Rps19 ribosomal protein S19 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rps19provided by RGD
Official Full Name: ribosomal protein S19provided by RGD
Primary source: RGD:68440
See related: EnsemblRapid:ENSRNOG00000037897 AllianceGenome:RGD:68440
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rps19l2
Summary: Enables translation initiation factor binding activity. A structural constituent of ribosome. Predicted to be involved in several processes, including monocyte chemotaxis; regulation of respiratory burst involved in inflammatory response; and ribosomal small subunit biogenesis. Predicted to act upstream of or within Notch signaling pathway. Located in nucleolus. Part of cytosolic small ribosomal subunit. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia and Diamond-Blackfan anemia 1. Orthologous to human RPS19 (ribosomal protein S19). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 5366.2), Thymus (RPKM 4246.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (89608408..89614390)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (80480718..80486511)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (16802280..16807982, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RPS19 significantly compromised CXCR2-dependent MIF-triggered adhesion of monocytes to endothelial cells under flow conditions. We, therefore, propose that RPS19 acts as an extracellular negative regulator of MIF.
Title: Ribosomal protein S19 interacts with macrophage migration inhibitory factor and attenuates its pro-inflammatory function.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables fibroblast growth factor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of ribosome	IEA Inferred from Electronic Annotation more info
enables structural constituent of ribosome	ISO Inferred from Sequence Orthology more info
enables structural constituent of ribosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables translation initiation factor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of erythrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in maturation of SSU-rRNA	ISO Inferred from Sequence Orthology more info
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ISO Inferred from Sequence Orthology more info
involved_in monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of respiratory burst involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in nucleolus organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of respiratory burst involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in rRNA processing	ISO Inferred from Sequence Orthology more info
involved_in ribosomal small subunit assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal small subunit assembly	ISO Inferred from Sequence Orthology more info
involved_in ribosomal small subunit biogenesis	ISO Inferred from Sequence Orthology more info
involved_in ribosomal small subunit biogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosolic ribosome	ISO Inferred from Sequence Orthology more info
part_of cytosolic small ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic small ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
part_of cytosolic small ribosomal subunit	ISO Inferred from Sequence Orthology more info
part_of cytosolic small ribosomal subunit	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
located_in ribosome	IEA Inferred from Electronic Annotation more info
located_in ribosome	ISO Inferred from Sequence Orthology more info
part_of small ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
part_of small-subunit processome	ISO Inferred from Sequence Orthology more info
part_of small-subunit processome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: small ribosomal subunit protein eS19

Names: 40S ribosomal protein S19; ribosomal protein S19-like2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037346.2 → NP_001032423.1 small ribosomal subunit protein eS19

See identical proteins and their annotated locations for NP_001032423.1

Status: VALIDATED

Source sequence(s)

BC087641, CB720565

UniProtKB/Swiss-Prot

P17074

UniProtKB/TrEMBL

A6J917, F1LYF3

Related

ENSRNOP00000027246.6, ENSRNOT00000027246.7

Conserved Domains (1) summary

pfam01090
Location:5 → 141

Ribosomal_S19e; Ribosomal protein S19e

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

89608408..89614390

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063283883.1 → XP_063139953.1 small ribosomal subunit protein eS19 isoform X1

UniProtKB/TrEMBL

A0A8I6AFS6, A6J919
XM_063283889.1 → XP_063139959.1 small ribosomal subunit protein eS19 isoform X2

UniProtKB/TrEMBL

A0A8I6GLA3
XM_006228411.3 → XP_006228473.1 small ribosomal subunit protein eS19 isoform X3

See identical proteins and their annotated locations for XP_006228473.1

UniProtKB/Swiss-Prot

P17074

UniProtKB/TrEMBL

A6J917, F1LYF3

Conserved Domains (1) summary

pfam01090
Location:5 → 141

Ribosomal_S19e; Ribosomal protein S19e
XM_063283888.1 → XP_063139958.1 small ribosomal subunit protein eS19 isoform X1

UniProtKB/TrEMBL

A0A8I6AFS6, A6J919
XM_063283893.1 → XP_063139963.1 small ribosomal subunit protein eS19 isoform X3

UniProtKB/Swiss-Prot

P17074

UniProtKB/TrEMBL

A6J917, F1LYF3
XM_063283886.1 → XP_063139956.1 small ribosomal subunit protein eS19 isoform X1

UniProtKB/TrEMBL

A0A8I6AFS6, A6J919