Nr1i3 nuclear receptor subfamily 1, group I, member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nr1i3provided by MGI
Official Full Name: nuclear receptor subfamily 1, group I, member 3provided by MGI
Primary source: MGI:MGI:1346307
See related: Ensembl:ENSMUSG00000005677 AllianceGenome:MGI:1346307
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CAR; MB67; Care2; ESTM32; CAR-beta
Summary: Enables DNA binding activity. Acts upstream of or within negative regulation of DNA-templated transcription. Located in cytosol and nucleus. Is expressed in several structures, including genitourinary system; gut; heart; liver; and thymus. Orthologous to human NR1I3 (nuclear receptor subfamily 1 group I member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in liver adult (RPKM 52.5), duodenum adult (RPKM 13.0) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H3; 1 79.21 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (171041503..171046414)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (171213934..171218845)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interaction with YAP underlies the species differences between humans and rodents in CAR-dependent hepatocyte proliferation.
Title: Interaction with YAP underlies the species differences between humans and rodents in CAR-dependent hepatocyte proliferation.
CAR Protects Females from Diet-Induced Steatosis and Associated Metabolic Disorders.
Title: CAR Protects Females from Diet-Induced Steatosis and Associated Metabolic Disorders.
Impact of Neonatal Activation of Nuclear Receptor CAR (Nr1i3) on Cyp2 Gene Expression in Adult Mouse Liver.
Title: Impact of Neonatal Activation of Nuclear Receptor CAR (Nr1i3) on Cyp2 Gene Expression in Adult Mouse Liver.
Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR).
Title: Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR).
CAR directs T cell adaptation to bile acids in the small intestine.
Title: CAR directs T cell adaptation to bile acids in the small intestine.
Activation of the Akt pathway by a constitutive androstane receptor agonist results in beta-catenin activation.
Title: Activation of the Akt pathway by a constitutive androstane receptor agonist results in β-catenin activation.
Nuclear receptor CAR-ERalpha signaling regulates the estrogen sulfotransferase gene in the liver.
Title: Nuclear receptor CAR-ERα signaling regulates the estrogen sulfotransferase gene in the liver.
CAR contributes an expansive role regulating energy metabolism, significantly impacting glucose and monocarboxylic acid utilization, fatty acid metabolism and lipid homeostasis, through receptor-mediated regulation of several genes in multiple associated pathways.
Title: Metabolomic Approaches Reveal the Role of CAR in Energy Metabolism.
RNA-Seq performed from livers of adult male C57BL/6 mice treated with PXR or CAR agonists identified differentially expressed lncRNAs-protein-coding genes (PCGs) pairs that displayed a high coregulatory pattern by PXR and CAR activation. Study was among the first to demonstrate that lncRNAs are regulated by PXR and CAR activation and that they may be important regulators of PCGs involved in xenobiotic metabolism.
Title: Regulation of Hepatic Long Noncoding RNAs by Pregnane X Receptor and Constitutive Androstane Receptor Agonists in Mouse Liver.
new findings in this report link an important role in CAR activation that is dependent upon oxidative stress.
Title: Isothiocyanates induce UGT1A1 in humanized UGT1 mice in a CAR dependent fashion that is highly dependent upon oxidative stress.

Submit: New GeneRIF Correction See all GeneRIFs (111)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI551208 (e-PCR)
- UniSTS:164138

Nr1i3 (e-PCR), detects polymorphism
- UniSTS:527460

AA209988 (e-PCR), detects polymorphism
- UniSTS:143018

Nr1i3 (e-PCR), detects polymorphism
- UniSTS:144066

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in osteoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: nuclear receptor subfamily 1 group I member 3

Names: constitutive androstane receptor; constitutively transactivates RAREs; orphan nuclear receptor MB67

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001243062.1 → NP_001229991.1 nuclear receptor subfamily 1 group I member 3 isoform 2

See identical proteins and their annotated locations for NP_001229991.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region which results in a frameshift, compared to variant 1. This results in a shorter and distinct C-terminus in isoform 2, compared to isoform 1.

Source sequence(s)

AI132241, AK133515

Consensus CDS

CCDS56654.1

UniProtKB/Swiss-Prot

O35627

Related

ENSMUSP00000074915.6, ENSMUST00000075469.12

Conserved Domains (2) summary

cd07156
Location:21 → 92

NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers

cl11397
Location:116 → 281

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001243063.1 → NP_001229992.1 nuclear receptor subfamily 1 group I member 3 isoform 3

See identical proteins and their annotated locations for NP_001229992.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an in-frame alternate splice site in the 3' coding, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.

Source sequence(s)

AI132241, AK133515, BC089541

Consensus CDS

CCDS56655.1

UniProtKB/TrEMBL

Q5FW96

Related

ENSMUSP00000106960.2, ENSMUST00000111328.8

Conserved Domains (2) summary

cd07156
Location:21 → 92

NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers

cl11397
Location:116 → 355

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_009803.5 → NP_033933.2 nuclear receptor subfamily 1 group I member 3 isoform 1

See identical proteins and their annotated locations for NP_033933.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC163497, AI132241, AK133515

Consensus CDS

CCDS15480.1

UniProtKB/Swiss-Prot

O35627, O35628, Q3V008

Related

ENSMUSP00000005820.5, ENSMUST00000005820.11

Conserved Domains (2) summary

cd07156
Location:21 → 92

NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers

cl11397
Location:116 → 356

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

171041503..171046414

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006496628.2 → XP_006496691.1 nuclear receptor subfamily 1 group I member 3 isoform X1

Conserved Domains (2) summary

cd07156
Location:21 → 92

NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers

cl11397
Location:116 → 318

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
XM_011238743.2 → XP_011237045.1 nuclear receptor subfamily 1 group I member 3 isoform X2

Conserved Domains (2) summary

cd07156
Location:21 → 92

NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers

cl11397
Location:116 → 281

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators