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    Nop58 NOP58 ribonucleoprotein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60373, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nop58provided by RGD
    Official Full Name
    NOP58 ribonucleoproteinprovided by RGD
    Primary source
    RGD:620484
    See related
    EnsemblRapid:ENSRNOG00000016486 AllianceGenome:RGD:620484
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nol5; Nap65
    Summary
    Predicted to enable ATPase binding activity; TFIID-class transcription factor complex binding activity; and snoRNA binding activity. Predicted to be involved in ribosomal small subunit biogenesis and snoRNA localization. Predicted to be located in Cajal body; cytosol; and fibrillar center. Predicted to be part of box C/D methylation guide snoRNP complex; pre-snoRNP complex; and small-subunit processome. Orthologous to human NOP58 (NOP58 ribonucleoprotein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 223.9), Spleen (RPKM 216.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Nop58 in Genome Data Viewer
    Location:
    9q31
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (68614992..68638911)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (61120939..61144810)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (66495881..66520521)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene KIAA2012 homolog Neighboring gene small ubiquitin-like modifier 1 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene Set nuclear proto-oncogene, pseudogene 16 Neighboring gene small nucleolar RNA, C/D box 70B Neighboring gene small nucleolar RNA, C/D box 70 Neighboring gene small nucleolar RNA, C/D box 11B Neighboring gene uncharacterized LOC134480582 Neighboring gene small nucleolar RNA, C/D box 11 Neighboring gene bone morphogenetic protein receptor type 2 Neighboring gene large ribosomal subunit protein eL21-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC105440

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase binding  
    enables TFIID-class transcription factor complex binding  
    enables protein binding PubMed 
    enables snoRNA binding  
    enables snoRNA binding  
    enables snoRNA binding  
    Process Evidence Code Pubs
    involved_in biological_process  
    involved_in ribosomal small subunit biogenesis  
    involved_in ribosomal small subunit biogenesis  
    involved_in ribosome biogenesis  
    involved_in snoRNA localization  
    Component Evidence Code Pubs
    located_in Cajal body  
    part_of box C/D methylation guide snoRNP complex  
    part_of box C/D methylation guide snoRNP complex  
    part_of box C/D methylation guide snoRNP complex  
    located_in cytosol  
    located_in cytosol  
    located_in fibrillar center  
    located_in fibrillar center  
    located_in nucleolus  
    located_in nucleolus  
    located_in nucleoplasm  
    part_of pre-snoRNP complex  
    part_of small-subunit processome  
    part_of small-subunit processome  
    part_of small-subunit processome  
    part_of small-subunit processome  
    part_of sno(s)RNA-containing ribonucleoprotein complex  

    General protein information

    Preferred Names
    nucleolar protein 58
    Names
    NOP58 ribonucleoprotein homolog
    Nopp140 associated protein
    nopp140-associated protein of 65 kDa
    nucleolar protein 5
    nucleolar protein NOP58

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021754.2NP_068522.1  nucleolar protein 58

      See identical proteins and their annotated locations for NP_068522.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      O88525, Q9QZ86
      UniProtKB/TrEMBL
      A0A8I5ZV87, A6IPB2
      Related
      ENSRNOP00000022676.3, ENSRNOT00000022676.8
      Conserved Domains (2) summary
      pfam01798
      Location:169396
      Nop; snoRNA binding domain, fibrillarin
      pfam08156
      Location:266
      NOP5NT; NOP5NT (NUC127) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      68614992..68638911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267663.1XP_063123733.1  nucleolar protein 58 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZV87
    2. XM_063267664.1XP_063123734.1  nucleolar protein 58 isoform X2

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