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    ENP Phototropic-responsive NPH3 family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829311, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ENP
    Official Full Name
    Phototropic-responsive NPH3 family protein
    Primary source
    TAIR:AT4G31820
    Locus tag
    AT4G31820
    See related
    Araport:AT4G31820
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ENHANCER OF PINOID; F11C18.20; F11C18_20; MAB4; MACCHI-BOU 4; NAKED PINS IN YUC MUTANTS 1; NPY1
    Summary
    A member of the NPY family genes (NPY1/AT4G31820, NPY2/AT2G14820, NPY3/AT5G67440, NPY4/AT2G23050, NPY5/AT4G37590). Encodes a protein with similarity to NHP3. Contains BTB/POZ domain. Promoter region has canonical auxin response element binding site and Wus binding site. Co-localizes to the late endosome with PID. Regulates cotyledon development through control of PIN1 polarity in concert with PID. Also involved in sepal and gynoecia development.
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    Genomic context

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    See ENP in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    4
    Sequence:
    Chromosome: 4; NC_003075.7 (15390519..15394626, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene WRKY DNA-binding protein 18 Neighboring gene WRKY family transcription factor Neighboring gene ATP-dependent caseinolytic (Clp) protease/crotonase family protein Neighboring gene uncharacterized protein Neighboring gene early nodulin-like protein 15

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The gene MACCHI-BOU 4/ENHANCER OF PINOID encodes a NPH3-like protein and reveals similarities between organogenesis and phototropism at the molecular level. Furutani M, et al. Development, 2007 Nov. PMID 17913786
    2. MAB4-induced auxin sink generates local auxin gradients in Arabidopsis organ formation. Furutani M, et al. Proc Natl Acad Sci U S A, 2014 Jan 21. PMID 24395791, Free PMC Article
    3. The gene ENHANCER OF PINOID controls cotyledon development in the Arabidopsis embryo. Treml BS, et al. Development, 2005 Sep. PMID 16107478
    4. NPY1, a BTB-NPH3-like protein, plays a critical role in auxin-regulated organogenesis in Arabidopsis. Cheng Y, et al. Proc Natl Acad Sci U S A, 2007 Nov 20. PMID 18000043, Free PMC Article
    5. Polar-localized NPH3-like proteins regulate polarity and endocytosis of PIN-FORMED auxin efflux carriers. Furutani M, et al. Development, 2011 May. PMID 21490067

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a novel gene, MAB4, which is involved in organogenesis in concert with PID has been reported. It encodes a NPH3-like protein and is identical to ENP. [MACCHI-BOU 4] [MAB4]
      Title: The gene MACCHI-BOU 4/ENHANCER OF PINOID encodes a NPH3-like protein and reveals similarities between organogenesis and phototropism at the molecular level.
    2. NPY1 works with the protein kinase PID, which is homologous to PHOT1, to regulate auxin-mediated plant development. [NPY1]
      Title: NPY1, a BTB-NPH3-like protein, plays a critical role in auxin-regulated organogenesis in Arabidopsis.
    3. Enhancer of Pinoid (ENP) protein specifically regulates cotyledon development through control of PIN1 polarity in concert with Pinoid.
      Title: The gene ENHANCER OF PINOID controls cotyledon development in the Arabidopsis embryo.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001342117.1
    NM_119332.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within apical protein localization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within basipetal auxin transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular response to auxin stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within cotyledon development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within flower development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within inflorescence development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within phyllome development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive gravitropism IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of flower development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization involved in auxin polar transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of auxin polar transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Phototropic-responsive NPH3 family protein
    NP_194910.2
    • ENHANCER OF PINOID (ENP); FUNCTIONS IN: signal transducer activity; INVOLVED IN: in 8 processes; LOCATED IN: late endosome, plasma membrane; EXPRESSED IN: 31 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: NPH3 (InterPro:IPR004249), BTB/POZ (InterPro:IPR013069), BTB/POZ fold (InterPro:IPR011333), BTB/POZ-like (InterPro:IPR000210); BEST Arabidopsis thaliana protein match is: Phototropic-responsive NPH3 family protein (TAIR:AT5G67440.1); Has 898 Blast hits to 870 proteins in 31 species: Archae - 0; Bacteria - 0; Metazoa - 7; Fungi - 2; Plants - 875; Viruses - 0; Other Eukaryotes - 14 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      15390519..15394626 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119332.4 → NP_194910.2  Phototropic-responsive NPH3 family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194910.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1P8B383, Q8H1D3, Q8RWY9, Q9SZ49
      UniProtKB/TrEMBL
      A0A5S9XY66, A0A654FUN1
      Conserved Domains (3) summary
      smart00225
      Location:30 → 117
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam03000
      Location:210 → 444
      NPH3; NPH3 family
      cl02518
      Location:29 → 112
      BTB; BTB/POZ domain

    2. NM_001342117.1 → NP_001327983.1  Phototropic-responsive NPH3 family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9XY66, A0A654FUN1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8H1D3.1

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