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    STOP1 C2H2 and C2HC zinc fingers superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 840339, updated on 18-Sep-2024

    Summary

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    Official Symbol
    STOP1
    Official Full Name
    C2H2 and C2HC zinc fingers superfamily protein
    Primary source
    TAIR:AT1G34370
    Locus tag
    AT1G34370
    See related
    Araport:AT1G34370
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtSTOP1; F7P12.7; F7P12_7; sensitive to proton rhizotoxicity 1
    Summary
    Encodes a putative nuclear Cys(2)His(2)-type zinc finger protein involved in H+ and Al3+ rhizotoxicity. In mutants exposed to aluminum stress, there is no induction of AtALMT1, an malate transporter known to be involved in the mediation of aluminum toxicity. Cell wall of the mutant is unstable in low pH medium (pH 4.5) in low Ca solution. This would mediate Ca-alleviation of low pH stress through pectin-Ca interaction.
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    Genomic context

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    See STOP1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    3
    Sequence:
    Chromosome: 1; NC_003070.9 (12550339..12552629)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene forkhead-associated (FHA) domain-containing protein Neighboring gene translation initiation factor 3 (IF-3) family protein Neighboring gene ncRNA Neighboring gene 5'-3' exonuclease family protein Neighboring gene auxin response factor 22

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Zinc finger protein STOP1 is critical for proton tolerance in Arabidopsis and coregulates a key gene in aluminum tolerance. Iuchi S, et al. Proc Natl Acad Sci U S A, 2007 Jun 5. PMID 17535918, Free PMC Article
    2. STOP1 regulatory system: Centered on multiple stress tolerance and cellular nutrient management. Koyama H, et al. Mol Plant, 2021 Oct 4. PMID 34438056
    3. Synergistic and antagonistic pleiotropy of STOP1 in stress tolerance. Sadhukhan A, et al. Trends Plant Sci, 2021 Oct. PMID 34253485
    4. STOP1 regulates multiple genes that protect arabidopsis from proton and aluminum toxicities. Sawaki Y, et al. Plant Physiol, 2009 May. PMID 19321711, Free PMC Article
    5. Arabidopsis transcription factor STOP1 directly activates expression of NOD26-LIKE MAJOR INTRINSIC PROTEIN5;1, and is involved in the regulation of tolerance to low-boron stress. Zhang C, et al. J Exp Bot, 2024 Apr 15. PMID 38307018

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis transcription factor STOP1 directly activates expression of NOD26-LIKE MAJOR INTRINSIC PROTEIN5;1, and is involved in the regulation of tolerance to low-boron stress.
      Title: Arabidopsis transcription factor STOP1 directly activates expression of NOD26-LIKE MAJOR INTRINSIC PROTEIN5;1, and is involved in the regulation of tolerance to low-boron stress.
    2. STOP1 Regulates LKS1 Transcription and Coordinates K(+)/NH4(+) Balance in Arabidopsis Response to Low-K(+) Stress.
      Title: STOP1 Regulates LKS1 Transcription and Coordinates K(+)/NH(4)(+) Balance in Arabidopsis Response to Low-K(+) Stress.
    3. Root responses to aluminium and iron stresses require the SIZ1 SUMO ligase to modulate the STOP1 transcription factor.
      Title: Root responses to aluminium and iron stresses require the SIZ1 SUMO ligase to modulate the STOP1 transcription factor.
    4. A transcription factor STOP1-centered pathway coordinates ammonium and phosphate acquisition in Arabidopsis.
      Title: A transcription factor STOP1-centered pathway coordinates ammonium and phosphate acquisition in Arabidopsis.
    5. STOP1 regulatory system: Centered on multiple stress tolerance and cellular nutrient management.
      Title: STOP1 regulatory system: Centered on multiple stress tolerance and cellular nutrient management.
    6. STOP1 activates NRT1.1-mediated nitrate uptake to create a favorable rhizospheric pH for plant adaptation to acidity.
      Title: STOP1 activates NRT1.1-mediated nitrate uptake to create a favorable rhizospheric pH for plant adaptation to acidity.
    7. Synergistic and antagonistic pleiotropy of STOP1 in stress tolerance.
      Title: Synergistic and antagonistic pleiotropy of STOP1 in stress tolerance.
    8. The SUMO E3 ligase SIZ1 partially regulates STOP1 SUMOylation and stability in Arabidopsis thaliana.
      Title: The SUMO E3 ligase SIZ1 partially regulates STOP1 SUMOylation and stability in Arabidopsis thaliana.
    9. Degradation of STOP1 mediated by the F-box proteins RAH1 and RAE1 balances aluminum resistance and plant growth in Arabidopsis thaliana.
      Title: Degradation of STOP1 mediated by the F-box proteins RAH1 and RAE1 balances aluminum resistance and plant growth in Arabidopsis thaliana.
    10. High affinity promoter binding of STOP1 is essential for early expression of novel aluminum-induced resistance genes GDH1 and GDH2 in Arabidopsis.
      Title: High affinity promoter binding of STOP1 is essential for early expression of novel aluminum-induced resistance genes GDH1 and GDH2 in Arabidopsis.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001333101.1
    NM_103160.5
    NM_179415.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to oxygen levels IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to salt stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cellular response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to acidic pH IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to acidic pH IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to acidic pH IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to aluminum ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to aluminum ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to aluminum ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to hydrogen peroxide IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    C2H2 and C2HC zinc fingers superfamily protein
    NP_001319144.1
    • sensitive to proton rhizotoxicity 1 (STOP1); CONTAINS InterPro DOMAIN/s: Zinc finger, C2H2-like (InterPro:IPR015880), Zinc finger, C2H2-type (InterPro:IPR007087), Zinc finger, double-stranded RNA binding (InterPro:IPR022755); BEST Arabidopsis thaliana protein match is: C2H2 and C2HC zinc fingers superfamily protein (TAIR:AT5G22890.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_174697.1
    • sensitive to proton rhizotoxicity 1 (STOP1); CONTAINS InterPro DOMAIN/s: Zinc finger, C2H2-like (InterPro:IPR015880), Zinc finger, C2H2-type (InterPro:IPR007087); BEST Arabidopsis thaliana protein match is: C2H2 and C2HC zinc fingers superfamily protein (TAIR:AT5G22890.1); Has 25295 Blast hits to 14002 proteins in 194 species: Archae - 0; Bacteria - 2; Metazoa - 23814; Fungi - 97; Plants - 697; Viruses - 0; Other Eukaryotes - 685 (source: NCBI BLink).
    NP_849746.1
    • sensitive to proton rhizotoxicity 1 (STOP1); CONTAINS InterPro DOMAIN/s: Zinc finger, C2H2-like (InterPro:IPR015880), Zinc finger, C2H2-type (InterPro:IPR007087); BEST Arabidopsis thaliana protein match is: C2H2 and C2HC zinc fingers superfamily protein (TAIR:AT5G22890.1); Has 25295 Blast hits to 14002 proteins in 194 species: Archae - 0; Bacteria - 2; Metazoa - 23814; Fungi - 97; Plants - 697; Viruses - 0; Other Eukaryotes - 685 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      12550339..12552629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_103160.5 → NP_174697.1  C2H2 and C2HC zinc fingers superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_174697.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A5A8C1, Q8LA79, Q9C8N5
      UniProtKB/TrEMBL
      A0A178WM47, A0A5S9WLR3
      Conserved Domains (3) summary
      sd00017
      Location:246 → 266
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:363 → 379
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:244 → 266
      zf-C2H2; Zinc finger, C2H2 type

    2. NM_001333101.1 → NP_001319144.1  C2H2 and C2HC zinc fingers superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0Z277, Q2V4J0

    3. NM_179415.1 → NP_849746.1  C2H2 and C2HC zinc fingers superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849746.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A5A8C1, Q8LA79, Q9C8N5
      UniProtKB/TrEMBL
      A0A178WM47, A0A5S9WLR3
      Conserved Domains (3) summary
      sd00017
      Location:246 → 266
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:363 → 379
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:244 → 266
      zf-C2H2; Zinc finger, C2H2 type
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C8N5.1

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