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    S6K2 serine/threonine protein kinase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820019, updated on 18-Sep-2024

    Summary

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    Official Symbol
    S6K2
    Official Full Name
    serine/threonine protein kinase 2
    Primary source
    TAIR:AT3G08720
    Locus tag
    AT3G08720
    See related
    Araport:AT3G08720
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Arabidopsis thaliana protein kinase 19; ARABIDOPSIS THALIANA PROTEIN KINASE 2; ARABIDOPSIS THALIANA SERINE/THREONINE PROTEIN KINASE 2; ATPK19; ATPK2; ATS6K2; serine/threonine protein kinase 2
    Summary
    Encodes a ribosomal-protein S6 kinase. Gene expression is induced by cold and salt (NaCl). Activation of AtS6k is regulated by 1-naphthylacetic acid and kinetin, at least in part, via a lipid kinase-dependent pathway. Phosphorylates specifically mammalian and plant S6 at 25 degrees C but not at 37 degrees C. Involved in translational up-regulation of ribosomal proteins.
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    Genomic context

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    See S6K2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Sequence:
    Chromosome: 3; NC_003074.8 (2648372..2651231, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme 12 Neighboring gene thioredoxin H-type 9 Neighboring gene protein-serine kinase 1 Neighboring gene elongation factor P (EF-P) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A heat-sensitive Arabidopsis thaliana kinase substitutes for human p70s6k function in vivo. Turck F, et al. Mol Cell Biol, 1998 Apr. PMID 9528776, Free PMC Article
    2. atpk1, a novel ribosomal protein kinase gene from Arabidopsis. I. Isolation, characterization, and expression. Zhang SH, et al. J Biol Chem, 1994 Jul 1. PMID 7912697
    3. Two genes that encode ribosomal-protein S6 kinase homologs are induced by cold or salinity stress in Arabidopsis thaliana. Mizoguchi T, et al. FEBS Lett, 1995 Jan 23. PMID 7828736
    4. Overexpression of the PP2A regulatory subunit Tap46 leads to enhanced plant growth through stimulation of the TOR signalling pathway. Ahn CS, et al. J Exp Bot, 2015 Feb. PMID 25399018, Free PMC Article
    5. A gene encoding a mitogen-activated protein kinase kinase kinase is induced simultaneously with genes for a mitogen-activated protein kinase and an S6 ribosomal protein kinase by touch, cold, and water stress in Arabidopsis thaliana. Mizoguchi T, et al. Proc Natl Acad Sci U S A, 1996 Jan 23. PMID 8570631, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001337766.1
    NM_001337767.1
    NM_111706.4
    NM_180212.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to hypoxia HEP PubMed 
    acts_upstream_of_or_within positive regulation of translation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to heat IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine protein kinase 2
    NP_187484.1
    • serine/threonine protein kinase 2 (S6K2); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), AGC-kinase, C-terminal (InterPro:IPR000961), Protein kinase, C-terminal (InterPro:IPR017892), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase-like domain (InterPro:IPR011009), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: protein-serine kinase 1 (TAIR:AT3G08730.1); Has 133901 Blast hits to 131707 proteins in 4554 species: Archae - 204; Bacteria - 15943; Metazoa - 48718; Fungi - 13429; Plants - 32816; Viruses - 561; Other Eukaryotes - 22230 (source: NCBI BLink).
    NP_850543.1
    • Arabidopsis thaliana protein kinase 19 (ATPK19); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), AGC-kinase, C-terminal (InterPro:IPR000961), Protein kinase-like domain (InterPro:IPR011009), Protein kinase, C-terminal (InterPro:IPR017892), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: protein-serine kinase 1 (TAIR:AT3G08730.1); Has 133901 Blast hits to 131707 proteins in 4554 species: Archae - 204; Bacteria - 15943; Metazoa - 48718; Fungi - 13429; Plants - 32816; Viruses - 561; Other Eukaryotes - 22230 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      2648372..2651231 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111706.4 → NP_187484.1  serine/threonine protein kinase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187484.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0V851, Q39030, Q949X5, Q9C5R1
      UniProtKB/TrEMBL
      A0A178VG08, A0A5S9XAI2
      Conserved Domains (3) summary
      smart00133
      Location:398 → 458
      S_TK_X; Extension to Ser/Thr-type protein kinases
      smart00220
      Location:140 → 395
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05123
      Location:146 → 395
      STKc_AGC; Catalytic domain of AGC family Serine/Threonine Kinases

    2. NM_180212.2 → NP_850543.1  serine/threonine protein kinase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850543.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0V851, Q39030, Q949X5, Q9C5R1
      UniProtKB/TrEMBL
      A0A178VG08, A0A5S9XAI2
      Conserved Domains (3) summary
      smart00133
      Location:398 → 458
      S_TK_X; Extension to Ser/Thr-type protein kinases
      smart00220
      Location:140 → 395
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05123
      Location:146 → 395
      STKc_AGC; Catalytic domain of AGC family Serine/Threonine Kinases

    3. NM_001337766.1 → NP_001327295.1  serine/threonine protein kinase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0V851, Q39030, Q949X5, Q9C5R1
      UniProtKB/TrEMBL
      A0A178VG08, A0A5S9XAI2

    4. NM_001337767.1 → NP_001327294.1  serine/threonine protein kinase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0V851, Q39030, Q949X5, Q9C5R1
      UniProtKB/TrEMBL
      A0A178VG08, A0A5S9XAI2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q39030.2

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