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    Rpp30 ribonuclease P/MRP subunit p30 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 685332, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rpp30provided by RGD
    Official Full Name
    ribonuclease P/MRP subunit p30provided by RGD
    Primary source
    RGD:1595116
    See related
    EnsemblRapid:ENSRNOG00000018718 AllianceGenome:RGD:1595116
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ribonuclease P RNA binding activity. Predicted to contribute to ribonuclease P activity. Predicted to be involved in tRNA 5'-leader removal. Predicted to be part of nucleolar ribonuclease P complex and ribonuclease MRP complex. Orthologous to human RPP30 (ribonuclease P/MRP subunit p30). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 94.4), Thymus (RPKM 89.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rpp30 in Genome Data Viewer
    Location:
    1q53
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (243198647..243221559)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (233786048..233808958)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (254697247..254720093)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene 5-hydroxytryptamine receptor 7 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene uncharacterized LOC134485228 Neighboring gene uncharacterized LOC134485226 Neighboring gene uncharacterized LOC134485227 Neighboring gene ankyrin repeat domain 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Unexpected diversity of RNase P, an ancient tRNA processing enzyme: challenges and prospects. Lai LB, et al. FEBS Lett, 2010 Jan 21. PMID 19931535, Free PMC Article
    2. Differential association of protein subunits with the human RNase MRP and RNase P complexes. Welting TJ, et al. RNA, 2006 Jul. PMID 16723659, Free PMC Article
    3. Cryo-EM Structure of the Human Ribonuclease P Holoenzyme. Wu J, et al. Cell, 2018 Nov 15. PMID 30454648
    4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC187977

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribonuclease P RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to ribonuclease P activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in tRNA 5'-leader removal ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of multimeric ribonuclease P complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nucleolar ribonuclease P complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonuclease MRP complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ribonuclease P protein subunit p30
    Names
    ribonuclease P/MRP 30 subunit
    NP_001178012.1
    XP_038946870.1
    XP_063129955.1
    XP_063129956.1
    XP_063129957.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191083.1 → NP_001178012.1  ribonuclease P protein subunit p30

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6GJ86, D3ZU51
      Related
      ENSRNOP00000090910.1, ENSRNOT00000097535.2
      Conserved Domains (1) summary
      pfam01876
      Location:21 → 224
      RNase_P_p30; RNase P subunit p30

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      243198647..243221559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273887.1 → XP_063129957.1  ribonuclease P protein subunit p30 isoform X4

    2. XM_039090942.2 → XP_038946870.1  ribonuclease P protein subunit p30 isoform X2

      Conserved Domains (1) summary
      pfam01876
      Location:20 → 134
      RNase_P_p30; RNase P subunit p30

    3. XM_063273886.1 → XP_063129956.1  ribonuclease P protein subunit p30 isoform X3

    4. XM_063273885.1 → XP_063129955.1  ribonuclease P protein subunit p30 isoform X1

    RNA

    1. XR_005492259.2 RNA Sequence

    2. XR_005492258.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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