Trim26 tripartite motif-containing 26 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trim26provided by RGD
Official Full Name: tripartite motif-containing 26provided by RGD
Primary source: RGD:1359126
See related: EnsemblRapid:ENSRNOG00000032930 AllianceGenome:RGD:1359126
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Znf173
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including defense response to symbiont; positive regulation of non-canonical NF-kappaB signal transduction; and protein K11-linked ubiquitination. Predicted to be active in cytoplasm and nucleus. Orthologous to human TRIM26 (tripartite motif containing 26). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 69.9), Spleen (RPKM 58.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (1711564..1736389, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (1708297..1731176, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (2201685..2224481, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH140419 (e-PCR)
- UniSTS:222494

RH132641 (e-PCR)
- UniSTS:215924

Trim26 (e-PCR), detects polymorphism
- UniSTS:144824

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral entry into host cell	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of viral entry into host cell	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of viral entry into host cell	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein K11-linked ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein K11-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in suppression of viral release by host	IEA Inferred from Electronic Annotation more info
involved_in suppression of viral release by host	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tripartite motif-containing protein 26

Names: tripartite motif protein 26; zinc finger protein 173

NP_001011665.1

EC 2.3.2.27

XP_008770914.1

EC 2.3.2.27

XP_038954563.1

EC 2.3.2.27

XP_038954564.1

EC 2.3.2.27

XP_038954565.1

EC 2.3.2.27

XP_038954566.1

EC 2.3.2.27

XP_063135156.1

EC 2.3.2.27

XP_063135157.1

EC 2.3.2.27

XP_063135158.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011665.4 → NP_001011665.1 tripartite motif-containing protein 26

See identical proteins and their annotated locations for NP_001011665.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/Swiss-Prot

P62603, Q6MFZ0

UniProtKB/TrEMBL

A0A0G2K415

Related

ENSRNOP00000001019.6, ENSRNOT00000001019.9

Conserved Domains (3) summary

smart00336
Location:97 → 138

BBOX; B-Box-type zinc finger

cl02614
Location:317 → 541

SPRY; SPRY domain

cl17238
Location:16 → 56

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

1711564..1736389 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039098637.2 → XP_038954565.1 tripartite motif-containing protein 26 isoform X2

UniProtKB/TrEMBL

A0A0G2K415

Conserved Domains (4) summary

cd16598
Location:38 → 82

RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins

cd19765
Location:125 → 163

Bbox2_TRIM10-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM10, TRIM15, TRIM26, TRIM31 and similar proteins

NF033927
Location:171 → 238

alph_xenorhab_B; alpha-xenorhabdolysin family binary toxin subunit B

cl02614
Location:339 → 563

SPRY; SPRY domain
XM_039098635.2 → XP_038954563.1 tripartite motif-containing protein 26 isoform X1

UniProtKB/TrEMBL

A0A0G2K415, A0A8I6A8Z6

Conserved Domains (4) summary

cd16598
Location:38 → 82

RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins

cd19765
Location:125 → 163

Bbox2_TRIM10-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM10, TRIM15, TRIM26, TRIM31 and similar proteins

NF033927
Location:171 → 238

alph_xenorhab_B; alpha-xenorhabdolysin family binary toxin subunit B

cl02614
Location:345 → 569

SPRY; SPRY domain
XM_039098638.2 → XP_038954566.1 tripartite motif-containing protein 26 isoform X3

UniProtKB/TrEMBL

A0A0G2K415, A6KR89

Conserved Domains (3) summary

cd16598
Location:13 → 57

RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins

cd19765
Location:100 → 138

Bbox2_TRIM10-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM10, TRIM15, TRIM26, TRIM31 and similar proteins

cl02614
Location:320 → 544

SPRY; SPRY domain
XM_063279087.1 → XP_063135157.1 tripartite motif-containing protein 26 isoform X4

UniProtKB/TrEMBL

A0A0G2K415
XM_008772692.4 → XP_008770914.1 tripartite motif-containing protein 26 isoform X3

See identical proteins and their annotated locations for XP_008770914.1

UniProtKB/TrEMBL

A0A0G2K415, A6KR89

Conserved Domains (3) summary

cd16598
Location:13 → 57

RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins

cd19765
Location:100 → 138

Bbox2_TRIM10-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM10, TRIM15, TRIM26, TRIM31 and similar proteins

cl02614
Location:320 → 544

SPRY; SPRY domain
XM_063279086.1 → XP_063135156.1 tripartite motif-containing protein 26 isoform X2

UniProtKB/TrEMBL

A0A0G2K415

Related

ENSRNOP00000098141.2, ENSRNOT00000120477.2
XM_039098636.2 → XP_038954564.1 tripartite motif-containing protein 26 isoform X1

UniProtKB/TrEMBL

A0A0G2K415, A0A8I6A8Z6

Related

ENSRNOP00000098153.2, ENSRNOT00000120493.2

Conserved Domains (4) summary

cd16598
Location:38 → 82

RING-HC_TRIM26_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 26 (TRIM26) and similar proteins

cd19765
Location:125 → 163

Bbox2_TRIM10-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM10, TRIM15, TRIM26, TRIM31 and similar proteins

NF033927
Location:171 → 238

alph_xenorhab_B; alpha-xenorhabdolysin family binary toxin subunit B

cl02614
Location:345 → 569

SPRY; SPRY domain
XM_063279088.1 → XP_063135158.1 tripartite motif-containing protein 26 isoform X4

UniProtKB/TrEMBL

A0A0G2K415