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    Suv39h1 SUV39H1 histone lysine methyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302553, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Suv39h1provided by RGD
    Official Full Name
    SUV39H1 histone lysine methyltransferaseprovided by RGD
    Primary source
    RGD:1565028
    See related
    EnsemblRapid:ENSRNOG00000039576 AllianceGenome:RGD:1565028
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Suv39h1l1; RGD1565028
    Summary
    Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; histone H3K9 trimethyltransferase activity; and histone H3K9me2 methyltransferase activity. Involved in response to amphetamine and response to nutrient levels. Predicted to be located in nucleolus and rDNA heterochromatin. Predicted to be part of eNoSc complex. Predicted to be active in nucleus. Biomarker of pre-malignant neoplasm. Orthologous to human SUV39H1 (SUV39H1 histone lysine methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 82.6), Spleen (RPKM 61.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Suv39h1 in Genome Data Viewer
    Location:
    Xq12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (17093059..17105942)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (14421028..14433993)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (15171280..15185191)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene WD repeat domain 13 Neighboring gene U6 spliceosomal RNA Neighboring gene WASP actin nucleation promoting factor Neighboring gene glyoxalase domain containing 5 Neighboring gene Annexin A7, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Contribution of the Suppressor of Variegation 3-9 Homolog 1 in Dorsal Root Ganglia and Spinal Cord Dorsal Horn to Nerve Injury-induced Nociceptive Hypersensitivity. Zhang J, et al. Anesthesiology, 2016 Oct. PMID 27483126, Free PMC Article
    2. Suv39h1 protects from myocardial ischemia-reperfusion injury in diabetic rats. Yang B, et al. Cell Physiol Biochem, 2014. PMID 24752040
    3. Gestational choline supply regulates methylation of histone H3, expression of histone methyltransferases G9a (Kmt1c) and Suv39h1 (Kmt1a), and DNA methylation of their genes in rat fetal liver and brain. Davison JM, et al. J Biol Chem, 2009 Jan 23. PMID 19001366, Free PMC Article
    4. Delta FosB mediates epigenetic desensitization of the c-fos gene after chronic amphetamine exposure. Renthal W, et al. J Neurosci, 2008 Jul 16. PMID 18632938, Free PMC Article
    5. Regulation of neuron survival and death by p130 and associated chromatin modifiers. Liu DX, et al. Genes Dev, 2005 Mar 15. PMID 15769944, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SUV39H augments intracellular reactive oxygen species levels in a SIRT1-dependent manner.
      Title: The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction.
    2. SUV39H1 plays a critical role in chromosome dynamics and development, neurite outgrowth, and ethanol-induced neuroadaptation through gene-specific silencing.
      Title: Contribution of the Suppressor of Variegation 3-9 Homolog 1 in Dorsal Root Ganglia and Spinal Cord Dorsal Horn to Nerve Injury-induced Nociceptive Hypersensitivity.
    3. Overexpression of Suv39h1 results in the de-activation of proinflammatory pathways and reduced apoptosis and myocardial injury.
      Title: Suv39h1 protects from myocardial ischemia-reperfusion injury in diabetic rats.
    4. Suv4-20h2 and Suv-39h1 histone methyltransferases are expressed and Histone H3 lysine 9 and H4 lysine 20 are trimethylated in hepatocarcinogenesis induced by methyl deficiency in rats [Suv4-20h2 and Suv-39h1]
      Title: Histone H3 lysine 9 and H4 lysine 20 trimethylation and the expression of Suv4-20h2 and Suv-39h1 histone methyltransferases in hepatocarcinogenesis induced by methyl deficiency in rats.
    5. SirT1 preserves heterochromatin structure: it modulates Suv39h1 protein levels in stress conditions by preventing MDM2-mediated polyubiquitination at K87.
      Title: Stabilization of Suv39H1 by SirT1 is part of oxidative stress response and ensures genome protection.
    6. mRNA and protein expression of histone methyltransferases G9a and Suv39h1 were directly related to the availability of choline
      Title: Gestational choline supply regulates methylation of histone H3, expression of histone methyltransferases G9a (Kmt1c) and Suv39h1 (Kmt1a), and DNA methylation of their genes in rat fetal liver and brain.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables S-adenosylmethionine-dependent methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H3K9 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K9 methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H3K9 trimethyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H3K9me2 methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within blastocyst hatching ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to glucose starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within determination of adult lifespan ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in energy homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epigenetic programming in the zygotic pronuclei ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression, epigenetic ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rDNA heterochromatin formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of bone mineralization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by glucose ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to amphetamine IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of chromatin silencing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eNoSc complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in heterochromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in rDNA heterochromatin ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase SUV39H1
    Names
    suppressor of variegation 3-9 homolog 1
    suppressor of variegation 3-9 homolog 1-like 1
    NP_001100426.1
    NP_001389376.1
    XP_063135989.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106956.2 → NP_001100426.1  histone-lysine N-methyltransferase SUV39H1 isoform 1

      See identical proteins and their annotated locations for NP_001100426.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I6AJD7, A6KP57
      Related
      ENSRNOP00000085857.2, ENSRNOT00000099546.2
      Conserved Domains (3) summary
      smart00468
      Location:133 → 228
      PreSET; N-terminal to some SET domains
      smart00317
      Location:244 → 367
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      pfam00385
      Location:45 → 92
      Chromo; Chromo (CHRromatin Organization MOdifier) domain

    2. NM_001402447.1 → NP_001389376.1  histone-lysine N-methyltransferase SUV39H1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I6AJD7, A0A9K3Y769, B1H256, G3V6S6
      Related
      ENSRNOP00000093302.1, ENSRNOT00000099347.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      17093059..17105942
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279919.1 → XP_063135989.1  histone-lysine N-methyltransferase SUV39H1 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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