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    Ccna2 cyclin A2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114494, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ccna2provided by RGD
    Official Full Name
    cyclin A2provided by RGD
    Primary source
    RGD:621059
    See related
    EnsemblRapid:ENSRNOG00000015423 AllianceGenome:RGD:621059
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity; protein domain specific binding activity; and protein kinase binding activity. Involved in several processes, including cellular response to cocaine; cellular response to estradiol stimulus; and cellular response to peptide hormone stimulus. Predicted to be located in cytosol; nucleoplasm; and pronucleus. Predicted to be part of cyclin A2-CDK1 complex and cyclin A2-CDK2 complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. Biomarker of myocardial infarction. Orthologous to human CCNA2 (cyclin A2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 275.4), Spleen (RPKM 179.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ccna2 in Genome Data Viewer
    Location:
    2q25
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (121355363..121361762, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (119427239..119433645, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (123274727..123282266, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 43 Neighboring gene exosome component 9 Neighboring gene Bardet-Biedl syndrome 7 Neighboring gene transient receptor potential cation channel, subfamily C, member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Decreased cyclin A2 and increased cyclin G1 levels coincide with loss of proliferative capacity in rat Leydig cells during pubertal development. Ge RS, et al. Endocrinology, 1997 Sep. PMID 9275057
    2. Increased levels of the FoxM1 transcription factor accelerate development and progression of prostate carcinomas in both TRAMP and LADY transgenic mice. Kalin TV, et al. Cancer Res, 2006 Feb 1. PMID 16452231, Free PMC Article
    3. Therapeutic delivery of cyclin A2 induces myocardial regeneration and enhances cardiac function in ischemic heart failure. Woo YJ, et al. Circulation, 2006 Jul 4. PMID 16820573
    4. Elevated levels and distinct patterns of expression of A-type cyclins and their associated cyclin-dependent kinases in male germ cell tumors. Liao C, et al. Int J Cancer, 2004 Feb 20. PMID 14696091
    5. Inhibition of anchorage-independent cell growth, adhesion, and cyclin D1 gene expression by a dominant negative mutant of a tyrosine phosphatase. Mitra SK, et al. Exp Cell Res, 2001 Oct 15. PMID 11597125

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SPINK3 along with Ccna2 and EGFR accelerated cell proliferation during rat liver regeneration via P38 MAPK, PKC, JAK-STAT and AKT pathways.
      Title: [SPINK3: A novel growth factor that promotes rat liver regeneration].
    2. Cyclin A2 might be involved in the modulation of rat cochlea development and cochlear stem cell differentiation.
      Title: Decreased level of cyclin A2 in rat cochlea development and cochlear stem cell differentiation.
    3. Fra-1 induction is important in thyroid tumorigenesis, critically regulating cyclin expression and cell-cycle progression.[Cyclin A]
      Title: Fra-1 promotes growth and survival in RAS-transformed thyroid cells by controlling cyclin A transcription.
    4. c-Jun is a mediator of the aberrant cyclin A2 expression associated with Ras/Src-induced transformation
      Title: Cyclin A is a c-Jun target gene and is necessary for c-Jun-induced anchorage-independent growth in RAT1a cells.
    5. leptin-induced decrease in cyclin A2 and subsequent increase in cyclin D1 expression precedes a leptin-triggered decrease in the number of prepubertal Leydig cells
      Title: Leptin-mediated decrease of cyclin A2 and increase of cyclin D1 expression: relevance for the control of prepubertal rat Leydig cell division and differentiation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156527

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in animal organ regeneration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cell cycle G1/S phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to cocaine IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to estradiol stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to insulin-like growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to leptin stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to luteinizing hormone stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to nitric oxide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to platelet-derived growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cochlea development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in positive regulation of DNA biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-translational protein modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to estradiol IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to glucagon IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cyclin A2-CDK1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cyclin A2-CDK2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cyclin A2-CDK2 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cyclin-dependent protein kinase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in female pronucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in male pronucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-A2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053702.3 → NP_446154.3  cyclin-A2

      See identical proteins and their annotated locations for NP_446154.3

      Status: VALIDATED

      Source sequence(s)
      AF367448, CK845133, CV114678, DY317814, DY551463
      UniProtKB/TrEMBL
      A0A0G2JVY9, A6IHY4
      Related
      ENSRNOP00000069674.2, ENSRNOT00000079745.3
      Conserved Domains (3) summary
      pfam00134
      Location:167 → 293
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:295 → 413
      Cyclin_C; Cyclin, C-terminal domain
      pfam16500
      Location:17 → 147
      Cyclin_N2; N-terminal region of cyclin_N

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      121355363..121361762 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008760903.4 → XP_008759125.1  cyclin-A2 isoform X2

      Conserved Domains (3) summary
      pfam00134
      Location:194 → 320
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:322 → 440
      Cyclin_C; Cyclin, C-terminal domain
      pfam16500
      Location:17 → 174
      Cyclin_N2; N-terminal region of cyclin_N

    2. XM_006232266.5 → XP_006232328.1  cyclin-A2 isoform X1

      UniProtKB/TrEMBL
      G3V802, Q6GX88
      Related
      ENSRNOP00000021156.5, ENSRNOT00000021156.8
      Conserved Domains (2) summary
      pfam00134
      Location:129 → 255
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:257 → 375
      Cyclin_C; Cyclin, C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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