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    Mtmr7 myotubularin related protein 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306490, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mtmr7provided by RGD
    Official Full Name
    myotubularin related protein 7provided by RGD
    Primary source
    RGD:1306608
    See related
    EnsemblRapid:ENSRNOG00000011420 AllianceGenome:RGD:1306608
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable inositol bisphosphate phosphatase activity; phosphatidylinositol-3,5-bisphosphate phosphatase activity; and phosphatidylinositol-3-phosphate phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation. Predicted to be located in cytosol and membrane. Predicted to be active in cytoplasm. Orthologous to human MTMR7 (myotubularin related protein 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 210.5), Kidney (RPKM 48.2) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mtmr7 in Genome Data Viewer
    Location:
    16q12.1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (58344755..58435682)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (51641267..51732212)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (54765214..54856255)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene a disintegrin and metallopeptidase domain 25 Neighboring gene ADAM metallopeptidase domain 24 Neighboring gene VPS37A subunit of ESCRT-I Neighboring gene CCR4-NOT transcription complex, subunit 7 Neighboring gene zinc finger DHHC-type palmitoyltransferase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9. Mochizuki Y, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12890864, Free PMC Article
    2. Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions. Lorenzo O, et al. J Cell Sci, 2006 Jul 15. PMID 16787938
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables inositol bisphosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3-phosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidylinositol dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphatidylinositol dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    myotubularin-related protein 7
    NP_001100782.2
    XP_038950459.1
    XP_038950460.1
    XP_038950461.1
    XP_063131499.1
    XP_063131500.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107312.3 → NP_001100782.2  myotubularin-related protein 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A8I6AEZ2, A0A8I6GGY0
      Related
      ENSRNOP00000091098.1, ENSRNOT00000105685.2
      Conserved Domains (2) summary
      cd13344
      Location:1 → 103
      PH-GRAM_MTMR7; Myotubularian (MTM) related 7 protein (MTMR7) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd14583
      Location:132 → 433
      PTP-MTMR7; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      58344755..58435682
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275429.1 → XP_063131499.1  myotubularin-related protein 7 isoform X1

      Related
      ENSRNOP00000071921.2, ENSRNOT00000086899.3

    2. XM_063275430.1 → XP_063131500.1  myotubularin-related protein 7 isoform X2

    3. XM_039094531.2 → XP_038950459.1  myotubularin-related protein 7 isoform X3

      UniProtKB/TrEMBL
      A6JPV0
      Conserved Domains (1) summary
      cl28904
      Location:5 → 291
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    4. XM_039094532.2 → XP_038950460.1  myotubularin-related protein 7 isoform X4

      Conserved Domains (1) summary
      cl28904
      Location:1 → 212
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    5. XM_039094533.2 → XP_038950461.1  myotubularin-related protein 7 isoform X5

      Conserved Domains (1) summary
      cl28904
      Location:17 → 205
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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