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    Bid BH3 interacting domain death agonist [ Mus musculus (house mouse) ]

    Gene ID: 12122, updated on 9-Dec-2024

    Summary

    Official Symbol
    Bidprovided by MGI
    Official Full Name
    BH3 interacting domain death agonistprovided by MGI
    Primary source
    MGI:MGI:108093
    See related
    Ensembl:ENSMUSG00000004446 AllianceGenome:MGI:108093
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2700049M22Rik
    Summary
    Enables ubiquitin protein ligase binding activity. Involved in positive regulation of cellular component organization; protein-containing complex assembly; and release of cytochrome c from mitochondria. Acts upstream of or within several processes, including apoptotic signaling pathway; hepatocyte apoptotic process; and regulation of apoptotic process. Located in cytosol and mitochondrial membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and limb segment. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human BID (BH3 interacting domain death agonist). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 20.6), thymus adult (RPKM 10.6) and 26 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Bid in Genome Data Viewer
    Location:
    6 F1; 6 57.02 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (120870080..120894074, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (120893119..120917062, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6479 Neighboring gene predicted gene, 38889 Neighboring gene BCL2 like 13 Neighboring gene STARR-seq mESC enhancer starr_17194 Neighboring gene STARR-positive B cell enhancer ABC_E8126 Neighboring gene STARR-positive B cell enhancer ABC_E10407 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:120880485-120880722 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit G1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:120884294-120884494 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:120885601-120885784 Neighboring gene STARR-positive B cell enhancer ABC_E6480 Neighboring gene STARR-positive B cell enhancer ABC_E11335 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:120907410-120907630 Neighboring gene microtubule associated monooxygenase, calponin and LIM domain containing 3 Neighboring gene predicted gene, 43915 Neighboring gene STARR-positive B cell enhancer ABC_E6481 Neighboring gene predicted gene 4651

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic mitochondrial changes IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in establishment of protein localization to membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of protein localization to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hepatocyte apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in hepatocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hepatocyte apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within mitochondrial ATP synthesis coupled electron transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mitochondrial outer membrane permeabilization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of autophagy in response to ER overload ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of extrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of extrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of fibroblast apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of intrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of mitochondrial membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of release of cytochrome c from mitochondria IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of release of cytochrome c from mitochondria IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of release of cytochrome c from mitochondria ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within protein targeting to mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of mitochondrial membrane permeability involved in apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in release of cytochrome c from mitochondria IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within release of cytochrome c from mitochondria IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction in response to DNA damage TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in supramolecular fiber organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in supramolecular fiber organization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    BH3-interacting domain death agonist
    Names
    p22 BID

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007544.4NP_031570.2  BH3-interacting domain death agonist

      See identical proteins and their annotated locations for NP_031570.2

      Status: VALIDATED

      Source sequence(s)
      AK077657, AK161235
      Consensus CDS
      CCDS20486.1
      UniProtKB/Swiss-Prot
      P70444, Q99M39
      Related
      ENSMUSP00000004560.6, ENSMUST00000004560.12
      Conserved Domains (1) summary
      pfam06393
      Location:3192
      BID; BH3 interacting domain (BID)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      120870080..120894074 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505411.5XP_006505474.1  BH3-interacting domain death agonist isoform X1

      See identical proteins and their annotated locations for XP_006505474.1

      UniProtKB/Swiss-Prot
      P70444, Q99M39
      Conserved Domains (1) summary
      pfam06393
      Location:3192
      BID; BH3 interacting domain (BID)
    2. XM_006505410.4XP_006505473.1  BH3-interacting domain death agonist isoform X1

      See identical proteins and their annotated locations for XP_006505473.1

      UniProtKB/Swiss-Prot
      P70444, Q99M39
      Conserved Domains (1) summary
      pfam06393
      Location:3192
      BID; BH3 interacting domain (BID)
    3. XM_006505409.4XP_006505472.1  BH3-interacting domain death agonist isoform X1

      See identical proteins and their annotated locations for XP_006505472.1

      UniProtKB/Swiss-Prot
      P70444, Q99M39
      Conserved Domains (1) summary
      pfam06393
      Location:3192
      BID; BH3 interacting domain (BID)
    4. XM_036165767.1XP_036021660.1  BH3-interacting domain death agonist isoform X1

      UniProtKB/Swiss-Prot
      P70444, Q99M39
      Conserved Domains (1) summary
      pfam06393
      Location:3192
      BID; BH3 interacting domain (BID)