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    LEJ1 Cystathionine beta-synthase (CBS) family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829558, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LEJ1
    Official Full Name
    Cystathionine beta-synthase (CBS) family protein
    Primary source
    TAIR:AT4G34120
    Locus tag
    AT4G34120
    See related
    Araport:AT4G34120
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CBS domain containing protein 2; CBSX2; CDCP1; CYSTATHIONE [BETA]-SYNTHASE DOMAIN-CONTAINING PROTEIN 1; F28A23.120; F28A23_120; LOSS OF THE TIMING OF ET AND JA BIOSYNTHESIS 1
    Summary
    Encodes a single cystathionine beta-Synthase domain-containing protein. Modulates development by regulating the thioredoxin system.
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    Genomic context

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    See LEJ1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    8
    Sequence:
    Chromosome: 4; NC_003075.7 (16340907..16343118)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene poly(A) binding protein 2 Neighboring gene ncRNA Neighboring gene UDP-glucosyl transferase 73B3 Neighboring gene ncRNA Neighboring gene UDP-glucosyltransferase 73B2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CBSX2 is required for the efficient oxidation of chloroplast redox-regulated enzymes in darkness. Li Y, et al. Plant Direct, 2023 Nov. PMID 38028645, Free PMC Article
    2. A cystathionine-β-synthase domain-containing protein, CBSX2, regulates endothecial secondary cell wall thickening in anther development. Jung KW, et al. Plant Cell Physiol, 2013 Feb. PMID 23220733
    3. Crystal structure of the single cystathionine β-synthase domain-containing protein CBSX1 from Arabidopsis thaliana. Jeong BC, et al. Biochem Biophys Res Commun, 2013 Jan 4. PMID 23159611
    4. Single cystathionine β-synthase domain-containing proteins modulate development by regulating the thioredoxin system in Arabidopsis. Yoo KS, et al. Plant Cell, 2011 Oct. PMID 22021414, Free PMC Article
    5. Quantitative proteomics of a chloroplast SRP54 sorting mutant and its genetic interactions with CLPC1 in Arabidopsis. Rutschow H, et al. Plant Physiol, 2008 Sep. PMID 18633119, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ectopic expression of CBSX2 leads to partial male sterility due to defective anther dehiscence.
      Title: A cystathionine-β-synthase domain-containing protein, CBSX2, regulates endothecial secondary cell wall thickening in anther development.
    2. this study reports crystal structures of full-length CBSX1 and the internal loop deleted (Deltaloop) form at resolutions of 2.4 and 2.2A, respectively.
      Title: Crystal structure of the single cystathionine β-synthase domain-containing protein CBSX1 from Arabidopsis thaliana.
    3. Two CBS domain-containing proteins, CBSX1 and CBSX2, are localized to the chloroplast, where they activate all four thioredoxins in the ferredoxin-thioredoxin system in Arabidopsis thaliana.
      Title: Single cystathionine β-synthase domain-containing proteins modulate development by regulating the thioredoxin system in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_119573.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables enzyme regulator activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell redox homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in detection of redox state IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    Cystathionine beta-synthase (CBS) family protein
    NP_567952.1
    • LOSS OF THE TIMING OF ET AND JA BIOSYNTHESIS 1 (LEJ1); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: biological_process unknown; LOCATED IN: chloroplast stroma, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cystathionine beta-synthase, core (InterPro:IPR000644); BEST Arabidopsis thaliana protein match is: Cystathionine beta-synthase (CBS) family protein (TAIR:AT4G36910.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      16340907..16343118
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119573.5 → NP_567952.1  Cystathionine beta-synthase (CBS) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567952.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49493, Q9C5D0
      UniProtKB/TrEMBL
      A0A178V5S0, A0A5S9XYG8, A0A654FVT3
      Conserved Domains (1) summary
      cd17789
      Location:85 → 226
      CBS_pair_plant_CBSX; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains from plant CBSX proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C5D0.1

    Gene LinkOut

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