AMT1;1 ammonium transporter 1;1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: AMT1;1
Official Full Name: ammonium transporter 1;1
Primary source: TAIR:AT4G13510
Locus tag: AT4G13510
See related: Araport:AT4G13510
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ammonium transporter 1;1; ARABIDOPSIS THALIANA AMMONIUM TRANSPORT 1; ATAMT1; ATAMT1;1; T6G15.60; T6G15_60
Summary: Encodes a plasma membrane localized ammonium transporter. Contains a cytosolic trans-activation domain essential for ammonium uptake.
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Genomic context

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See AMT1;1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 1

Sequence:: Chromosome: 4; NC_003075.7 (7858183..7860288)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphatidic acid regulates ammonium uptake by interacting with AMMONIUM TRANSPORTER 1;1 in Arabidopsis.
Title: Phosphatidic acid regulates ammonium uptake by interacting with AMMONIUM TRANSPORTER 1;1 in Arabidopsis.
Feedback inhibition of AMT1 NH4(+)-transporters mediated by CIPK15 kinase.
Title: Feedback inhibition of AMT1 NH(4)(+)-transporters mediated by CIPK15 kinase.
AMT1;1 and AMT1;3 form homo- and hetero-oligomers at the plasma membrane in plants.
Title: Allosteric regulation of transport activity by heterotrimerization of Arabidopsis ammonium transporter complexes in vivo.
AtNRT2.1 expression plays a key role in the regulation of AtAMT1.1 expression and in the NH(4)(+) ion influx, differentiating the nitrogen source, and particularly, the lack of it.
Title: Reciprocal regulation between AtNRT2.1 and AtAMT1.1 expression and the kinetics of NH(4)(+) and NO(3)(-) influxes.
The posttranscriptional regulation of AMT1 in transgenic N. tabacum plants is reported.
Title: Nitrogen-dependent posttranscriptional regulation of the ammonium transporter AtAMT1;1.
the soluble cytosolic carboxy terminus of AMT1 from Arabidopsis thaliana serves as an allosteric regulator essential for function; mutations in the C-terminal domain led to loss of transport activity
Title: A cytosolic trans-activation domain essential for ammonium uptake.
The results of this study suggest an additive contribution of AMT1;1 and AMT1;3 to the overall ammonium uptake capacity in Arabidopsis roots under nitrogen-deficiency conditions.
Title: Additive contribution of AMT1;1 and AMT1;3 to high-affinity ammonium uptake across the plasma membrane of nitrogen-deficient Arabidopsis roots.
participates in concentrative NH4+ acquisition in roots, in long-distance transport to the shoots, and in re-uptake of apoplastic NH4+ that derives from photorespiration in shoots
Title: Role of AMT1;1 in NH4+ acquisition in Arabidopsis thaliana.
Electrophysiological studies of Arabidopsis AtAMT1;1 expressed in oocytes revealed passive, Deltapsi-driven transport of NH(4)(+) through this protein.
Title: Mechanisms of ammonium transport, accumulation, and retention in ooyctes and yeast cells expressing Arabidopsis AtAMT1;1.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_117425.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ammonium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables ammonium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ammonium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within lateral root branching	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lateral root formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein polymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in response to flooding	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasmodesma	HDA more info	PubMed

General protein information

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Preferred Names: ammonium transporter 1;1

NP_193087.1

ammonium transporter 1;1 (AMT1;1); FUNCTIONS IN: ammonium transmembrane transporter activity; INVOLVED IN: ammonium transport, transport, protein polymerization, response to karrikin; LOCATED IN: nucleus, plasma membrane, membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Ammonium transporter (InterPro:IPR001905), Ammonium transporter, conserved site (InterPro:IPR018047); BEST Arabidopsis thaliana protein match is: ammonium transporter 1;3 (TAIR:AT3G24300.1); Has 11619 Blast hits to 11599 proteins in 2072 species: Archae - 224; Bacteria - 4688; Metazoa - 462; Fungi - 431; Plants - 505; Viruses - 0; Other Eukaryotes - 5309 (source: NCBI BLink).