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    ATG2 autophagy 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821453, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ATG2
    Official Full Name
    autophagy 2
    Primary source
    TAIR:AT3G19190
    Locus tag
    AT3G19190
    See related
    Araport:AT3G19190
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATATG2; AUTOPHAGY 2; PEROXISOME UNUSUAL POSITIONING 1; PEUP1
    Summary
    Encodes autophagy-related 2 (ATG2).
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    Genomic context

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    See ATG2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    15
    Sequence:
    Chromosome: 3; NC_003074.8 (6639639..6648870)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene plastid division protein Neighboring gene AP2/B3-like transcriptional factor family protein Neighboring gene uncharacterized protein Neighboring gene DNA repair/recombination protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Autophagy-Related 2 Regulates Chlorophyll Degradation under Abiotic Stress Conditions in Arabidopsis. Jiang Z, et al. Int J Mol Sci, 2020 Jun 25. PMID 32630439, Free PMC Article
    2. ATG2, an autophagy-related protein, negatively affects powdery mildew resistance and mildew-induced cell death in Arabidopsis. Wang Y, et al. Plant J, 2011 Oct. PMID 21645148
    3. Arabidopsis AUTOPHAGY-RELATED2 is essential for ATG18a and ATG9 trafficking during autophagosome closure. Luo M, et al. Plant Physiol, 2023 Aug 31. PMID 37195145
    4. Autophagy-related (ATG) 11, ATG9 and the phosphatidylinositol 3-kinase control ATG2-mediated formation of autophagosomes in Arabidopsis. Kang S, et al. Plant Cell Rep, 2018 Apr. PMID 29350244
    5. Catalase and NO CATALASE ACTIVITY1 promote autophagy-dependent cell death in Arabidopsis. Hackenberg T, et al. Plant Cell, 2013 Nov. PMID 24285797, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis AUTOPHAGY-RELATED2 is essential for ATG18a and ATG9 trafficking during autophagosome closure.
      Title: Arabidopsis AUTOPHAGY-RELATED2 is essential for ATG18a and ATG9 trafficking during autophagosome closure.
    2. Autophagy-Related 2 Regulates Chlorophyll Degradation under Abiotic Stress Conditions in Arabidopsis.
      Title: Autophagy-Related 2 Regulates Chlorophyll Degradation under Abiotic Stress Conditions in Arabidopsis.
    3. After screening mutagenized lon2-2 seedlings for restored indole-3-butyric acid responsiveness, stabilization and processing of peroxisomal proteins, levels of several ATG proteins, and levels of the selective autophagy receptor NBR1/At4g24690, which accumulates when autophagy is impaired, were evaluated. The study recovered 21 alleles disrupting 6 ATG genes: ATG2, ATG3, ATG5, ATG7, ATG16, and ATG18a.
      Title: A facile forward-genetic screen for Arabidopsis autophagy mutants reveals twenty-one loss-of-function mutations disrupting six ATG genes.
    4. Data suggest that PI3K, ATG11 and ATG9 act upstream of ATG2 in Arabidopsis.
      Title: Autophagy-related (ATG) 11, ATG9 and the phosphatidylinositol 3-kinase control ATG2-mediated formation of autophagosomes in Arabidopsis.
    5. The atg2-2 mutant showed enhanced resistance to powdery mildew and dramatic mildew-induced cell death as well as early senescence phenotypes in the absence of pathogens. Defense-related genes were constitutively activated in atg2-2.
      Title: ATG2, an autophagy-related protein, negatively affects powdery mildew resistance and mildew-induced cell death in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_112806.3

    Gene Ontology Provided by TAIR

    Process Evidence Code Pubs
    involved_in autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in leaf senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    autophagy 2
    NP_188550.3
    • AUTOPHAGY 2 (ATG2); CONTAINS InterPro DOMAIN/s: autophagy-related, C-terminal (InterPro:IPR015412); Has 828 Blast hits to 713 proteins in 221 species: Archae - 0; Bacteria - 44; Metazoa - 384; Fungi - 228; Plants - 88; Viruses - 0; Other Eukaryotes - 84 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      6639639..6648870
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001338385.1 → NP_001327751.1  autophagy 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1I9LTA0, F4JB41, F8S296, Q9LJK9, Q9LJL0
      UniProtKB/TrEMBL
      A0A178V901

    2. NM_001338386.1 → NP_001327752.1  autophagy 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1I9LTA0, F4JB41, F8S296, Q9LJK9, Q9LJL0
      UniProtKB/TrEMBL
      A0A178V901

    3. NM_112806.3 → NP_188550.3  autophagy 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188550.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V901
      Conserved Domains (2) summary
      pfam09333
      Location:1725 → 1826
      ATG_C; Autophagy-related protein C terminal domain
      pfam12624
      Location:39 → 119
      Chorein_N; N-terminal region of Chorein or VPS13
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F8S296.1

    Gene LinkOut

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