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    VLN2 villin 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818773, updated on 18-Sep-2024

    Summary

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    Official Symbol
    VLN2
    Official Full Name
    villin 2
    Primary source
    TAIR:AT2G41740
    Locus tag
    AT2G41740
    See related
    Araport:AT2G41740
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATVLN2; T11A7.16; T11A7_16; villin 2
    Summary
    Encodes a protein with high homology to animal villin.
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    Genomic context

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    See VLN2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    24
    Sequence:
    Chromosome: 2; NC_003071.7 (17410672..17417820, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene calcium-binding site protein Neighboring gene pseudo Neighboring gene DTW domain-containing protein Neighboring gene amino-terminal glutamine amidohydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis VILLIN2 and VILLIN3 act redundantly in sclerenchyma development via bundling of actin filaments. Bao C, et al. Plant J, 2012 Sep. PMID 22563899
    2. Arabidopsis VILLIN2 and VILLIN3 are required for the generation of thick actin filament bundles and for directional organ growth. van der Honing HS, et al. Plant Physiol, 2012 Mar. PMID 22209875, Free PMC Article
    3. Arabidopsis villins promote actin turnover at pollen tube tips and facilitate the construction of actin collars. Qu X, et al. Plant Cell, 2013 May. PMID 23715472, Free PMC Article
    4. Proteomic profiling of tandem affinity purified 14-3-3 protein complexes in Arabidopsis thaliana. Chang IF, et al. Proteomics, 2009 Jun. PMID 19452453, Free PMC Article
    5. Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism. Ito J, et al. J Proteome Res, 2011 Apr 1. PMID 21166475

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. VLN2 and VLN3 act redundantly in sclerenchyma development via bundling of actin filaments.
      Title: Arabidopsis VILLIN2 and VILLIN3 act redundantly in sclerenchyma development via bundling of actin filaments.
    2. Data indicate that the construction of actin collars was affected in vln2 vln5 double mutantpollen tubes.
      Title: Arabidopsis villins promote actin turnover at pollen tube tips and facilitate the construction of actin collars.
    3. VLN2 and VLN3 play a role in actin filament organization in Arabidopsis.
      Title: Arabidopsis VILLIN2 and VILLIN3 are required for the generation of thick actin filament bundles and for directional organ growth.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001336936.1
    NM_129738.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    villin 2
    NP_565958.1
    • villin 2 (VLN2); FUNCTIONS IN: actin binding, protein binding; INVOLVED IN: cytoskeleton organization; LOCATED IN: cellular_component unknown; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Gelsolin (InterPro:IPR007122), Villin headpiece (InterPro:IPR003128), Gelsolin domain (InterPro:IPR007123); BEST Arabidopsis thaliana protein match is: villin 3 (TAIR:AT3G57410.1); Has 3753 Blast hits to 2353 proteins in 268 species: Archae - 0; Bacteria - 52; Metazoa - 2426; Fungi - 285; Plants - 242; Viruses - 2; Other Eukaryotes - 746 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      17410672..17417820 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129738.5 → NP_565958.1  villin 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565958.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22946, O81644, Q0WV87, Q8RXZ3
      UniProtKB/TrEMBL
      A0A178VT62, A0A5S9X681
      Conserved Domains (8) summary
      cd11288
      Location:517 → 607
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:136 → 230
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:10 → 122
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:620 → 718
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:252 → 341
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:384 → 485
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      pfam02209
      Location:941 → 975
      VHP; Villin headpiece domain
      pfam13254
      Location:843 → 952
      DUF4045; Domain of unknown function (DUF4045)

    2. NM_001336936.1 → NP_001323674.1  villin 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22946, O81644, Q0WV87, Q8RXZ3
      UniProtKB/TrEMBL
      A0A178VT62, A0A5S9X681
      Conserved Domains (8) summary
      cd11288
      Location:517 → 607
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:136 → 230
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:10 → 122
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:620 → 718
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:252 → 341
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:384 → 485
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      pfam02209
      Location:941 → 975
      VHP; Villin headpiece domain
      pfam13254
      Location:843 → 952
      DUF4045; Domain of unknown function (DUF4045)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O81644.2

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