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    SR serine racemase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 826769, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SR
    Official Full Name
    serine racemase
    Primary source
    TAIR:AT4G11640
    Locus tag
    AT4G11640
    See related
    Araport:AT4G11640
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATSR; serine racemase; T5C23.70; T5C23_70
    Summary
    Serine racemase, which is a bifunctional PLP-dependent enzyme catalyzing racemization of serine and dehydration of serine to pyruvate in the same way as mammalian serine racemases. similar to mammalian serine racemases.
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    5
    Sequence:
    Chromosome: 4; NC_003075.7 (7021422..7023318)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene C2 calcium/lipid-binding plant phosphoribosyltransferase family protein Neighboring gene Ribosomal protein L19 family protein Neighboring gene miscRNA Neighboring gene ncRNA Neighboring gene osmotin 34

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Localization and expression of serine racemase in Arabidopsis thaliana. Sugimoto M, et al. Amino Acids, 2009 Mar. PMID 18546053
    2. Molecular and biochemical characterization of a serine racemase from Arabidopsis thaliana. Fujitani Y, et al. Phytochemistry, 2006 Apr. PMID 16483618
    3. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    NM_117233.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables D-serine ammonia-lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-serine ammonia-lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine racemase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine racemase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in D-serine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in L-serine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within serine family amino acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    serine racemase
    NP_192901.2
    • serine racemase (SR); CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent enzyme, beta subunit (InterPro:IPR001926), Serine/threonine dehydratase, pyridoxal-phosphate-binding site (InterPro:IPR000634); BEST Arabidopsis thaliana protein match is: L-O-methylthreonine resistant 1 (TAIR:AT3G10050.1); Has 19715 Blast hits to 19705 proteins in 2624 species: Archae - 539; Bacteria - 13612; Metazoa - 549; Fungi - 719; Plants - 186; Viruses - 2; Other Eukaryotes - 4108 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      7021422..7023318
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_117233.3 → NP_192901.2  serine racemase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_192901.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q2PGG3, Q9T0D1
      UniProtKB/TrEMBL
      A0A5S9XRD5, A0A654FNC7
      Conserved Domains (2) summary
      PLN02970
      Location:2 → 329
      PLN02970; serine racemase
      pfam00291
      Location:22 → 315
      PALP; Pyridoxal-phosphate dependent enzyme
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2PGG3.1

    Gene LinkOut

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