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    FU kinase family with ARM repeat domain-containing protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841446, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FU
    Official Full Name
    kinase family with ARM repeat domain-containing protein
    Primary source
    TAIR:AT1G50240
    Locus tag
    AT1G50240
    See related
    Araport:AT1G50240
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    FUSED
    Summary
    The FUSED (FU) gene belongs to Ser/Thr protein kinase family and has a key role in the hedgehog signaling pathway known to control cell proliferation and patterning in fruit flies and humans . Arabidopsis thaliana genome has a single Fu gene. Cytokinesis-defective mutants, which we named two-in-one (tio), result from mutations in Arabidopsis Fu. Phenotypic analysis of tio mutants reveals an essential role for TIO in conventional modes of cytokinesis in plant meristems and during male gametogenesis. TIO is tightly localized to the midline of the nascent phragmoplast and remains associated with the expanding phragmoplast ring. This gene was previously annotated as two gene models, AT1G50230.1 and AT1G50240.1, however the experimental evidence exists (Oh et al, Current Biology, 2005) showing that these two models are in fact single gene, named FUSED.
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    23
    Sequence:
    Chromosome: 1; NC_003070.9 (18606511..18614500)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene B3 domain protein Neighboring gene FTSH protease 1 Neighboring gene N-terminal-transmembrane-C2 domain type 5.1 Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene Phototropic-responsive NPH3 family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A divergent cellular role for the FUSED kinase family in the plant-specific cytokinetic phragmoplast. Oh SA, et al. Curr Biol, 2005 Dec 6. PMID 16332535
    2. A Genetic Screen for Mutations Affecting Cell Division in the Arabidopsis thaliana Embryo Identifies Seven Loci Required for Cytokinesis. Gillmor CS, et al. PLoS One, 2016. PMID 26745275, Free PMC Article
    3. Arabidopsis Fused kinase and the Kinesin-12 subfamily constitute a signalling module required for phragmoplast expansion. Oh SA, et al. Plant J, 2012 Oct. PMID 22709276
    4. Arabidopsis Fused kinase TWO-IN-ONE dominantly inhibits male meiotic cytokinesis. Oh SA, et al. Plant Reprod, 2014 Mar. PMID 24146312
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001333427.1
    NM_001333428.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables kinesin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cytokinesis by cell plate formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytokinesis by cell plate formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo sac cellularization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within male meiosis cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in phragmoplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kinase family with ARM repeat domain-containing protein
    NP_001319189.1
    • FUSED (FU); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Armadillo-like helical (InterPro:IPR011989), Armadillo (InterPro:IPR000225), 26S proteasome non-ATPase regulatory subunit 5 (InterPro:IPR019538), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Armadillo-type fold (InterPro:IPR016024); BEST Arabidopsis thaliana protein match is: serine/threonine protein kinase 2 (TAIR:AT3G08720.2); Has 138334 Blast hits to 135590 proteins in 4834 species: Archae - 164; Bacteria - 15793; Metazoa - 51363; Fungi - 13983; Plants - 33508; Viruses - 544; Other Eukaryotes - 22979 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      18606511..18614500
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001333427.1 → NP_001319189.1  kinase family with ARM repeat domain-containing protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q2QAV0, Q2QB51, Q9SX42
      UniProtKB/TrEMBL
      A0A178WC55, A0A5S9WQG3

    2. NM_001333428.1 → NP_001321239.1  kinase family with ARM repeat domain-containing protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q2QAV0, Q2QB51, Q9SX42
      UniProtKB/TrEMBL
      A0A178WC55, A0A5S9WQG3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2QAV0.1

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