Sfr1 SWI5-dependent homologous recombination repair protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sfr1provided by RGD
Official Full Name: SWI5-dependent homologous recombination repair protein 1provided by RGD
Primary source: RGD:1305481
See related: EnsemblRapid:ENSRNOG00000012641 AllianceGenome:RGD:1305481
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Meir5; LRRGT00030; RGD1305481
Summary: Predicted to enable nuclear receptor coactivator activity. Predicted to be involved in cellular response to estrogen stimulus; double-strand break repair via homologous recombination; and positive regulation of DNA-templated transcription. Predicted to be located in centrosome; nucleolus; and nucleoplasm. Predicted to be part of Swi5-Sfr1 complex. Orthologous to human SFR1 (SWI5 dependent homologous recombination repair protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 404.7), Thymus (RPKM 392.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q54

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (256560533..256564547)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (246619235..246623250)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (267505336..267509350)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables nuclear receptor coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor coactivator activity	IEA Inferred from Electronic Annotation more info
enables nuclear receptor coactivator activity	ISO Inferred from Sequence Orthology more info
enables nuclear receptor coactivator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular response to estrogen stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to estrogen stimulus	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via homologous recombination	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Swi5-Sfr1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Swi5-Sfr1 complex	IEA Inferred from Electronic Annotation more info
part_of Swi5-Sfr1 complex	ISO Inferred from Sequence Orthology more info
part_of Swi5-Sfr1 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: swi5-dependent recombination DNA repair protein 1 homolog

Names: MEI5 meiotic recombination protein homolog; MEI5 recombination repair protein homolog; SWI5-dependent recombination repair 1; liver regeneration-related protein LRRGT00030; meiosis protein 5 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001047856.2 → NP_001041321.2 swi5-dependent recombination DNA repair protein 1 homolog

Status: VALIDATED

Source sequence(s)

FM118556, JAXUCZ010000001

UniProtKB/TrEMBL

A0A0H2UHK0

Related

ENSRNOP00000016881.5, ENSRNOT00000016881.7

Conserved Domains (1) summary

pfam10376
Location:41 → 247

Mei5; Double-strand recombination repair protein