ATMND1 Mnd1 family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ATMND1
Official Full Name: Mnd1 family protein
Primary source: TAIR:AT4G29170
Locus tag: AT4G29170
See related: Araport:AT4G29170
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F19B15.200; F19B15_200
Summary: A homolog of yeast, mouse and human mnd1delta protein. Null mutants exhibit normal vegetative and flower development; however, during prophase I, chromosomes become fragmented resulting in random distribution of the fragments between polyads. Both male and female meiosis are defective and strong accumulation of AtRAD51 was observed in the inflorescence nuclei of mutant plants. Similarly to its yeast and animal homologues, AtMnd1 might play a role in DSB repair during meiosis.
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Genomic context

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See ATMND1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 9

Sequence:: Chromosome: 4; NC_003075.7 (14382819..14385465)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A parallel orientation of the HOP2 and MND1 proteins in the HOP2-MND1 complex
Title: Comprehensive Cross-Linking Mass Spectrometry Reveals Parallel Orientation and Flexible Conformations of Plant HOP2-MND1.
AtMND1 is required for homologous pairing and is likely to play a role in the repair of DNA double strand breaks during meiosis in Arabidopsis.
Title: AtMND1 is required for homologous pairing during meiosis in Arabidopsis.
These results suggest that AtMnd1 is also required for double-strand breaks (DSB) repair in somatic cells.
Title: Atmnd1-delta1 is sensitive to gamma-irradiation and defective in meiotic DNA repair.
a key role in homologous synapsis and in DNA double-strand break repair during meiotic recombination
Title: The Arabidopsis thaliana MND1 homologue plays a key role in meiotic homologous pairing, synapsis and recombination.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001085000.2

Supported by ESTs:

NM_119061.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryo sac development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pollen development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reciprocal meiotic recombination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to ionizing radiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Mnd1 family protein

NP_001078469.1

ATMND1; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: double-strand break repair, embryo sac development, response to ionizing radiation, pollen development; LOCATED IN: cellular_component unknown; EXPRESSED IN: 12 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: Meiotic nuclear division protein 1 (InterPro:IPR005647); Has 323 Blast hits to 323 proteins in 161 species: Archae - 0; Bacteria - 2; Metazoa - 88; Fungi - 122; Plants - 42; Viruses - 0; Other Eukaryotes - 69 (source: NCBI BLink).

NP_194646.2

ATMND1; CONTAINS InterPro DOMAIN/s: Meiotic nuclear division protein 1 (InterPro:IPR005647); Has 334 Blast hits to 334 proteins in 171 species: Archae - 0; Bacteria - 2; Metazoa - 89; Fungi - 130; Plants - 42; Viruses - 0; Other Eukaryotes - 71 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

14382819..14385465

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001341959.1 → NP_001329788.1 Mnd1 family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B8S8
NM_001085000.2 → NP_001078469.1 Mnd1 family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001078469.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178V3X1, A0A654FTU4

Conserved Domains (1) summary

COG5124
Location:1 → 193

COG5124; Protein predicted to be involved in meiotic recombination [Cell division and chromosome partitioning / General function prediction only]
NM_119061.4 → NP_194646.2 Mnd1 family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_194646.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A8MS27, Q8GYD2, Q9SZE5

UniProtKB/TrEMBL

A0A178V4Z3, A0A5S9XWY5

Conserved Domains (1) summary

COG5124
Location:5 → 208

COG5124; Protein predicted to be involved in meiotic recombination [Cell division and chromosome partitioning / General function prediction only]