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    Dihydropterin pyrophosphokinase / Dihydropteroate synthase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843250, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Dihydropterin pyrophosphokinase / Dihydropteroate synthase
    Primary source
    TAIR:AT1G69190
    Locus tag
    AT1G69190
    See related
    Araport:AT1G69190
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F4N2.15
    Summary
    encodes a bifunctional cytosolic hydroxymethyldihydropterin pyrophosphokinase/ dihydropteroate synthase (HPPK/DHPS)that is involved in tetrahydrofolate biosynthesis and is responsive to oxidative stress.
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    3
    Sequence:
    Chromosome: 1; NC_003070.9 (26013012..26015018, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene suppressor Neighboring gene Squamosa promoter-binding protein-like (SBP domain) transcription factor family protein Neighboring gene Plant-specific transcription factor YABBY family protein Neighboring gene fructokinase-like protein Neighboring gene Uncharacterized protein family UPF0090

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cytosolic hydroxymethyldihydropterin pyrophosphokinase/dihydropteroate synthase from Arabidopsis thaliana: a specific role in early development and stress response. Storozhenko S, et al. J Biol Chem, 2007 Apr 6. PMID 17289662
    2. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dihydropteroate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within tetrahydrofolate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tetrahydrofolate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Dihydropterin pyrophosphokinase / Dihydropteroate synthase
    NP_001319354.1
    • Dihydropterin pyrophosphokinase / Dihydropteroate synthase; CONTAINS InterPro DOMAIN/s: Dihydropteroate synthase-like (InterPro:IPR011005), 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK (InterPro:IPR000550), Dihydropteroate synthase (InterPro:IPR006390), Pterin-binding (InterPro:IPR000489); BEST Arabidopsis thaliana protein match is: Dihydropterin pyrophosphokinase / Dihydropteroate synthase (TAIR:AT4G30000.1); Has 15022 Blast hits to 14981 proteins in 2537 species: Archae - 158; Bacteria - 9759; Metazoa - 8; Fungi - 169; Plants - 69; Viruses - 0; Other Eukaryotes - 4859 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      26013012..26015018 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001334402.1 → NP_001319354.1  Dihydropterin pyrophosphokinase / Dihydropteroate synthase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q1ENB6, Q9LE77
      UniProtKB/TrEMBL
      A0A654EMF2, A0A7G2E7J5
      Conserved Domains (2) summary
      cd00739
      Location:202 → 473
      DHPS; DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and ...
      pfam01288
      Location:15 → 141
      HPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1ENB6.1

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