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    SKU5 Cupredoxin superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 826851, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SKU5
    Official Full Name
    Cupredoxin superfamily protein
    Primary source
    TAIR:AT4G12420
    Locus tag
    AT4G12420
    See related
    Araport:AT4G12420
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T1P17.10; T1P17_10
    Summary
    Encodes a protein of unknown function involved in directed root tip growth. It is a member of 19-member gene family and is distantly related structurally to the multiple-copper oxidases ascorbate oxidase and laccase, though it lacks the copper-binding domains. The protein is glycosylated and GPI-anchored. It is localized to the plasma membrane and the cell wall. The gene is expressed most strongly in expanding tissues.
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    Genomic context

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    See SKU5 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    10
    Sequence:
    Chromosome: 4; NC_003075.7 (7349187..7353135, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene tRNA-Asn Neighboring gene SAUR-like auxin-responsive protein family Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis SKU5 gene encodes an extracellular glycosyl phosphatidylinositol-anchored glycoprotein involved in directional root growth. Sedbrook JC, et al. Plant Cell, 2002 Jul. PMID 12119380, Free PMC Article
    2. Multi-copper oxidases SKU5 and SKS1 coordinate cell wall formation using apoplastic redox-based reactions in roots. Chen C, et al. Plant Physiol, 2023 Jul 3. PMID 37010107, Free PMC Article
    3. Proteomics of loosely bound cell wall proteins of Arabidopsis thaliana cell suspension cultures: a critical analysis. Borderies G, et al. Electrophoresis, 2003 Oct. PMID 14595688
    4. Identification of new intrinsic proteins in Arabidopsis plasma membrane proteome. Marmagne A, et al. Mol Cell Proteomics, 2004 Jul. PMID 15060130
    5. Hydroponic isotope labelling of entire plants (HILEP) for quantitative plant proteomics; an oxidative stress case study. Bindschedler LV, et al. Phytochemistry, 2008 Jul. PMID 18538804

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Multi-copper oxidases SKU5 and SKS1 coordinate cell wall formation using apoplastic redox-based reactions in roots.
      Title: Multi-copper oxidases SKU5 and SKS1 coordinate cell wall formation using apoplastic redox-based reactions in roots.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001203775.2
    NM_117312.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell tip growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apoplast HDA PubMed 
    located_in cytosol HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in plant-type cell wall HDA PubMed 
    located_in plant-type cell wall IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    Cupredoxin superfamily protein
    NP_001190704.1
    • SKU5; FUNCTIONS IN: oxidoreductase activity, copper ion binding; INVOLVED IN: cell tip growth; LOCATED IN: plasma membrane, anchored to membrane, plant-type cell wall; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Multicopper oxidase, type 3 (InterPro:IPR011707), Cupredoxin (InterPro:IPR008972), Multicopper oxidase, type 2 (InterPro:IPR011706), Multicopper oxidase, type 1 (InterPro:IPR001117); BEST Arabidopsis thaliana protein match is: SKU5 similar 2 (TAIR:AT5G51480.1).
    NP_192979.1
    • SKU5; FUNCTIONS IN: oxidoreductase activity, copper ion binding; INVOLVED IN: cell tip growth; LOCATED IN: in 7 components; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Multicopper oxidase, type 3 (InterPro:IPR011707), Cupredoxin (InterPro:IPR008972), Multicopper oxidase, type 2 (InterPro:IPR011706), Multicopper oxidase, type 1 (InterPro:IPR001117); BEST Arabidopsis thaliana protein match is: SKU5 similar 2 (TAIR:AT5G51480.1); Has 6156 Blast hits to 6132 proteins in 1213 species: Archae - 8; Bacteria - 2095; Metazoa - 284; Fungi - 2301; Plants - 1268; Viruses - 0; Other Eukaryotes - 200 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      7349187..7353135 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001203775.2 → NP_001190704.1  Cupredoxin superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190704.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WM56, Q8H7C9, Q9SU40
      UniProtKB/TrEMBL
      A0A178V188, A0A5S9XRW6, A0A654FNL1
      Conserved Domains (1) summary
      PLN00044
      Location:20 → 557
      PLN00044; multi-copper oxidase-related protein; Provisional

    2. NM_117312.4 → NP_192979.1  Cupredoxin superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_192979.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WM56, Q8H7C9, Q9SU40
      UniProtKB/TrEMBL
      A0A178V188, A0A5S9XRW6, A0A654FNL1
      Conserved Domains (1) summary
      PLN00044
      Location:20 → 557
      PLN00044; multi-copper oxidase-related protein; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SU40.1

    Gene LinkOut

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