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    FAC1 AMP deaminase, putative / myoadenylate deaminase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818408, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FAC1
    Official Full Name
    AMP deaminase, putative / myoadenylate deaminase
    Primary source
    TAIR:AT2G38280
    Locus tag
    AT2G38280
    See related
    Araport:AT2G38280
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ADENOSINE 5'-MONOPHOSPHATE DEAMINASE; ATAMPD; EMBRYONIC FACTOR1; F16M14.21; F16M14_21
    Summary
    Encodes a protein with in vitro AMP deaminase activity that is involved in embryogenesis. Homozygous mutant embryos fail to develop past the zygote stage.
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    Genomic context

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    See FAC1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    20
    Sequence:
    Chromosome: 2; NC_003071.7 (16033292..16038972, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene CAX-interacting protein 2 Neighboring gene ammonium transporter 2 Neighboring gene myb-like HTH transcriptional regulator family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystallization and preliminary X-ray crystallographic analysis of adenosine 5'-monophosphate deaminase (AMPD) from Arabidopsis thaliana in complex with coformycin 5'-phosphate. Han BW, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2005 Aug 1. PMID 16511144, Free PMC Article
    2. EMBRYONIC FACTOR 1 encodes an AMP deaminase and is essential for the zygote to embryo transition in Arabidopsis. Xu J, et al. Plant J, 2005 Jun. PMID 15918887
    3. Membrane association, mechanism of action, and structure of Arabidopsis embryonic factor 1 (FAC1). Han BW, et al. J Biol Chem, 2006 May 26. PMID 16543243
    4. Multiple lines of evidence localize signaling, morphology, and lipid biosynthesis machinery to the mitochondrial outer membrane of Arabidopsis. Duncan O, et al. Plant Physiol, 2011 Nov. PMID 21896887, Free PMC Article
    5. Arabidopsis homolog of the yeast TREX-2 mRNA export complex: components and anchoring nucleoporin. Lu Q, et al. Plant J, 2010 Jan. PMID 19843313

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of the association between Arabidopsis FAC1 globular catalytic domain and intracellular membranes, with N-terminal transmembrane and disordered linker regions serving as the anchor and attachment to the globular catalytic domain
      Title: Membrane association, mechanism of action, and structure of Arabidopsis embryonic factor 1 (FAC1).
    2. preliminary X-ray crystallographic structure of adenosine 5'-monophosphate deaminase
      Title: Crystallization and preliminary X-ray crystallographic analysis of adenosine 5'-monophosphate deaminase (AMPD) from Arabidopsis thaliana in complex with coformycin 5'-phosphate.
    3. FAC1 is involved in early embryo development, most likely in providing sufficient ATP for embryo development to proceed beyond the zygote stage. [FAC1] [EMBRYONIC FACTOR 1]
      Title: EMBRYONIC FACTOR 1 encodes an AMP deaminase and is essential for the zygote to embryo transition in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_129384.3
    NM_179963.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables AMP deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP deaminase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein histidine kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in IMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    AMP deaminase, putative / myoadenylate deaminase
    NP_565886.1
    • EMBRYONIC FACTOR1 (FAC1); FUNCTIONS IN: AMP deaminase activity; INVOLVED IN: purine ribonucleoside monophosphate biosynthetic process, embryo development ending in seed dormancy; LOCATED IN: cytosol, nucleus, microsome; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Adenosine/AMP deaminase (InterPro:IPR001365), Adenosine/AMP deaminase active site (InterPro:IPR006650), AMP deaminase (InterPro:IPR006329); Has 1191 Blast hits to 1128 proteins in 362 species: Archae - 0; Bacteria - 226; Metazoa - 390; Fungi - 271; Plants - 78; Viruses - 0; Other Eukaryotes - 226 (source: NCBI BLink).
    NP_850294.1
    • EMBRYONIC FACTOR1 (FAC1); FUNCTIONS IN: AMP deaminase activity; INVOLVED IN: purine ribonucleoside monophosphate biosynthetic process, embryo development ending in seed dormancy; LOCATED IN: cytosol, nucleus, microsome; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Adenosine/AMP deaminase (InterPro:IPR001365), Adenosine/AMP deaminase active site (InterPro:IPR006650), AMP deaminase (InterPro:IPR006329); Has 1191 Blast hits to 1128 proteins in 362 species: Archae - 0; Bacteria - 226; Metazoa - 390; Fungi - 271; Plants - 78; Viruses - 0; Other Eukaryotes - 226 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      16033292..16038972 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129384.3 → NP_565886.1  AMP deaminase, putative / myoadenylate deaminase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565886.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DFX9, O80452, Q56XX1, Q93ZR9
      UniProtKB/TrEMBL
      A0A178VY66, A0A5S9X521
      Conserved Domains (1) summary
      PLN02768
      Location:1 → 839
      PLN02768; AMP deaminase

    2. NM_179963.3 → NP_850294.1  AMP deaminase, putative / myoadenylate deaminase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850294.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DFX9, O80452, Q56XX1, Q93ZR9
      UniProtKB/TrEMBL
      A0A178VY66, A0A5S9X521
      Conserved Domains (1) summary
      PLN02768
      Location:1 → 839
      PLN02768; AMP deaminase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O80452.2

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