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    AGD2 ARF-GAP domain 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842378, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AGD2
    Official Full Name
    ARF-GAP domain 2
    Primary source
    TAIR:AT1G60860
    Locus tag
    AT1G60860
    See related
    Araport:AT1G60860
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARF-GAP domain 2; F23C21.2; F23C21_2
    Summary
    A member of ARF GAP domain (AGD), A thaliana has 15 members, grouped into four classes. AGD2 belongs to the class 1, together with AGD1, AGD3, and AGD4.
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    Genomic context

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    See AGD2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    19
    Sequence:
    Chromosome: 1; NC_003070.9 (22400857..22407824, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene tRNA-Gly Neighboring gene DNA-directed RNA polymerase family protein Neighboring gene maternal effect embryo arrest 9 Neighboring gene AGAMOUS-like-56

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Co-repressors AtSDR4L and DIG1 interact with transcription factor VAL2 and promote Arabidopsis seed-to-seedling transition. Lu B, et al. Plant Physiol, 2024 Jul 31. PMID 38652698, Free PMC Article
    2. SCARFACE encodes an ARF-GAP that is required for normal auxin efflux and vein patterning in Arabidopsis. Sieburth LE, et al. Plant Cell, 2006 Jun. PMID 16698946, Free PMC Article
    3. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_001333920.1
    NM_001333921.1
    NM_104767.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    ARF-GAP domain 2
    NP_176283.1
    • ARF-GAP domain 2 (AGD2); FUNCTIONS IN: ARF GTPase activator activity, zinc ion binding; INVOLVED IN: regulation of ARF GTPase activity; LOCATED IN: cytoplasm; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Arf GTPase activating protein (InterPro:IPR001164), Pleckstrin homology-type (InterPro:IPR011993), Ankyrin repeat-containing domain (InterPro:IPR020683), BAR (InterPro:IPR004148), Pleckstrin homology (InterPro:IPR001849), Ankyrin repeat (InterPro:IPR002110); BEST Arabidopsis thaliana protein match is: ARF-GAP domain 4 (TAIR:AT1G10870.1); Has 22643 Blast hits to 15173 proteins in 641 species: Archae - 75; Bacteria - 1664; Metazoa - 11505; Fungi - 2316; Plants - 1355; Viruses - 192; Other Eukaryotes - 5536 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      22400857..22407824 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104767.4 → NP_176283.1  ARF-GAP domain 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176283.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GWM9, Q9C6C3, Q9C964
      UniProtKB/TrEMBL
      A0A5S9WN58, A0A654EPX4
      Conserved Domains (7) summary
      cd07606
      Location:15 → 216
      BAR_SFC_plant; The Bin/Amphiphysin/Rvs (BAR) domain of the plant protein SCARFACE (SFC)
      smart00105
      Location:470 → 604
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:684 → 763
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13250
      Location:293 → 425
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      pfam00169
      Location:291 → 420
      PH; PH domain
      pfam13637
      Location:686 → 737
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:676 → 714
      ANK; ANK repeat [structural motif]

    2. NM_001333920.1 → NP_001322222.1  ARF-GAP domain 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ATE8, A0A5S9WN58, A0A654EPX4

    3. NM_001333921.1 → NP_001322221.1  ARF-GAP domain 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W1L4, A0A1P8ATB6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C6C3.1

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