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    SERK4 somatic embryogenesis receptor-like kinase 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 815862, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SERK4
    Official Full Name
    somatic embryogenesis receptor-like kinase 4
    Primary source
    TAIR:AT2G13790
    Locus tag
    AT2G13790
    See related
    Araport:AT2G13790
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AT2G13780; ATSERK4; BAK1-LIKE 1; BAK7; BKK1; BRI1- ASSOCIATED KINASE 7; BRI1- ASSOCIATED KINASE 7; F13J11.14; F13J11_14; somatic embryogenesis receptor-like kinase 4; SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE 4
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    Genomic context

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    See SERK4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    11
    Sequence:
    Chromosome: 2; NC_003071.7 (5741592..5746833)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene no-apical-meristem-associated carboxy-terminal domain protein Neighboring gene ncRNA Neighboring gene nuclease Neighboring gene somatic embryogenesis receptor-like kinase 5 Neighboring gene AGD2-like defense response protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. BAK7 displays unequal genetic redundancy with BAK1 in brassinosteroid signaling and early senescence in Arabidopsis. Jeong YJ, et al. Mol Cells, 2010 Mar. PMID 20108170
    2. Characterization of Somatic Embryogenesis Receptor-Like Kinase 4 as a Negative Regulator of Leaf Senescence in Arabidopsis. Li X, et al. Cells, 2019 Jan 14. PMID 30646631, Free PMC Article
    3. The Arabidopsis leucine-rich repeat receptor-like kinases BAK1/SERK3 and BKK1/SERK4 are required for innate immunity to hemibiotrophic and biotrophic pathogens. Roux M, et al. Plant Cell, 2011 Jun. PMID 21693696, Free PMC Article
    4. Loss of the common immune coreceptor BAK1 leads to NLR-dependent cell death. Wu Y, et al. Proc Natl Acad Sci U S A, 2020 Oct 27. PMID 33055218, Free PMC Article
    5. BAK1 and BKK1 regulate brassinosteroid-dependent growth and brassinosteroid-independent cell-death pathways. He K, et al. Curr Biol, 2007 Jul 3. PMID 17600708

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of the common immune coreceptor BAK1 leads to NLR-dependent cell death.
      Title: Loss of the common immune coreceptor BAK1 leads to NLR-dependent cell death.
    2. In this study, the SERK4 gene was found to be highly expressed in senescent leaves and to control leaf senescence in Arabidopsis.
      Title: Characterization of Somatic Embryogenesis Receptor-Like Kinase 4 as a Negative Regulator of Leaf Senescence in Arabidopsis.
    3. N-glycosylation and specific ERQC components are essential to activate bak1/serk4 cell death, and CRK4 is likely to be among client proteins of protein glycosylation involved in BAK1/SERK4-regulated cell death.
      Title: Specific control of Arabidopsis BAK1/SERK4-regulated cell death by protein glycosylation.
    4. Oligogalacturonides are sensed through multiple and partially redundant perception/transduction complexes, some targeted by AvrPto, but not necessarily comprising BAK1 and BKK1.
      Title: Immune responses induced by oligogalacturonides are differentially affected by AvrPto and loss of BAK1/BKK1 and PEPR1/PEPR2.
    5. SERK3 and SERK4 have diverged from the original SERK protein in both their extracellular and cytoplasmic domains.
      Title: On the Origin of SERKs: Bioinformatics Analysis of the Somatic Embryogenesis Receptor Kinases.
    6. serk1 bak1 bkk1 triple mutant exhibited drastically reduced expression of a number of genes critical to polar auxin transport, cell cycle, endodermis development and root meristem differentiatio
      Title: Somatic embryogenesis receptor kinases control root development mainly via brassinosteroid-independent actions in Arabidopsis thaliana.
    7. Data reveal that PAMP-triggered immunity (PTI) relies on ligand-induced recruitment of SERK3/4 and provides insight into the early PTI signaling events underlying this important layer of plant innate immunity.
      Title: The Arabidopsis leucine-rich repeat receptor-like kinases BAK1/SERK3 and BKK1/SERK4 are required for innate immunity to hemibiotrophic and biotrophic pathogens.
    8. BAK7 (SERK4) is a component of the brassinosteroid signaling pathway, with varying degrees of genetic redundancy with BAK1. It affects plant growth via BL-independent pathways in vivo.
      Title: BAK7 displays unequal genetic redundancy with BAK1 in brassinosteroid signaling and early senescence in Arabidopsis.
    9. study demonstrates that BAK1 and BKK1 (AtSERK4) have dual physiological roles: positively regulating a brassinosteroid (BR)-dependent plant growth pathway, and negatively regulating a BR-independent cell-death pathway
      Title: BAK1 and BKK1 regulate brassinosteroid-dependent growth and brassinosteroid-independent cell-death pathways.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_126955.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables receptor serine/threonine kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane receptor protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within brassinosteroid mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to hypoxia HEP PubMed 
    acts_upstream_of_or_within leaf senescence IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within plant-type hypersensitive response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in seedling development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    somatic embryogenesis receptor-like kinase 4
    NP_178999.2
    • somatic embryogenesis receptor-like kinase 4 (SERK4); FUNCTIONS IN: protein kinase activity, transmembrane receptor protein serine/threonine kinase activity; INVOLVED IN: in 6 processes; LOCATED IN: endomembrane system; EXPRESSED IN: rosette leaf, cauline leaf, fruit, root, flower; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: somatic embryogenesis receptor-like kinase 5 (TAIR:AT2G13800.1); Has 172318 Blast hits to 120437 proteins in 4454 species: Archae - 129; Bacteria - 14524; Metazoa - 44355; Fungi - 9158; Plants - 84468; Viruses - 411; Other Eukaryotes - 19273 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      5741592..5746833
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_126955.5 → NP_178999.2  somatic embryogenesis receptor-like kinase 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178999.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WW00, Q93ZV3, Q9SKG5
      UniProtKB/TrEMBL
      A0A5S9WXY1
      Conserved Domains (4) summary
      smart00221
      Location:295 → 568
      STYKc; Protein kinase; unclassified specificity
      sd00033
      Location:101 → 124
      LRR_RI; leucine-rich repeat [structural motif]
      pfam08263
      Location:30 → 72
      LRRNT_2; Leucine rich repeat N-terminal domain
      cl21453
      Location:300 → 571
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SKG5.2

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