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    Myom2 myomesin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306616, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Myom2provided by RGD
    Official Full Name
    myomesin 2provided by RGD
    Primary source
    RGD:631437
    See related
    EnsemblRapid:ENSRNOG00000011754 AllianceGenome:RGD:631437
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable kinase binding activity. Involved in extraocular skeletal muscle development. Located in M band. Orthologous to human MYOM2 (myomesin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 5309.4) and Muscle (RPKM 4093.1) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Myom2 in Genome Data Viewer
    Location:
    16q12.5
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (81222467..81295025, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (74520148..74592658, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (79587136..79672871, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097555 Neighboring gene ribosomal oxygenase 2, pseudogene 2 Neighboring gene uncharacterized LOC102551089 Neighboring gene uncharacterized LOC102551149 Neighboring gene kelch repeat and BTB domain containing 11 Neighboring gene uncharacterized LOC134482526 Neighboring gene Rho guanine nucleotide exchange factor 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. M-protein is down-regulated in cardiac hypertrophy driven by thyroid hormone in rats. Rozanski A, et al. Mol Endocrinol, 2013 Dec. PMID 24176915, Free PMC Article
    2. CaMKII regulates the proteins TPM1 and MYOM2 and promotes diacetylmorphine-induced abnormal cardiac rhythms. Ji M, et al. Sci Rep, 2023 Apr 10. PMID 37037889, Free PMC Article
    3. Postnatal suppression of myomesin, muscle creatine kinase and the M-line in rat extraocular muscle. Porter JD, et al. J Exp Biol, 2003 Sep. PMID 12878677
    4. The globular head domain of titin extends into the center of the sarcomeric M band. cDNA cloning, epitope mapping and immunoelectron microscopy of two titin-associated proteins. Vinkemeier U, et al. J Cell Sci, 1993 Sep. PMID 7505783
    5. Muscle-type creatine kinase interacts with central domains of the M-band proteins myomesin and M-protein. Hornemann T, et al. J Mol Biol, 2003 Sep 26. PMID 12972258

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CaMKII regulates the proteins TPM1 and MYOM2 and promotes diacetylmorphine-induced abnormal cardiac rhythms.
      Title: CaMKII regulates the proteins TPM1 and MYOM2 and promotes diacetylmorphine-induced abnormal cardiac rhythms.
    2. the M-protein expression is strongly and rapidly repressed by triiodothyronine in cardiomyocytes.
      Title: M-protein is down-regulated in cardiac hypertrophy driven by thyroid hormone in rats.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in extraocular skeletal muscle development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in sarcomere organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sarcomere organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in M band IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in M band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in M band ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    myomesin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001169141.1 → NP_001162612.1  myomesin-2

      See identical proteins and their annotated locations for NP_001162612.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A6IWD0, G3V7K1
      Conserved Domains (6) summary
      cd05891
      Location:1345 → 1436
      IgI_M-protein_C; C-terminal immunoglobulin (Ig)-like domain of M-protein; member of the I-set of Ig superfamily (IgSF) domains
      PHA02826
      Location:1238 → 1433
      PHA02826; IL-1 receptor-like protein; Provisional
      cd00063
      Location:383 → 475
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:1146 → 1200
      Ig; Immunoglobulin domain
      cd20951
      Location:154 → 247
      IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
      cl11960
      Location:290 → 372
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      81222467..81295025 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094595.2 → XP_038950523.2  myomesin-2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AC90
      Related
      ENSRNOP00000090643.2, ENSRNOT00000097431.2

    2. XM_063275476.1 → XP_063131546.1  myomesin-2 isoform X1

      UniProtKB/TrEMBL
      A6IWD0, G3V7K1

    3. XM_063275477.1 → XP_063131547.1  myomesin-2 isoform X1

      UniProtKB/TrEMBL
      A6IWD0, G3V7K1
      Related
      ENSRNOP00000108608.1, ENSRNOT00000144379.1

    4. XM_006253389.5 → XP_006253451.1  myomesin-2 isoform X1

      See identical proteins and their annotated locations for XP_006253451.1

      UniProtKB/TrEMBL
      A6IWD0, G3V7K1
      Related
      ENSRNOP00000110543.1, ENSRNOT00000136084.1
      Conserved Domains (6) summary
      cd05891
      Location:1345 → 1436
      IgI_M-protein_C; C-terminal immunoglobulin (Ig)-like domain of M-protein; member of the I-set of Ig superfamily (IgSF) domains
      PHA02826
      Location:1238 → 1433
      PHA02826; IL-1 receptor-like protein; Provisional
      cd00063
      Location:383 → 475
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:1146 → 1200
      Ig; Immunoglobulin domain
      cd20951
      Location:154 → 247
      IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains
      cl11960
      Location:290 → 372
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

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