicted to be involved in negative regulation of complement activation, alternative pathway; negative regulation of complement activation, classical pathway; and regulation of postsynaptic neurotransmitter receptor internalization. Predicted to be active in parallel fiber to Purkinje cell synapse and postsynaptic membrane. Orthologous to human SUSD4 (sushi domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 112.1), Muscle (RPKM 8.8) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Susd4 in Genome Data Viewer
    Location:
    13q26
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (96982867..97109419)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (94455180..94577773)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (101181932..101307912)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene calpain 8 Neighboring gene coiled-coil domain containing 185 Neighboring gene uncharacterized LOC120096332 Neighboring gene small nucleolar RNA SNORD113/SNORD114 family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Sushi domain-containing protein 4 (SUSD4) inhibits complement by disrupting the formation of the classical C3 convertase. Holmquist E, et al. FASEB J, 2013 Jun. PMID 23482636
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in negative regulation of complement activation, alternative pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of complement activation, classical pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of complement activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynaptic neurotransmitter receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in parallel fiber to Purkinje cell synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sushi domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105982.1 → NP_001099452.1  sushi domain-containing protein 4

      See identical proteins and their annotated locations for NP_001099452.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473985
      UniProtKB/TrEMBL
      A0A8I6GG96, A6JGM6, D4A231
      Related
      ENSRNOP00000107157.1, ENSRNOT00000160532.1
      Conserved Domains (2) summary
      PHA02639
      Location:30 → 238
      PHA02639; EEV host range protein; Provisional
      smart00032
      Location:243 → 297
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      96982867..97109419
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272171.1 → XP_063128241.1  sushi domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GG96

    2. XM_039090566.2 → XP_038946494.1  sushi domain-containing protein 4 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GG96, A6JGM6, D4A231
      Related
      ENSRNOP00000045726.3, ENSRNOT00000052407.7
      Conserved Domains (2) summary
      PHA02639
      Location:30 → 238
      PHA02639; EEV host range protein; Provisional
      smart00032
      Location:243 → 297
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)

    3. XM_063272172.1 → XP_063128242.1  sushi domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GG96
    Nucleotide Protein Strain
    Heading Accession and Version

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