Mapk12 mitogen-activated protein kinase 12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mapk12provided by RGD
Official Full Name: mitogen-activated protein kinase 12provided by RGD
Primary source: RGD:70975
See related: EnsemblRapid:ENSRNOG00000031233 AllianceGenome:RGD:70975
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sapk3
Summary: Enables ATP binding activity and MAP kinase activity. Involved in negative regulation of cell cycle and protein phosphorylation. Located in cytoplasm. Orthologous to human MAPK12 (mitogen-activated protein kinase 12). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 389.8), Lung (RPKM 98.4) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (122085647..122096307, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (120206005..120216711, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (130109214..130120918, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine agonist-resistant prolactinomas.
Title: The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine agonist-resistant prolactinomas.
These results demonstrated that Exenatide improved cardiac function, increased translocation of GLUTs, and suppressed translocation of FAT/CD36 after myocardial I/R injury. This protective effect was mediated, at least in part, through modulation of the cardiac p38gamma MAPK.
Title: Exenatide Regulates Substrate Preferences Through the p38γ MAPK Pathway After Ischaemia/Reperfusion Injury in a Rat Heart.
distinct pattern of ERK6 expression in mature skeletal muscle cells and a specific role for ERK6 in muscle development or muscle function
Title: ERK6 is expressed in a developmentally regulated manner in rodent skeletal muscle.
SAPK3 activity towards PDZ domain-containing substrates such as alpha1-Syntrophin is inhibited by outer membrane protein 25.
Title: Outer membrane protein 25-a mitochondrial anchor and inhibitor of stress-activated protein kinase-3.
SAPK3 phosphorylates mitochondrial protein Sab
Title: Phosphorylation of the mitochondrial protein Sab by stress-activated protein kinase 3.
Cardiac expression and subcellular localization
Title: Cardiac expression and subcellular localization of the p38 mitogen-activated protein kinase member, stress-activated protein kinase-3 (SAPK3).
SAPK3/p38gamma binds preferentially to the 3d PDZ domain of SAP90 & phosphorylates Thr287 & Ser290 in vitro, & Ser290 in cells in response to cellular stresses. Phosphorylation of SAP90 depends on the binding of SAPK3/p38gamma to the PDZ domain of SAP90.
Title: Stress- and mitogen-induced phosphorylation of the synapse-associated protein SAP90/PSD-95 by activation of SAPK3/p38gamma and ERK1/ERK2.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables JUN kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables MAP kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in myoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: mitogen-activated protein kinase 12

Names: ERK-6; MAP kinase 12; MAP kinase p38 gamma; MAPK 12; SAP kinase-3; extracellular signal-regulated kinase 6; mitogen-activated protein kinase p38 gamma; stress-activated protein kinase 3

NP_068514.1

EC 2.7.11.24

XP_038935761.1

EC 2.7.11.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021746.2 → NP_068514.1 mitogen-activated protein kinase 12

See identical proteins and their annotated locations for NP_068514.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

Q63538

UniProtKB/TrEMBL

A0A8I6A4Z8, A6K7K1

Related

ENSRNOP00000046455.3, ENSRNOT00000044376.6

Conserved Domains (1) summary

cd07880
Location:11 → 353

STKc_p38gamma; Catalytic domain of the Serine/Threonine Kinase, p38gamma Mitogen-Activated Protein Kinase (also called MAPK12)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

122085647..122096307 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039079833.2 → XP_038935761.1 mitogen-activated protein kinase 12 isoform X1

UniProtKB/TrEMBL

A6K7K2

Conserved Domains (1) summary

cl21453
Location:1 → 273

PKc_like; Protein Kinases, catalytic domain