AGB1 GTP binding protein beta 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: AGB1
Official Full Name: GTP binding protein beta 1
Primary source: TAIR:AT4G34460
Locus tag: AT4G34460
See related: Araport:AT4G34460
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS G-PROTEIN BETA SUBUNIT; ATAGB1; ELK4; ERECTA-LIKE 4; GTP binding protein beta 1; T4L20.40; T4L20_40
Summary: Encodes the heterotrimeric G-protein beta subunit and is involved in organ shape. A significant fraction of the protein is found in the ER. Mutants carrying null alleles express similar fruit phenotypes, as seen in er plants, but differ from er in that the stem is only slightly shorter than that in the wild type, the pedicel is slightly longer than that in the wild type, and the leaves are rounder than those in er mutants. Gene is expressed in all tissues examined, with highest expression level found in siliques. It is involved in resistance to Plectosphaerella cucumerina. The predicted protein has two DWD motifs. It can bind to DDB1a in Y2H assays and may be involved in the formation of a CUL4-based E3 ubiquitin ligase. It seems to be involved in the calcium-mediated response to extracellular ATP.
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Genomic context

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See AGB1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 6

Sequence:: Chromosome: 4; NC_003075.7 (16477031..16479620, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arabidopsis G-protein beta subunit AGB1 represses abscisic acid signaling via attenuation of the MPK3-VIP1 phosphorylation cascade.
Title: Arabidopsis G-protein β subunit AGB1 represses abscisic acid signaling via attenuation of the MPK3-VIP1 phosphorylation cascade.
Arabidopsis cryptochrome 1 promotes stomatal development through repression of AGB1 inhibition of SPEECHLESS DNA-binding activity.
Title: Arabidopsis cryptochrome 1 promotes stomatal development through repression of AGB1 inhibition of SPEECHLESS DNA-binding activity.
Arabidopsis G-Protein beta Subunit AGB1 Negatively Regulates DNA Binding of MYB62, a Suppressor in the Gibberellin Pathway.
Title: Arabidopsis G-Protein β Subunit AGB1 Negatively Regulates DNA Binding of MYB62, a Suppressor in the Gibberellin Pathway.
Oligomerization of A. thaliana Heterotrimeric G Protein Subunits AGB1 and AGG2 In Vitro.
Title: Oligomerization of A. thaliana Heterotrimeric G Protein Subunits AGB1 and AGG2 In Vitro.
G-protein signaling via AGB1/AGG1/AGG2 is essential for extracellular Calcium regulation of stomatal apertures.
Title: The Arabidopsis heterotrimeric G-protein β subunit, AGB1, is required for guard cell calcium sensing and calcium-induced calcium release.
phyB and AGB1 antagonistically regulate PIF3 stability by dynamically interacting with each other and PIF3
Title: Phytochrome B and AGB1 Coordinately Regulate Photomorphogenesis by Antagonistically Modulating PIF3 Stability in Arabidopsis.
AGB1 inhibition of photomorphogenesis is mediated, through the repression of the DNA-binding activity of HY5 by the physical AGB1-HY5 interaction, and the mechanism of CRY1 control of photomorphogenesis involves positive regulation of the DNA-binding activity of HY5 by the CRY1--AGB1 interaction, which prevents the association of AGB1 with HY5
Title: Photoexcited CRYPTOCHROME 1 Interacts Directly with G-Protein β Subunit AGB1 to Regulate the DNA-Binding Activity of HY5 and Photomorphogenesis in Arabidopsis.
Inter-relationships with the receptor-like kinase FERONIA and RALF1 in salinity response
Title: Inter-relationships between the heterotrimeric Gβ subunit AGB1, the receptor-like kinase FERONIA, and RALF1 in salinity response.
AGB1 participates in RALF1 control of stomatal movement.
Title: The G Protein β-Subunit, AGB1, Interacts with FERONIA in RALF1-Regulated Stomatal Movement.
Arabidopsis Gbeta protein AGB1 interacts with MPK3 and 6, MKK4 and 5, as well as the regulatory domains of YODA (YDA), the upstream MEKK of MKK4/5.
Title: The integration of Gβ and MAPK signaling cascade in zygote development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001085022.1

Supported by ESTs:

NM_119611.5

Supported by ESTs:

NM_179163.3

Supported by ESTs:

NM_202954.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endoplasmic reticulum unfolded protein response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fruit development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within jasmonic acid mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lateral root development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plant organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of root development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to ATP	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to ethylene	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within root development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within seed germination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stomatal movement	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
part_of heterotrimeric G-protein complex	IDA Inferred from Direct Assay more info	PubMed
part_of heterotrimeric G-protein complex	IPI Inferred from Physical Interaction more info	PubMed
part_of heterotrimeric G-protein complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: GTP binding protein beta 1

NP_001078491.1

GTP binding protein beta 1 (AGB1); FUNCTIONS IN: protein binding, GTPase activity, nucleotide binding; INVOLVED IN: in 11 processes; LOCATED IN: endoplasmic reticulum, plasma membrane, CUL4 RING ubiquitin ligase complex, heterotrimeric G-protein complex; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), Guanine nucleotide-binding protein, beta subunit (InterPro:IPR016346), WD40 repeat (InterPro:IPR001680), G-protein, beta subunit (InterPro:IPR001632), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: WD-40 repeat family protein (TAIR:AT5G67320.1); Has 59918 Blast hits to 28704 proteins in 832 species: Archae - 54; Bacteria - 8355; Metazoa - 23550; Fungi - 12390; Plants - 7677; Viruses - 0; Other Eukaryotes - 7892 (source: NCBI BLink).

NP_195172.1

GTP binding protein beta 1 (AGB1); FUNCTIONS IN: protein binding, GTPase activity, nucleotide binding; INVOLVED IN: in 11 processes; LOCATED IN: endoplasmic reticulum, plasma membrane, CUL4 RING ubiquitin ligase complex, heterotrimeric G-protein complex; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), Guanine nucleotide-binding protein, beta subunit (InterPro:IPR016346), WD40 repeat (InterPro:IPR001680), G-protein beta WD-40 repeat, region (InterPro:IPR020472), G-protein, beta subunit (InterPro:IPR001632), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: WD-40 repeat family protein (TAIR:AT5G67320.1); Has 60281 Blast hits to 28762 proteins in 834 species: Archae - 58; Bacteria - 8505; Metazoa - 23635; Fungi - 12687; Plants - 7683; Viruses - 0; Other Eukaryotes - 7713 (source: NCBI BLink).

NP_849494.2

GTP binding protein beta 1 (AGB1); FUNCTIONS IN: protein binding, GTPase activity, nucleotide binding; INVOLVED IN: in 11 processes; LOCATED IN: endoplasmic reticulum, plasma membrane, CUL4 RING ubiquitin ligase complex, heterotrimeric G-protein complex; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), Guanine nucleotide-binding protein, beta subunit (InterPro:IPR016346), WD40 repeat (InterPro:IPR001680), G-protein, beta subunit (InterPro:IPR001632), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: WD-40 repeat family protein / notchless protein, putative (TAIR:AT5G52820.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NP_974683.1

GTP binding protein beta 1 (AGB1); FUNCTIONS IN: protein binding, GTPase activity, nucleotide binding; INVOLVED IN: in 11 processes; LOCATED IN: endoplasmic reticulum, plasma membrane, CUL4 RING ubiquitin ligase complex, heterotrimeric G-protein complex; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), Guanine nucleotide-binding protein, beta subunit (InterPro:IPR016346), WD40 repeat (InterPro:IPR001680), G-protein, beta subunit (InterPro:IPR001632), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: TBP-associated factor 5 (TAIR:AT5G25150.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

16477031..16479620 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_119611.5 → NP_195172.1 GTP binding protein beta 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_195172.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P49177

UniProtKB/TrEMBL

A0A178V0Y1, A0A5S9Y0S8, A0A654FVJ7

Conserved Domains (2) summary

cd00200
Location:57 → 369

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:68 → 105

7WD40; WD40 repeat [structural motif]
NM_001085022.1 → NP_001078491.1 GTP binding protein beta 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001078491.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A654FVJ7, A8MR96

Conserved Domains (3) summary

COG2319
Location:53 → 363

WD40; WD40 repeat [General function prediction only]

cd00200
Location:52 → 364

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:63 → 100

7WD40; WD40 repeat [structural motif]
NM_202954.3 → NP_974683.1 GTP binding protein beta 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_974683.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A654FVJ7, F4JLD2

Conserved Domains (3) summary

COG2319
Location:57 → 333

WD40; WD40 repeat [General function prediction only]

cd00200
Location:57 → 333

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:68 → 105

7WD40; WD40 repeat [structural motif]
NM_179163.3 → NP_849494.2 GTP binding protein beta 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_849494.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A654FVJ7, F4JLD1

Conserved Domains (3) summary

COG2319
Location:3 → 306

WD40; WD40 repeat [General function prediction only]

cd00200
Location:6 → 307

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:6 → 43

7WD40; WD40 repeat [structural motif]