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    SOG1 NAC (No Apical Meristem) domain transcriptional regulator superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839145, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SOG1
    Official Full Name
    NAC (No Apical Meristem) domain transcriptional regulator superfamily protein
    Primary source
    TAIR:AT1G25580
    Locus tag
    AT1G25580
    See related
    Araport:AT1G25580
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ANAC008; Arabidopsis NAC domain containing protein 8; F2J7.1; SUPPRESSOR OF GAMMA RADIATION 1
    Summary
    Encodes suppressor of gamma response 1 (SOG1), a putative transcription factor governing multiple responses to DNA damage.
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    Genomic context

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    See SOG1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Sequence:
    Chromosome: 1; NC_003070.9 (8996714..8999917, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene AP2/B3 transcription factor family protein Neighboring gene Di-glucose binding protein with Leucine-rich repeat domain-containing protein Neighboring gene coiled-coil protein (DUF572) Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis cryptochromes interact with SOG1 to promote the repair of DNA double-strand breaks. Chen L, et al. Biochem Biophys Res Commun, 2024 Sep 10. PMID 38865814
    2. In silico scanning of structural and functional deleterious nsSNPs in Arabidopsis thaliana's SOG1 protein, using molecular dynamic simulation approaches. Khan A, et al. J Biomol Struct Dyn, 2023. PMID 36734218
    3. A DNA-damage-induced cell cycle checkpoint in Arabidopsis. Preuss SB, et al. Genetics, 2003 May. PMID 12750343, Free PMC Article
    4. Suppressor of gamma response 1 (SOG1) encodes a putative transcription factor governing multiple responses to DNA damage. Yoshiyama K, et al. Proc Natl Acad Sci U S A, 2009 Aug 4. PMID 19549833, Free PMC Article
    5. SUPPRESSOR OF GAMMA RESPONSE 1 acts as a regulator coordinating crosstalk between DNA damage response and immune response in Arabidopsis thaliana. Yoshiyama KO, et al. Plant Mol Biol, 2020 Jun. PMID 32277429

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis cryptochromes interact with SOG1 to promote the repair of DNA double-strand breaks.
      Title: Arabidopsis cryptochromes interact with SOG1 to promote the repair of DNA double-strand breaks.
    2. SOG1 and BRCA1 Interdependently Regulate RAD54 Expression for Repairing Salinity-Induced DNA Double-Strand Breaks in Arabidopsis.
      Title: SOG1 and BRCA1 Interdependently Regulate RAD54 Expression for Repairing Salinity-Induced DNA Double-Strand Breaks in Arabidopsis.
    3. In silico scanning of structural and functional deleterious nsSNPs in Arabidopsis thaliana's SOG1 protein, using molecular dynamic simulation approaches.
      Title: In silico scanning of structural and functional deleterious nsSNPs in Arabidopsis thaliana's SOG1 protein, using molecular dynamic simulation approaches.
    4. Roles of MEM1 in safeguarding Arabidopsis genome against DNA damage, inhibiting ATM/SOG1-mediated DNA damage response, and antagonizing global DNA hypermethylation.
      Title: Roles of MEM1 in safeguarding Arabidopsis genome against DNA damage, inhibiting ATM/SOG1-mediated DNA damage response, and antagonizing global DNA hypermethylation.
    5. The Arabidopsis ATR-SOG1 signaling module regulates pleiotropic developmental adjustments in response to 3'-blocked DNA repair intermediates.
      Title: The Arabidopsis ATR-SOG1 signaling module regulates pleiotropic developmental adjustments in response to 3'-blocked DNA repair intermediates.
    6. both the N-terminal NAC domain and the C-terminal region of SOG1 have roles in regulating the stability of SOG1 protein under salinity stress in vitro
      Title: An insight into the folding and stability of Arabidopsis thaliana SOG1 transcription factor under salinity stress in vitro.
    7. These results suggest that SOG1 regulates crosstalk between DNA damage response and the immune response and that plants have evolved a sophisticated defense network to contend with environmental stress.
      Title: SUPPRESSOR OF GAMMA RESPONSE 1 acts as a regulator coordinating crosstalk between DNA damage response and immune response in Arabidopsis thaliana.
    8. SOG1, one of the newly identified components of DNA damage response in plant genome, appears to play central role in this signaling network. (Review)
      Title: An insight into the mechanism of DNA damage response in plants- role of SUPPRESSOR OF GAMMA RESPONSE 1: An overview.
    9. Together with the expected interaction of SOG1 with the promoter of NAC103, this study suggests that NAC103 is a putative SOG1-dependent transcriptional regulator of plant DNA damage response (DDR) genes, which are responsible for DDR phenotypes under genotoxic stress.
      Title: SOG1-dependent NAC103 modulates the DNA damage response as a transcriptional regulator in Arabidopsis.
    10. These results show that the extent of ser-gln phosphorylation in SOG1 regulates gene expression levels and determines the strength of DNA damage responses.
      Title: Increased Phosphorylation of Ser-Gln Sites on SUPPRESSOR OF GAMMA RESPONSE1 Strengthens the DNA Damage Response in Arabidopsis thaliana.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_102369.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to gamma radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    NAC (No Apical Meristem) domain transcriptional regulator superfamily protein
    NP_564238.2
    • SUPPRESSOR OF GAMMA RADIATION 1 (SOG1); FUNCTIONS IN: sequence-specific DNA binding transcription factor activity; INVOLVED IN: multicellular organismal development, response to gamma radiation, DNA damage checkpoint, regulation of meiosis; LOCATED IN: cellular_component unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: No apical meristem (NAM) protein (InterPro:IPR003441); BEST Arabidopsis thaliana protein match is: NAC domain containing protein 85 (TAIR:AT5G14490.1); Has 2166 Blast hits to 2160 proteins in 77 species: Archae - 0; Bacteria - 0; Metazoa - 22; Fungi - 5; Plants - 2134; Viruses - 0; Other Eukaryotes - 5 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      8996714..8999917 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102369.3 → NP_564238.2  NAC (No Apical Meristem) domain transcriptional regulator superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564238.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NQK2, Q9C610, Q9C6M7
      UniProtKB/TrEMBL
      A0A178WLI1, A0A385HDR1, A0A5S9VVT3
      Conserved Domains (1) summary
      pfam02365
      Location:59 → 192
      NAM; No apical meristem (NAM) protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NQK2.1

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