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    Toll-Interleukin-Resistance (TIR) domain family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841140, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Toll-Interleukin-Resistance (TIR) domain family protein
    Primary source
    TAIR:AT1G47370
    Locus tag
    AT1G47370
    See related
    Araport:AT1G47370
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T3F24.3; T3F24_3
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    7
    Sequence:
    Chromosome: 1; NC_003070.9 (17365898..17368703, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene F-box associated ubiquitination effector family protein Neighboring gene pseudo Neighboring gene Protein phosphatase 2C family protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TIR domains of plant immune receptors are 2',3'-cAMP/cGMP synthetases mediating cell death. Yu D, et al. Cell, 2022 Jun 23. PMID 35597242
    2. TIR-only protein RBA1 recognizes a pathogen effector to regulate cell death in Arabidopsis. Nishimura MT, et al. Proc Natl Acad Sci U S A, 2017 Mar 7. PMID 28137883, Free PMC Article
    3. A transcriptomics approach uncovers novel roles for poly(ADP-ribosyl)ation in the basal defense response in Arabidopsis thaliana. Briggs AG, et al. PLoS One, 2017. PMID 29284022, Free PMC Article
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TIR-only protein RBA1 (At1g47370) recognizes a pathogen effector to regulate cell death in Arabidopsis.
      Title: TIR-only protein RBA1 recognizes a pathogen effector to regulate cell death in Arabidopsis.
    Submit: New GeneRIF Correction

    General gene information

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    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in NAD catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in NADP catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in RNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cAMP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cGMP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response by callose deposition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in induction of programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of plant-type hypersensitive response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Toll-Interleukin-Resistance (TIR) domain family protein
    NP_175170.1
    • Toll-Interleukin-Resistance (TIR) domain family protein; FUNCTIONS IN: transmembrane receptor activity; INVOLVED IN: signal transduction, defense response, innate immune response; LOCATED IN: intrinsic to membrane; CONTAINS InterPro DOMAIN/s: Toll-Interleukin receptor (InterPro:IPR000157); BEST Arabidopsis thaliana protein match is: Toll-Interleukin-Resistance (TIR) domain family protein (TAIR:AT2G03300.1); Has 1597 Blast hits to 1536 proteins in 48 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 1597; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      17365898..17368703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_103631.1 → NP_175170.1  Toll-Interleukin-Resistance (TIR) domain family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175170.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4HT77, Q9FX07
      UniProtKB/TrEMBL
      A0A5S9WPM1
      Conserved Domains (1) summary
      pfam01582
      Location:16 → 171
      TIR; TIR domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4HT77.1

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