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    KCS12 3-ketoacyl-CoA synthase 12 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817412, updated on 18-Sep-2024

    Summary

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    Official Symbol
    KCS12
    Official Full Name
    3-ketoacyl-CoA synthase 12
    Primary source
    TAIR:AT2G28630
    Locus tag
    AT2G28630
    See related
    Araport:AT2G28630
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    3-ketoacyl-CoA synthase 12; T8O18.8; T8O18_8
    Summary
    Encodes KCS12, a member of the 3-ketoacyl-CoA synthase family involved in the biosynthesis of VLCFA (very long chain fatty acids).
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    Genomic context

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    See KCS12 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    2
    Sequence:
    Chromosome: 2; NC_003071.7 (12274468..12277417, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene exocyst subunit exo70 family protein H5 Neighboring gene exocyst subunit exo70 family protein H8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fine-tuning the activities of β-KETOACYL-COA SYNTHASE 3 (KCS3) and KCS12 in Arabidopsis is essential for maintaining cuticle integrity. Huang H, et al. J Exp Bot, 2023 Nov 21. PMID 37615538
    2. Characterization of the closely related Arabidopsis thaliana β-ketoacyl-CoA synthases KCS3, KCS12 and KCS19. Zhang Z, et al. Plant J, 2024 Jul. PMID 38666591
    3. The VLCFA elongase gene family in Arabidopsis thaliana: phylogenetic analysis, 3D modelling and expression profiling. Joubès J, et al. Plant Mol Biol, 2008 Jul. PMID 18465198
    4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Characterization of the closely related Arabidopsis thaliana beta-ketoacyl-CoA synthases KCS3, KCS12 and KCS19.
      Title: Characterization of the closely related Arabidopsis thaliana β-ketoacyl-CoA synthases KCS3, KCS12 and KCS19.
    2. Fine-tuning the activities of beta-KETOACYL-COA SYNTHASE 3 (KCS3) and KCS12 in Arabidopsis is essential for maintaining cuticle integrity.
      Title: Fine-tuning the activities of β-KETOACYL-COA SYNTHASE 3 (KCS3) and KCS12 in Arabidopsis is essential for maintaining cuticle integrity.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_001336183.1
    NM_128424.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables fatty acid elongase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    3-ketoacyl-CoA synthase 12
    NP_001318305.1
    • 3-ketoacyl-CoA synthase 12 (KCS12); FUNCTIONS IN: transferase activity, transferring acyl groups other than amino-acyl groups, catalytic activity, acyltransferase activity; INVOLVED IN: response to osmotic stress; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thiolase-like (InterPro:IPR016039), Very-long-chain 3-ketoacyl-CoA synthase (InterPro:IPR012392), 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C-terminal (InterPro:IPR013747), FAE1/Type III polyketide synthase-like protein (InterPro:IPR013601), Thiolase-like, subgroup (InterPro:IPR016038); BEST Arabidopsis thaliana protein match is: 3-ketoacyl-CoA synthase 3 (TAIR:AT1G07720.1); Has 2195 Blast hits to 2173 proteins in 528 species: Archae - 0; Bacteria - 1011; Metazoa - 0; Fungi - 4; Plants - 1037; Viruses - 0; Other Eukaryotes - 143 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      12274468..12277417 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001336183.1 → NP_001318305.1  3-ketoacyl-CoA synthase 12 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LFQ0, Q9SIB2
      UniProtKB/TrEMBL
      A0A178VNX3, A0A5S9X243

    2. NM_128424.3 → NP_180431.1  3-ketoacyl-CoA synthase 12 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180431.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LFQ0, Q9SIB2
      UniProtKB/TrEMBL
      A0A178VNX3, A0A5S9X243
      Conserved Domains (2) summary
      pfam08392
      Location:25 → 305
      FAE1_CUT1_RppA; FAE1/Type III polyketide synthase-like protein
      cl21486
      Location:333 → 423
      Ketoacyl-synt_C; Beta-ketoacyl synthase, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SIB2.1

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