Hlx H2.0-like homeobox [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hlxprovided by RGD
Official Full Name: H2.0-like homeoboxprovided by RGD
Primary source: RGD:1311961
See related: EnsemblRapid:ENSRNOG00000002309 AllianceGenome:RGD:1311961
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hlx1
Summary: Predicted to enable sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including embryonic digestive tract morphogenesis; enteric nervous system development; and regulation of T-helper cell differentiation. Predicted to be located in nucleus. Orthologous to human HLX (H2.0 like homeobox). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 82.2), Heart (RPKM 43.6) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q26

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (98811852..98817264, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (96280335..96285750, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (102637967..102643376, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of T-helper 1 cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of T-helper 2 cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within animal organ development	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic digestive tract morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within enteric nervous system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within liver development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of T-helper 2 cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of organ growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T-helper 1 cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of organ growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: H2.0-like homeobox protein

Names: H2.0-like homeo box 1; homeobox protein HLX1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077674.1 → NP_001071142.1 H2.0-like homeobox protein

See identical proteins and their annotated locations for NP_001071142.1

Status: PROVISIONAL

Source sequence(s)

BC127513

UniProtKB/Swiss-Prot

A0JPN1

UniProtKB/TrEMBL

A6JGP4

Related

ENSRNOP00000003155.3, ENSRNOT00000003155.7

Conserved Domains (2) summary

COG5576
Location:224 → 341

COG5576; Homeodomain-containing transcription factor [Transcription]

pfam00046
Location:276 → 330

Homeobox; Homeobox domain