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    CYP98A8 cytochrome P450, family 98, subfamily A, polypeptide 8 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843795, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CYP98A8
    Official Full Name
    cytochrome P450, family 98, subfamily A, polypeptide 8
    Primary source
    TAIR:AT1G74540
    Locus tag
    AT1G74540
    See related
    Araport:AT1G74540
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    cytochrome P450; F1M20.22; F1M20_22; family 98; polypeptide 8; subfamily A
    Summary
    Encodes a tricoumaroylspermidine / triferuloylspermidine meta-hydroxylase that participates in the formation of N<sup>1</sup>,N<sup>5</sup>-di(hydroxyferuloyol)- N<sup>10</sup>-sinapoyl spermidine, an important constituent of pollen. This gene appears to be expressed in young flower buds and inflorescence tips with notably high levels of expression in the tapetum and pollen.
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    Genomic context

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    See CYP98A8 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    1
    Sequence:
    Chromosome: 1; NC_003070.9 (28013180..28015049)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene HVA22 homologue A Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene cytochrome P450, family 98, subfamily A, polypeptide 9 Neighboring gene ncRNA Neighboring gene NAP1-related protein 1 Neighboring gene tRNA-Leu

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionary interplay between sister cytochrome P450 genes shapes plasticity in plant metabolism. Liu Z, et al. Nat Commun, 2016 Oct 7. PMID 27713409, Free PMC Article
    2. Evolution of a novel phenolic pathway for pollen development. Matsuno M, et al. Science, 2009 Sep 25. PMID 19779199
    3. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    NM_106114.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables dicoumaroyl monocaffeoyl spermidine meta-hydroxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables diferuloyl mono-(hydroxyferuloyl) spermidine meta-hydroxylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monocoumaroyl dicaffeoyl spermidine meta-hydroxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monoferuloyl di-(hydroxyferuloyl) spermidine meta-hydroxylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables tri-(feruloyl or hydroxyferuloyl) spermidine meta-hydroxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tricoumaroylspermidine meta-hydroxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables triferuloylspermidine meta-hydroxylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within spermidine hydroxycinnamate conjugate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within spermidine hydroxycinnamate conjugate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spermidine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450, family 98, subfamily A, polypeptide 8
    NP_177594.1
    • ''cytochrome P450, family 98, subfamily A, polypeptide 8'' (CYP98A8); FUNCTIONS IN: electron carrier activity, monooxygenase activity, iron ion binding, oxygen binding, heme binding; INVOLVED IN: oxidation reduction; EXPRESSED IN: petal, leaf whorl, sepal, flower; EXPRESSED DURING: petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group I (InterPro:IPR002401), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 98, subfamily A, polypeptide 9 (TAIR:AT1G74550.1); Has 31997 Blast hits to 31761 proteins in 1640 species: Archae - 46; Bacteria - 3325; Metazoa - 11653; Fungi - 6593; Plants - 9348; Viruses - 0; Other Eukaryotes - 1032 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      28013180..28015049
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106114.2 → NP_177594.1  cytochrome P450, family 98, subfamily A, polypeptide 8 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177594.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0MEG3, Q8L9A4, Q9CA61
      UniProtKB/TrEMBL
      A0A178WNC9, A0A5S9WUC0
      Conserved Domains (1) summary
      cd20656
      Location:58 → 480
      CYP98; cytochrome P450 family 98
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CA61.1

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