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    DRL1 dihydroflavonol 4-reductase-like1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829695, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DRL1
    Official Full Name
    dihydroflavonol 4-reductase-like1
    Primary source
    TAIR:AT4G35420
    Locus tag
    AT4G35420
    See related
    Araport:AT4G35420
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    dihydroflavonol 4-reductase-like1; F15J1.1; tetraketide alpha-pyrone reductase 1; TKPR1
    Summary
    Encodes DRL1 (Dihydroflavonol 4-reductase-like1), a closely related homolog of the rice anther-specific gene OsDFR2. DRL1 may be involved in a metabolic pathway essential for pollen wall development and male fertility. Mutant plants have impaired pollen formation and seed production.
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    Genomic context

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    See DRL1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    6
    Sequence:
    Chromosome: 4; NC_003075.7 (16833933..16835619, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene AT-hook protein of GA feedback 1 Neighboring gene pseudo Neighboring gene Clathrin adaptor complex small chain family protein Neighboring gene uncharacterized protein Neighboring gene chloride channel E Neighboring gene ankyrin repeat-containing protein 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An anther-specific dihydroflavonol 4-reductase-like gene (DRL1) is essential for male fertility in Arabidopsis. Tang LK, et al. New Phytol, 2009. PMID 19054337
    2. Analysis of TETRAKETIDE α-PYRONE REDUCTASE function in Arabidopsis thaliana reveals a previously unknown, but conserved, biochemical pathway in sporopollenin monomer biosynthesis. Grienenberger E, et al. Plant Cell, 2010 Dec. PMID 21193572, Free PMC Article
    3. Sporopollenin biosynthetic enzymes interact and constitute a metabolon localized to the endoplasmic reticulum of tapetum cells. Lallemand B, et al. Plant Physiol, 2013 Jun. PMID 23632852, Free PMC Article
    4. A large-scale genetic screen in Arabidopsis to identify genes involved in pollen exine production. Dobritsa AA, et al. Plant Physiol, 2011 Oct. PMID 21849515, Free PMC Article
    5. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DRL1 may have a conserved functional role in male fertility in flowering plants. [DRL1]
      Title: An anther-specific dihydroflavonol 4-reductase-like gene (DRL1) is essential for male fertility in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_119708.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within pollen development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen exine formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within seed development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sporopollenin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dihydroflavonol 4-reductase-like1
    NP_195268.2
    • dihydroflavonol 4-reductase-like1 (DRL1); FUNCTIONS IN: coenzyme binding, binding, catalytic activity; INVOLVED IN: seed development, pollen development; LOCATED IN: endomembrane system; EXPRESSED IN: leaf whorl, hypocotyl, sepal, flower, seed; EXPRESSED DURING: petal differentiation and expansion stage, E expanded cotyledon stage; CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: NAD(P)-binding Rossmann-fold superfamily protein (TAIR:AT1G68540.1); Has 11019 Blast hits to 11006 proteins in 1795 species: Archae - 197; Bacteria - 4697; Metazoa - 293; Fungi - 927; Plants - 2536; Viruses - 49; Other Eukaryotes - 2320 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      16833933..16835619 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119708.3 → NP_195268.2  dihydroflavonol 4-reductase-like1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195268.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65487, Q500U8
      UniProtKB/TrEMBL
      A0A178UY38, A0A5S9XYU6, A0A654FW88
      Conserved Domains (1) summary
      cd08958
      Location:8 → 299
      FR_SDR_e; flavonoid reductase (FR), extended (e) SDRs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q500U8.1

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