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    MTM1 Myotubularin-like phosphatases II superfamily [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820220, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MTM1
    Official Full Name
    Myotubularin-like phosphatases II superfamily
    Primary source
    TAIR:AT3G10550
    Locus tag
    AT3G10550
    See related
    Araport:AT3G10550
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Arabidopsis thaliana myotubularin 1; AtMTM1; myotubularin 1
    Summary
    Has 3'-phosphatase activity against both phosphatidylinositol-3,5-bisphosphate (PtdIns3,5P2) and Phosphatidylinositol-3-phosphate (PtdIns3P). The in vitro activity was higher with PtdIns3,5P2 than with PtdIns3P.
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    Genomic context

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    See MTM1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    19
    Sequence:
    Chromosome: 3; NC_003074.8 (3292890..3298621, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene LOSS OF GIANT CELLS FROM ORGANS Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene 3-phosphoinositide-dependent protein kinase Neighboring gene Cytochrome P450 superfamily protein Neighboring gene cytochrome P450, family 77, subfamily A, polypeptide 6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Divergent functions of the myotubularin (MTM) homologs AtMTM1 and AtMTM2 in Arabidopsis thaliana: evolution of the plant MTM family. Ding Y, et al. Plant J, 2012 Jun. PMID 22324391
    2. The Arabidopsis chromatin modifier ATX1, the myotubularin-like AtMTM and the response to drought. Ding Y, et al. Plant Signal Behav, 2009 Nov. PMID 19901554, Free PMC Article
    3. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtMTM1 encodes a phosphoinositide 3'-phosphatase related to the animal myotubularins. AtMTM1 and the Arabidopsis chromatin modifier ATX1, co-regulate overlapping set of genes under drought conditions. [AtMTM1]
      Title: The Arabidopsis chromatin modifier ATX1, the myotubularin-like AtMTM and the response to drought.
    2. AtMTM1 is involved in elevating the cellular level of phosphatidylinositol 5-phosphate in response to dehydration stress.
      Title: Divergent functions of the myotubularin (MTM) homologs AtMTM1 and AtMTM2 in Arabidopsis thaliana: evolution of the plant MTM family.
    3. study reports that At3g10550, encodes a phosphoinositide 3'-phosphatase related to the animal myotubularins (AtMTM1); identifed an overlapping set of genes co-regulated by ATX1 and AtMTM under drought conditions
      Title: The Arabidopsis chromatin modifier ATX1, the myotubularin-like AtMTM and the response to drought.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_111891.7

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-3-phosphate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to water deprivation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Myotubularin-like phosphatases II superfamily
    NP_187666.5
    • Myotubularin-like phosphatases II superfamily; FUNCTIONS IN: phosphatidylinositol-3-phosphatase activity, phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity; INVOLVED IN: dephosphorylation; LOCATED IN: cellular_component unknown; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Protein-tyrosine phosphatase, active site (InterPro:IPR016130), Myotubularin phosphatase (InterPro:IPR017906), GRAM (InterPro:IPR004182), Myotubularin-related (InterPro:IPR010569); BEST Arabidopsis thaliana protein match is: Myotubularin-like phosphatases II superfamily (TAIR:AT5G04540.1); Has 1697 Blast hits to 1550 proteins in 179 species: Archae - 0; Bacteria - 0; Metazoa - 1273; Fungi - 128; Plants - 40; Viruses - 0; Other Eukaryotes - 256 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      3292890..3298621 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111891.7 → NP_187666.5  Myotubularin-like phosphatases II superfamily [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187666.5

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4J3T8, Q84W79, Q9CAF1, Q9LPP2
      UniProtKB/TrEMBL
      A0A178V871, A0A5S9XAT2, A0A7G2EJV0
      Conserved Domains (2) summary
      smart00568
      Location:52 → 111
      GRAM; domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins
      pfam06602
      Location:218 → 591
      Myotub-related; Myotubularin-like phosphatase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4J3T8.1

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