Edem2 ER degradation enhancing alpha-mannosidase like protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Edem2provided by RGD
Official Full Name: ER degradation enhancing alpha-mannosidase like protein 2provided by RGD
Primary source: RGD:1303074
See related: EnsemblRapid:ENSRNOG00000019299 AllianceGenome:RGD:1303074
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1303074
Summary: Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in endoplasmic reticulum unfolded protein response; glycoprotein catabolic process; and positive regulation of retrograde protein transport, ER to cytosol. Predicted to be located in endoplasmic reticulum quality control compartment and membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human EDEM2 (ER degradation enhancing alpha-mannosidase like protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 150.3), Spleen (RPKM 127.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (164661741..164687559, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (144201604..144227423, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (151232741..151258559, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BF400733 (e-PCR)
- UniSTS:245029

RH130626 (e-PCR)
- UniSTS:213910

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
NOT enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	ISO Inferred from Sequence Orthology more info
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum mannose trimming	IEA Inferred from Electronic Annotation more info
involved_in mannoprotein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of retrograde protein transport, ER to cytosol	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum quality control compartment	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ER degradation-enhancing alpha-mannosidase-like protein 2

Names: ER degradation enhancer, mannosidase alpha-like 2; ER degradation-enhancing alpha-mannosidase-like 2; ER degradation-enhancing-mannosidase-like protein 2

NP_001004230.1

EC 3.2.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004230.1 → NP_001004230.1 ER degradation-enhancing alpha-mannosidase-like protein 2 precursor

Status: PROVISIONAL

Source sequence(s)

BC079029

UniProtKB/TrEMBL

A0A8I6AA03, A6KI53, F7FAW8, Q6AYI8

Related

ENSRNOP00000026120.4, ENSRNOT00000026120.7

Conserved Domains (1) summary

pfam01532
Location:42 → 480

Glyco_hydro_47; Glycosyl hydrolase family 47