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    Ndel1 nudE neurodevelopment protein 1-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170845, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ndel1provided by RGD
    Official Full Name
    nudE neurodevelopment protein 1-like 1provided by RGD
    Primary source
    RGD:621235
    See related
    EnsemblRapid:ENSRNOG00000004139 AllianceGenome:RGD:621235
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    EOPA; NUDE2; Nudel
    Summary
    Enables oligopeptidase activity. Involved in neuron projection development; positive regulation of axon extension; and positive regulation of axon regeneration. Acts upstream of or within nuclear membrane disassembly. Located in several cellular components, including central region of growth cone; centrosome; and nuclear envelope. Part of kinesin complex. Orthologous to human NDEL1 (nudE neurodevelopment protein 1 like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 224.5), Spleen (RPKM 156.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ndel1 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (54001435..54080909, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (53505628..53582025, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (55398919..55456654, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene microfibrillar-associated protein 1A like 1 Neighboring gene myosin heavy chain 10 Neighboring gene large ribosomal subunit protein eL30-like Neighboring gene ring finger protein 222 Neighboring gene peroxiredoxin 6, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-tubulin binding  
    enables alpha-tubulin binding  
    enables beta-tubulin binding  
    enables beta-tubulin binding  
    enables identical protein binding  
    enables identical protein binding  
    enables microtubule binding  
    enables microtubule binding  
    enables microtubule binding  
    enables oligopeptidase activity PubMed 
    enables protein binding PubMed 
    enables protein-containing complex binding PubMed 
    Items 1 - 25 of 55
    Process Evidence Code Pubs
    acts_upstream_of_or_within activation of GTPase activity  
    NOT involved_in canonical Wnt signaling pathway  
    involved_in cell migration  
    acts_upstream_of_or_within cell migration  
    involved_in central nervous system neuron axonogenesis  
    acts_upstream_of_or_within central nervous system neuron axonogenesis  
    involved_in centrosome localization  
    involved_in centrosome localization  
    acts_upstream_of_or_within centrosome localization  
    involved_in cerebral cortex radially oriented cell migration  
    involved_in cerebral cortex radially oriented cell migration  
    involved_in chromosome segregation  
    involved_in chromosome segregation  
    involved_in chromosome segregation  
    involved_in establishment of chromosome localization  
    involved_in establishment of mitotic spindle orientation  
    involved_in inner cell mass cell proliferation  
    acts_upstream_of_or_within inner cell mass cell proliferation  
    involved_in insulin receptor signaling pathway  
    involved_in insulin receptor signaling pathway  
    involved_in lysosome localization  
    involved_in lysosome localization  
    involved_in lysosome localization  
    acts_upstream_of_or_within microtubule cytoskeleton organization  
    involved_in microtubule nucleation  
    involved_in mitotic centrosome separation  
    involved_in mitotic centrosome separation  
    acts_upstream_of_or_within mitotic centrosome separation  
    involved_in nervous system development  
    involved_in neurofilament cytoskeleton organization  
    acts_upstream_of_or_within neurofilament cytoskeleton organization  
    acts_upstream_of_or_within neuron migration  
    involved_in neuron projection development PubMed 
    involved_in neuron projection extension  
    acts_upstream_of_or_within neuron projection extension  
    acts_upstream_of_or_within nuclear membrane disassembly PubMed 
    involved_in positive regulation of GTPase activity  
    involved_in positive regulation of axon extension PubMed 
    involved_in positive regulation of axon regeneration PubMed 
    involved_in positive regulation of ruffle assembly  
    involved_in positive regulation of ruffle assembly  
    involved_in positive regulation of ruffle assembly  
    involved_in radial glia-guided pyramidal neuron migration  
    acts_upstream_of_or_within radial glia-guided pyramidal neuron migration  
    involved_in regulation of intracellular protein transport  
    involved_in regulation of intracellular protein transport  
    involved_in regulation of neuron projection development  
    involved_in regulation of neuron projection development  
    involved_in regulation of neuron projection development PubMed 
    involved_in regulation of neuron projection development  
    involved_in retrograde axonal transport  
    acts_upstream_of_or_within retrograde axonal transport  
    involved_in vesicle transport along microtubule  
    involved_in vesicle transport along microtubule  
    acts_upstream_of_or_within vesicle transport along microtubule  
    Items 1 - 25 of 55
    Items 1 - 20 of 29
    Component Evidence Code Pubs
    located_in axon PubMed 
    located_in axon  
    located_in axon cytoplasm  
    located_in axon hillock  
    located_in axon hillock  
    located_in cell body PubMed 
    located_in cell leading edge  
    located_in cell leading edge  
    located_in central region of growth cone PubMed 
    is_active_in centrosome  
    located_in centrosome PubMed 
    located_in centrosome  
    located_in centrosome  
    located_in cytoplasm  
    part_of kinesin complex  
    part_of kinesin complex PubMed 
    is_active_in kinetochore  
    located_in kinetochore  
    located_in kinetochore  
    located_in microtubule  
    part_of microtubule associated complex  
    part_of microtubule associated complex  
    located_in microtubule organizing center  
    located_in neurofilament cytoskeleton  
    located_in neurofilament cytoskeleton  
    located_in nuclear envelope PubMed 
    located_in spindle  
    located_in synaptic vesicle  
    located_in synaptic vesicle  
    Items 1 - 20 of 29

    General protein information

    Preferred Names
    nuclear distribution protein nudE-like 1
    Names
    LIS1-interacting protein NUDEL
    LIS1-interacting protein NUDEL; endooligopeptidase A
    endooligopeptidase A
    nuclear distribution gene E-like homolog 1
    nudE nuclear distribution gene E homolog like 1
    protein Nudel

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133320.2NP_579854.1  nuclear distribution protein nudE-like 1

      See identical proteins and their annotated locations for NP_579854.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q6IRI4, Q78PB6
      UniProtKB/TrEMBL
      A0A8I6AEF7, A6HFL2
      Related
      ENSRNOP00000097143.2, ENSRNOT00000111866.2
      Conserved Domains (2) summary
      TIGR02168
      Location:24195
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam04880
      Location:135309
      NUDE_C; NUDE protein, C-terminal conserved region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      54001435..54080909 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017596976.3XP_017452465.1  nuclear distribution protein nudE-like 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A433, A0A8I6AR01
      Related
      ENSRNOP00000101084.1, ENSRNOT00000131309.1
    2. XM_039085116.2XP_038941044.1  nuclear distribution protein nudE-like 1 isoform X2

      UniProtKB/Swiss-Prot
      Q6IRI4, Q78PB6
      UniProtKB/TrEMBL
      A0A8I6AEF7, A6HFL2
      Conserved Domains (2) summary
      TIGR02168
      Location:24195
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam04880
      Location:135309
      NUDE_C; NUDE protein, C-terminal conserved region
    3. XM_063268360.1XP_063124430.1  nuclear distribution protein nudE-like 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A433
    4. XM_006246578.5XP_006246640.1  nuclear distribution protein nudE-like 1 isoform X3

      See identical proteins and their annotated locations for XP_006246640.1

      UniProtKB/TrEMBL
      A0A8I6A433
      Related
      ENSRNOP00000005574.6, ENSRNOT00000005574.9
      Conserved Domains (2) summary
      TIGR02168
      Location:24195
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam04880
      Location:135309
      NUDE_C; NUDE protein, C-terminal conserved region
    5. XM_063268359.1XP_063124429.1  nuclear distribution protein nudE-like 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A433
    6. XM_063268361.1XP_063124431.1  nuclear distribution protein nudE-like 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A433
    7. XM_039085117.2XP_038941045.1  nuclear distribution protein nudE-like 1 isoform X2

      UniProtKB/Swiss-Prot
      Q6IRI4, Q78PB6
      UniProtKB/TrEMBL
      A0A8I6AEF7, A6HFL2
      Conserved Domains (2) summary
      TIGR02168
      Location:24195
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam04880
      Location:135309
      NUDE_C; NUDE protein, C-terminal conserved region
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