Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyp2d4provided by RGD
Official Full Name: cytochrome P450, family 2, subfamily d, polypeptide 4provided by RGD
Primary source: RGD:620640
See related: EnsemblRapid:ENSRNOG00000032261 AllianceGenome:RGD:620640
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cyp2d6; Cyp2d18; Cyp2d22; Cyp2d4v1; Cyp2d4v2
Summary: Enables arachidonate monooxygenase activity and progesterone 21-hydroxylase activity. Involved in several processes, including carboxylic acid metabolic process; dopamine biosynthetic process; and response to toluene. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Biomarker of traumatic brain injury. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hepatitis; extrapyramidal and movement disease; head and neck squamous cell carcinoma; leukemia (multiple); and major depressive disorder. Orthologous to several human genes including CYP2D6 (cytochrome P450 family 2 subfamily D member 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 459.8), Kidney (RPKM 57.9) and 2 other tissues See more
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Genomic context

Location:: 7q34

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (115762662..115771832, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (113882584..113891754, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (123599264..123608436, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Effect of Maternal High-Fat or High-Carbohydrate Diet during Pregnancy and Lactation on Cytochrome P450 2D (CYP2D) in the Liver and Brain of Rat Offspring.
Title: The Effect of Maternal High-Fat or High-Carbohydrate Diet during Pregnancy and Lactation on Cytochrome P450 2D (CYP2D) in the Liver and Brain of Rat Offspring.
Metabolic activation of zolmitriptan mediated by CYP2D6.
Title: Metabolic activation of zolmitriptan mediated by CYP2D6.
Schizonepetin had significant induction effects on CYP3A1/2 and inhibition effects on CYP1A2, CYP2E1 or CYP2D6 as oriented from the pharmacokinetic profiles of the substrates.
Title: Effects of schizonepetin on activity and mRNA expression of cytochrome p450 enzymes in rats.
Inhibition of brain CYP2D6 results in a lower analgesia response following opiate administration in a pain measurement test.
Title: First demonstration that brain CYP2D-mediated opiate metabolic activation alters analgesia in vivo.
Panax notoginseng saponins had no significant effects on the activities of CYP2C9, CYP2D6, and CYP3A4, but it could induce the activity of CYP1A2 in rats in vivo.
Title: Effects of Panax notoginseng saponins on the activities of CYP1A2, CYP2C9, CYP2D6 and CYP3A4 in rats in vivo.
Decreased recruitment of hnRNP K protein to the mutated sequence causes the low expression of CYP2D2 mRNA in dark agouti rats.
Title: The importance of heterogeneous nuclear ribonucleoprotein K on cytochrome P450 2D2 gene regulation: its binding is reduced in Dark Agouti rats.
concluded that a novel transcriptional regulatory element NERE specifically regulates the expression of the CYP2D4
Title: A novel transcriptional element which regulates expression of the CYP2D4 gene by Oct-1 and YY-1 binding.
results support the idea that cytochrome p450 CYP2D4, not P450c21, works as steroid 21-hydroxylase in the brain
Title: Cytochrome P450 2D catalyze steroid 21-hydroxylation in the brain.

Submit: New GeneRIF Correction

General gene information

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Markers

D7Mit16 (e-PCR), detects polymorphism
- UniSTS:119397

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables anandamide 11,12 epoxidase activity	ISO Inferred from Sequence Orthology more info
enables anandamide 14,15 epoxidase activity	ISO Inferred from Sequence Orthology more info
enables anandamide 8,9 epoxidase activity	ISO Inferred from Sequence Orthology more info
enables arachidonate monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info
enables progesterone 21-hydroxylase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in C21-steroid hormone metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in alkaloid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in alkaloid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in arachidonate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in arachidonate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in coumarin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in dopamine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dopamine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in estrogen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in isoquinoline alkaloid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in monoterpenoid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of organofluorine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in oxidative demethylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oxidative demethylation	ISO Inferred from Sequence Orthology more info
involved_in response to toluene	IEP Inferred from Expression Pattern more info	PubMed
involved_in retinol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in serotonin biosynthetic process from tryptophan	IDA Inferred from Direct Assay more info	PubMed
involved_in steroid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic catabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytochrome P450 2D4

Names: CYPIID18; CYPIID4; Cytochrome P450, subfamily IID4; P450 2D-29/2D-35; P450-CMF3; P450-DB4; cytochrome P450 2D-29; cytochrome P450 2D-35; cytochrome P450 2d18; cytochrome P450, family 2, subfamily d, polypeptide 22; cytochrome P450, subfamily 2D, polypeptide 6; cytochrome P450, subfamily IID, polypeptide 6; cytochrome P450-CMF3; cytochrome P450-DB4; debrisoquine 4-hydroxylase

NP_612524.1

EC 1.14.14.1

XP_038934287.1

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138515.2 → NP_612524.1 cytochrome P450 2D4

See identical proteins and their annotated locations for NP_612524.1

Status: PROVISIONAL

Source sequence(s)

U48219

UniProtKB/Swiss-Prot

O35107, P13108, Q566D3, Q64680

UniProtKB/TrEMBL

A6HT70

Related

ENSRNOP00000011880.4, ENSRNOT00000011880.8

Conserved Domains (1) summary

pfam00067
Location:37 → 496

p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

115762662..115771832 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039078359.2 → XP_038934287.1 cytochrome P450 2D4 isoform X1

Conserved Domains (1) summary

cl41757
Location:68 → 290

cytochrome_P450; cytochrome P450 (CYP) superfamily