Tiam1 TIAM Rac1 associated GEF 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tiam1provided by RGD
Official Full Name: TIAM Rac1 associated GEF 1provided by RGD
Primary source: RGD:1307455
See related: EnsemblRapid:ENSRNOG00000021569 AllianceGenome:RGD:1307455
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables microtubule binding activity and receptor tyrosine kinase binding activity. Involved in several processes, including activation of GTPase activity; positive regulation of neurogenesis; and regulation of MAPK cascade. Located in several cellular components, including axon; dendritic spine; and ruffle membrane. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic density membrane. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with language delay and seizures. Orthologous to human TIAM1 (TIAM Rac1 associated GEF 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 116.8), Thymus (RPKM 34.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q11

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (42517527..42866280, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (29031347..29380153, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (29931083..30061173, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tiam1 plays a critical role in the development of glutamatergic perforant path-dentae gyrus synapses.
Title: Tiam1 is Critical for Glutamatergic Synapse Structure and Function in the Hippocampus.
We show that Rac1 and the Rac guanine nucleotide exchange factor (GEF) Tiam1 are differentially activated by oxygen-glucose deprivation in hippocampal and cortical neurons.
Title: Differential Tiam1/Rac1 activation in hippocampal and cortical neurons mediates differential spine shrinkage in response to oxygen/glucose deprivation.
our result suggests a critical role of NMDAR in regulation of oligodendrocyte precursor cells migration during CNS development by coupling to and activating the Tiam1/Rac1 pathway.
Title: NMDA receptor couples Rac1-GEF Tiam1 to direct oligodendrocyte precursor cell migration.
MAP1B interacts with a guanine exchange factor, termed Tiam1, which specifically activates Rac1.
Title: The light chain 1 subunit of the microtubule-associated protein 1B (MAP1B) is responsible for Tiam1 binding and Rac1 activation in neuronal cells.
Tiam1 mediates TrkA signaling and neurite outgrowth induced by NGF
Title: Tiam1 as a signaling mediator of nerve growth factor-dependent neurite outgrowth.
siRNA-mediated knock-down of Tiam1 markedly inhibited glucose-induced membrane trafficking and activation of Rac1.
Title: Regulatory roles for Tiam1, a guanine nucleotide exchange factor for Rac1, in glucose-stimulated insulin secretion in pancreatic beta-cells.
Tiam1, a Rac1-specific guanine nucleotide exchange factor, was expressed mainly in the cytosol of AT2 cells exposed to mechanical strain compared with membrane localization in static cells.
Title: Mechanical stretch decreases migration of alveolar epithelial cells through mechanisms involving Rac1 and Tiam1.
16k PRL inhibits cell migration by blocking the Ras-Tiam1-Rac1-Pak1 signaling pathway in endothelial cells
Title: 16-kDa prolactin inhibits endothelial cell migration by down-regulating the Ras-Tiam1-Rac1-Pak1 signaling pathway.
Ras activation of a Rac1 exchange factor, Tiam1, mediates neurotrophin-3-induced Schwann cell migration.
Title: Ras activation of a Rac1 exchange factor, Tiam1, mediates neurotrophin-3-induced Schwann cell migration.
PAR-6-PAR-3 complex mediates Cdc42-induced Rac activation by means of STEF/Tiam1
Title: PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH132792 (e-PCR)
- UniSTS:216075

TIAM1 (e-PCR)
- UniSTS:506184

Tiam1 (e-PCR), detects polymorphism
- UniSTS:259157

RH132417 (e-PCR)
- UniSTS:215700

RH141943 (e-PCR)
- UniSTS:223934

ha2436 (e-PCR)
- UniSTS:515547

D11Got22 (e-PCR)
- UniSTS:112368

AW532393 (e-PCR)
- UniSTS:261883

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ephrin receptor binding	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Rac protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in activation of GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in activation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in brain-derived neurotrophic factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle hypertrophy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ephrin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neuron projection extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of JUN kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Schwann cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in protein localization to membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dopaminergic neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of modification of postsynaptic actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of modification of postsynaptic actin cytoskeleton	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of non-canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to cocaine	IEP Inferred from Expression Pattern more info	PubMed
involved_in small GTPase-mediated signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within small GTPase-mediated signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axonal growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell contact zone	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
is_active_in extrinsic component of postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in kinocilium	ISO Inferred from Sequence Orthology more info
located_in main axon	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in pericentriolar material	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in somatodendritic compartment	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: rho guanine nucleotide exchange factor TIAM1

Names: T-cell lymphoma invasion and metastasis 1; T-lymphoma invasion and metastasis-inducing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100558.2 → NP_001094028.1 rho guanine nucleotide exchange factor TIAM1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/TrEMBL

A0A8I6AC12, A6JLB5, D3ZWV8

Related

ENSRNOP00000089482.1, ENSRNOT00000109567.3

Conserved Domains (6) summary

smart00325
Location:1043 → 1232

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:845 → 924

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:431 → 557

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1234 → 1405

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

pfam18385
Location:571 → 668

Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

cl28922
Location:765 → 831

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

42517527..42866280 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039088432.2 → XP_038944360.1 rho guanine nucleotide exchange factor TIAM1 isoform X2

UniProtKB/TrEMBL

A0A8I6AC12, A6JLB5, D3ZWV8

Conserved Domains (6) summary

smart00325
Location:1043 → 1232

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:845 → 924

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:431 → 557

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1234 → 1405

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

pfam18385
Location:571 → 668

Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

cl28922
Location:765 → 831

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_063270597.1 → XP_063126667.1 rho guanine nucleotide exchange factor TIAM1 isoform X2

UniProtKB/TrEMBL

A0A8I6AC12, A6JLB5
XM_039088430.2 → XP_038944358.1 rho guanine nucleotide exchange factor TIAM1 isoform X2

UniProtKB/TrEMBL

A0A8I6AC12, A6JLB5, D3ZWV8

Conserved Domains (6) summary

smart00325
Location:1043 → 1232

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:845 → 924

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:431 → 557

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1234 → 1405

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

pfam18385
Location:571 → 668

Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

cl28922
Location:765 → 831

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_039088434.2 → XP_038944362.1 rho guanine nucleotide exchange factor TIAM1 isoform X2

UniProtKB/TrEMBL

A0A8I6AC12, A6JLB5, D3ZWV8

Conserved Domains (6) summary

smart00325
Location:1043 → 1232

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:845 → 924

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:431 → 557

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1234 → 1405

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

pfam18385
Location:571 → 668

Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

cl28922
Location:765 → 831

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_039088433.2 → XP_038944361.1 rho guanine nucleotide exchange factor TIAM1 isoform X2

UniProtKB/TrEMBL

A0A8I6AC12, A6JLB5, D3ZWV8

Conserved Domains (6) summary

smart00325
Location:1043 → 1232

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:845 → 924

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:431 → 557

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1234 → 1405

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

pfam18385
Location:571 → 668

Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

cl28922
Location:765 → 831

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_063270598.1 → XP_063126668.1 rho guanine nucleotide exchange factor TIAM1 isoform X2

UniProtKB/TrEMBL

A0A8I6AC12, A6JLB5
XM_039088429.2 → XP_038944357.1 rho guanine nucleotide exchange factor TIAM1 isoform X1

UniProtKB/TrEMBL

D3ZWV8

Related

ENSRNOP00000103376.1, ENSRNOT00000169253.1

Conserved Domains (6) summary

smart00325
Location:1062 → 1251

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:864 → 943

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:450 → 576

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1253 → 1424

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

pfam18385
Location:590 → 687

Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

cl28922
Location:784 → 850

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_039088435.2 → XP_038944363.1 rho guanine nucleotide exchange factor TIAM1 isoform X3

UniProtKB/TrEMBL

A0A8I6G1W3

Related

ENSRNOP00000104585.1, ENSRNOT00000152103.1

Conserved Domains (2) summary

smart00325
Location:75 → 264

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd01255
Location:266 → 437

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain