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    SUF4 zinc finger (C2H2 type) family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839984, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SUF4
    Official Full Name
    zinc finger (C2H2 type) family protein
    Primary source
    TAIR:AT1G30970
    Locus tag
    AT1G30970
    See related
    Araport:AT1G30970
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F17F8.14; suppressor of FRIGIDA4
    Summary
    Encodes SUF4 (SUPPRESSOR of FRI 4), a putative zinc-finger-containing transcription factor that is required for delayed flowering in winter-annual Arabidopsis. suf4 mutations strongly suppress the late-flowering phenotype of FRI (FRIGIDA) mutants. suf4 mutants also show reduced H3K4 trimethylation at FLC (FLOWERING LOCUS C), a floral inhibitor. SUF4 may act to specifically recruit a putative histone H3 methyltransferase EFS (EARLY FLOWERING IN SHORT DAYS) and the PAF1-like complex to the FLC locus.
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    Genomic context

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    See SUF4 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    7
    Sequence:
    Chromosome: 1; NC_003070.9 (11040250..11043773, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene F-box family protein Neighboring gene GTP-binding family protein Neighboring gene ncRNA Neighboring gene Plant thionin family protein Neighboring gene Plant thionin family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SUPPRESSOR OF FRIGIDA (SUF4) Supports Gamete Fusion via Regulating Arabidopsis EC1 Gene Expression. Resentini F, et al. Plant Physiol, 2017 Jan. PMID 27920160, Free PMC Article
    2. SUPPRESSOR OF FRI 4 encodes a nuclear-localized protein that is required for delayed flowering in winter-annual Arabidopsis. Kim SY, et al. Development, 2006 Dec. PMID 17079264
    3. Arabidopsis SEC13B Interacts with Suppressor of Frigida 4 to Repress Flowering. Yang Y, et al. Int J Mol Sci, 2023 Dec 8. PMID 38139079, Free PMC Article
    4. Endopolyploidization and flowering time are antagonistically regulated by checkpoint component MAD1 and immunity modulator MOS1. Bao Z, et al. Nat Commun, 2014 Nov 28. PMID 25429892
    5. SUPPRESSOR OF FRIGIDA4, encoding a C2H2-Type zinc finger protein, represses flowering by transcriptional activation of Arabidopsis FLOWERING LOCUS C. Kim S, et al. Plant Cell, 2006 Nov. PMID 17138694, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis SEC13B Interacts with Suppressor of Frigida 4 to Repress Flowering.
      Title: Arabidopsis SEC13B Interacts with Suppressor of Frigida 4 to Repress Flowering.
    2. MOM1 contributes to the regulation of SUF4 and EC1 gene expression.
      Title: SUPPRESSOR OF FRIGIDA (SUF4) Supports Gamete Fusion via Regulating Arabidopsis EC1 Gene Expression.
    3. SUF4 forms a protein complex with FRI and FRL1 and functions as a transcriptional activator of FLC. [SUF4]
      Title: SUPPRESSOR OF FRIGIDA4, encoding a C2H2-Type zinc finger protein, represses flowering by transcriptional activation of Arabidopsis FLOWERING LOCUS C.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001084165.1
    NM_001332933.1
    NM_102836.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within epigenetic regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of flower development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger (C2H2 type) family protein
    NP_001077634.1
    • suppressor of FRIGIDA4 (SUF4); FUNCTIONS IN: DNA binding, protein homodimerization activity, protein heterodimerization activity, sequence-specific DNA binding transcription factor activity; INVOLVED IN: histone H3-K4 methylation, negative regulation of flower development, regulation of transcription; LOCATED IN: nucleus; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; Has 20927 Blast hits to 14395 proteins in 967 species: Archae - 31; Bacteria - 3069; Metazoa - 8441; Fungi - 3219; Plants - 3230; Viruses - 675; Other Eukaryotes - 2262 (source: NCBI BLink).
    NP_564369.1
    • suppressor of FRIGIDA4 (SUF4); CONTAINS InterPro DOMAIN/s: Zinc finger, C2H2-like (InterPro:IPR015880), Zinc finger, BED-type predicted (InterPro:IPR003656), Zinc finger, C2H2-type (InterPro:IPR007087); Has 21249 Blast hits to 14717 proteins in 989 species: Archae - 33; Bacteria - 3114; Metazoa - 8587; Fungi - 3278; Plants - 3255; Viruses - 686; Other Eukaryotes - 2296 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      11040250..11043773 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102836.3 → NP_564369.1  zinc finger (C2H2 type) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564369.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4I7U0, Q56YA6, Q8LE54, Q94BZ2, Q9C5G0, Q9FYI5
      UniProtKB/TrEMBL
      A0A178W1B6, A0A5S9WIV9
      Conserved Domains (2) summary
      PHA03247
      Location:122 → 312
      PHA03247; large tegument protein UL36; Provisional
      sd00019
      Location:14 → 33
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001332933.1 → NP_001322001.1  zinc finger (C2H2 type) family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W057, A0A1P8ASM0

    3. NM_001084165.1 → NP_001077634.1  zinc finger (C2H2 type) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077634.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W1B6, A0A5S9WIV9
      Conserved Domains (1) summary
      PHA03247
      Location:70 → 260
      PHA03247; large tegument protein UL36; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C5G0.1

    Gene LinkOut

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