EXT-like hydroxyproline-rich glycoprotein family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: EXT-like
Official Full Name: hydroxyproline-rich glycoprotein family protein
Primary source: TAIR:AT4G26750
Locus tag: AT4G26750
See related: Araport:AT4G26750
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: extensin-like; F10M23.90; F10M23_90; homolog of mammalian LYST-INTERACTING PROTEIN5; LIP5
Summary: Encodes a protein involved in mediating plant responses to pathogenesis. Loss of function mutations have increased susceptibility to bacterial pathogens and are defective in pathogen induced endocytosis and vesicle trafficking. LIP5 physically interacts with SKD1 and that interaction is required for its resistance phenotype. LIP5 is phosphorylated by MPK3 and MPK6, both of which are components of the disease resistance pathway.
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Genomic context

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See EXT-like in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 6

Sequence:: Chromosome: 4; NC_003075.7 (13475617..13478523, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ESCRT components ISTL1 andLIP5 are required for tapetal function and pollen viability.
Title: ESCRT components ISTL1 andLIP5 are required for tapetal function and pollen viability.
Results collectively indicate that the Multivesicular bodies pathway is positively regulated by pathogen/stress-responsive MPK3/6 through LIP5 phosphorylation. [LIP5]
Title: A Critical Role of Lyst-Interacting Protein5, a Positive Regulator of Multivesicular Body Biogenesis, in Plant Responses to Heat and Salt Stresses.
These results indicate that the MVB pathway is positively regulated by pathogen-responsive MPK3/6 through LIP5 phosphorylation and plays a critical role in plant immune system
Title: Arabidopsis LIP5, a positive regulator of multivesicular body biogenesis, is a critical target of pathogen-responsive MAPK cascade in plant basal defense.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

At-10C-213 (e-PCR)
- UniSTS:229365

NM_118809.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to other organism	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endosomal transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in late endosome to vacuole transport via multivesicular body sorting pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mucilage extrusion from seed coat	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pollen development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of vacuolar transport	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within vesicle-mediated transport	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with endosome	IPI Inferred from Physical Interaction more info	PubMed
located_in multivesicular body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: hydroxyproline-rich glycoprotein family protein

NP_194405.1

hydroxyproline-rich glycoprotein family protein; CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF605 (InterPro:IPR006745); BEST Arabidopsis thaliana protein match is: glucan synthase-like 11 (TAIR:AT3G59100.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

13475617..13478523 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_118809.5 → NP_194405.1 hydroxyproline-rich glycoprotein family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_194405.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9SZ15

UniProtKB/TrEMBL

A0A178UUB7, A0A5S9XW59, A0A654FT39

Conserved Domains (2) summary

PRK14086
Location:248 → 375

dnaA; chromosomal replication initiator protein DnaA

pfam04652
Location:16 → 142

Vta1; Vta1 like