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    ABA2 NAD(P)-binding Rossmann-fold superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841665, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ABA2
    Official Full Name
    NAD(P)-binding Rossmann-fold superfamily protein
    Primary source
    TAIR:AT1G52340
    Locus tag
    AT1G52340
    See related
    Araport:AT1G52340
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ABA DEFICIENT 2; ARABIDOPSIS THALIANA ABA DEFICIENT 2; ATABA2; ATSDR1; F19K6.3; F19K6_3; GIN1; GLUCOSE INSENSITIVE 1; IMPAIRED SUCROSE INDUCTION 4; ISI4; SALT RESISTANT 1; SDR1; SHORT-CHAIN DEHYDROGENASE REDUCTASE 1; SHORT-CHAIN DEHYDROGENASE/REDUCTASE 1; SIS4; SRE1; SUGAR-INSENSITIVE 4
    Summary
    Encodes a cytosolic short-chain dehydrogenase/reductase involved in the conversion of xanthoxin to ABA-aldehyde during ABA biosynthesis. Mutants are insensitive to sucrose and glucose.
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    Genomic context

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    See ABA2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    2
    Sequence:
    Chromosome: 1; NC_003070.9 (19489794..19491650, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene protein kinase family protein / C-type lectin domain-containing protein Neighboring gene Regulator of Vps4 activity in the MVB pathway protein Neighboring gene kinesin-like protein Neighboring gene Initiation factor eIF-4 gamma, MA3 Neighboring gene Late embryogenesis abundant (LEA) hydroxyproline-rich glycoprotein family Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ectopic expression of ABSCISIC ACID 2/GLUCOSE INSENSITIVE 1 in Arabidopsis promotes seed dormancy and stress tolerance. Lin PC, et al. Plant Physiol, 2007 Feb. PMID 17189333, Free PMC Article
    2. A unique short-chain dehydrogenase/reductase in Arabidopsis glucose signaling and abscisic acid biosynthesis and functions. Cheng WH, et al. Plant Cell, 2002 Nov. PMID 12417697, Free PMC Article
    3. The short-chain alcohol dehydrogenase ABA2 catalyzes the conversion of xanthoxin to abscisic aldehyde. González-Guzmán M, et al. Plant Cell, 2002 Aug. PMID 12172025, Free PMC Article
    4. Characterization of an Arabidopsis thaliana mutant that has a defect in ABA accumulation: ABA-dependent and ABA-independent accumulation of free amino acids during dehydration. Nambara E, et al. Plant Cell Physiol, 1998 Aug. PMID 9787459
    5. Biochemical characterization of the aba2 and aba3 mutants in Arabidopsis thaliana. Schwartz SH, et al. Plant Physiol, 1997 May. PMID 9159947, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A mechanism coordinating root elongation, endodermal differentiation, redox homeostasis and stress response.
      Title: A mechanism coordinating root elongation, endodermal differentiation, redox homeostasis and stress response.
    2. This study supports ABA2 as a late expression gene that might have a fine-tuning function in mediating abscisic acid biosynthesis through primary metabolic changes in response to stress.
      Title: Ectopic expression of ABSCISIC ACID 2/GLUCOSE INSENSITIVE 1 in Arabidopsis promotes seed dormancy and stress tolerance.
    3. involved in the stomatal response to reduced relative humidity
      Title: The identification of genes involved in the stomatal response to reduced atmospheric relative humidity.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_104113.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables alcohol dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables xanthoxin dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within abscisic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within proline biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of abscisic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to fructose IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sugar mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    NAD(P)-binding Rossmann-fold superfamily protein
    NP_175644.1
    • ABA DEFICIENT 2 (ABA2); CONTAINS InterPro DOMAIN/s: NAD(P)-binding domain (InterPro:IPR016040), Glucose/ribitol dehydrogenase (InterPro:IPR002347), Short-chain dehydrogenase/reductase SDR (InterPro:IPR002198); BEST Arabidopsis thaliana protein match is: NAD(P)-binding Rossmann-fold superfamily protein (TAIR:AT3G51680.1); Has 120353 Blast hits to 120130 proteins in 3578 species: Archae - 983; Bacteria - 78428; Metazoa - 5777; Fungi - 6239; Plants - 2770; Viruses - 5; Other Eukaryotes - 26151 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      19489794..19491650 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104113.5 → NP_175644.1  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175644.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C826
      UniProtKB/TrEMBL
      A0A178WN92, A0A5S9WL49
      Conserved Domains (1) summary
      PLN02253
      Location:3 → 285
      PLN02253; xanthoxin dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C826.1

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