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    NRPB1 RNA polymerase II large subunit [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829734, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NRPB1
    Official Full Name
    RNA polymerase II large subunit
    Primary source
    TAIR:AT4G35800
    Locus tag
    AT4G35800
    See related
    Araport:AT4G35800
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F4B14.70; F4B14_70; RNA polymerase II large subunit; RNA POLYMERASE II LARGE SUBUNIT; RNA_POL_II_LS; RNA_POL_II_LSRNA_POL_II_LS; RPB1
    Summary
    Encodes the unique largest subunit of nuclear DNA-dependent RNA polymerase II; the ortholog of budding yeast RPB1 and a homolog of the E. coli RNA polymerase beta prime subunit.
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    Genomic context

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    See NRPB1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    14
    Sequence:
    Chromosome: 4; NC_003075.7 (16960558..16968128, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene phospholipase D delta Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of the genes encoding the largest subunit of RNA polymerase II in Arabidopsis and soybean. Dietrich MA, et al. Plant Mol Biol, 1990 Aug. PMID 2103447
    2. Intact Arabidopsis RPB1 functions in stem cell niches maintenance and cell cycling control. Zhang QQ, et al. Plant J, 2018 Jul. PMID 29752751
    3. Full-length RPB1 is required in two-step shoot regeneration. Li Y, et al. Biochem Biophys Res Commun, 2018 May 23. PMID 29625106
    4. The mutation nrpb1-A325V in the largest subunit of RNA polymerase II suppresses compromised growth of Arabidopsis plants deficient in a function of the general transcription factor IIF. Babiychuk E, et al. Plant J, 2017 Feb. PMID 27862530
    5. The 5'UTR Intron of Arabidopsis GGT1 Aminotransferase Enhances Promoter Activity by Recruiting RNA Polymerase II. Laxa M, et al. Plant Physiol, 2016 Sep. PMID 27418588, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. functions in stem cell niches maintenance and cell cycling control
      Title: Intact Arabidopsis RPB1 functions in stem cell niches maintenance and cell cycling control.
    2. RNA polymerase II read through depends on the expression of the genes in SAL1-XRN2-XRN3 signaling.SAL1, XRN2, and XRN3 affect RNA polymerase II termination.
      Title: RNA Polymerase II Read-Through Promotes Expression of Neighboring Genes in SAL1-PAP-XRN Retrograde Signaling.
    3. RPB1 is required for shoot regeneration.
      Title: Full-length RPB1 is required in two-step shoot regeneration.
    4. The mutation nrpb1-A325V in the largest subunit of RNA polymerase II suppresses compromised growth of Arabidopsis plants deficient in a function of the general transcription factor IIF
      Title: The mutation nrpb1-A325V in the largest subunit of RNA polymerase II suppresses compromised growth of Arabidopsis plants deficient in a function of the general transcription factor IIF.
    5. Data indicate that intron-mediated enhancement (IME) of the GGT1 5'UTR intron is controlled on the transcriptional level, and that the abundance of RNA polymerase II binding to the intron-less construct is reduced.
      Title: The 5'UTR Intron of Arabidopsis GGT1 Aminotransferase Enhances Promoter Activity by Recruiting RNA Polymerase II.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001342374.1
    NM_119746.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-directed 5'-3' RNA polymerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II, core complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type vacuole HDA PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    RNA polymerase II large subunit
    NP_195305.2
    • RNA polymerase II large subunit (NRPB1); FUNCTIONS IN: DNA-directed RNA polymerase activity, DNA binding; INVOLVED IN: transcription, transcription from RNA polymerase II promoter; LOCATED IN: nucleus, chloroplast, DNA-directed RNA polymerase II, core complex, vacuole; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: RNA polymerase, N-terminal (InterPro:IPR006592), RNA polymerase, alpha subunit (InterPro:IPR000722), RNA polymerase II, heptapeptide repeat, eukaryotic (InterPro:IPR000684), RNA polymerase Rpb1, domain 7 (InterPro:IPR007073), RNA polymerase Rpb1, domain 3 (InterPro:IPR007066), RNA polymerase Rpb1, domain 1 (InterPro:IPR007080), RNA polymerase Rpb1, domain 4 (InterPro:IPR007083), RNA polymerase Rpb1, domain 5 (InterPro:IPR007081), RNA polymerase Rpb1, domain 6 (InterPro:IPR007075); BEST Arabidopsis thaliana protein match is: nuclear RNA polymerase C1 (TAIR:AT5G60040.1); Has 181834 Blast hits to 82224 proteins in 9254 species: Archae - 731; Bacteria - 33255; Metazoa - 56600; Fungi - 34284; Plants - 19037; Viruses - 3576; Other Eukaryotes - 34351 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      16960558..16968128 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119746.4 → NP_195305.2  RNA polymerase II large subunit [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195305.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P18616, P31635, Q56Z04, Q9SZS8
      UniProtKB/TrEMBL
      A0A178UYS0, A0A5S9XZE2, A0A7G2FA94
      Conserved Domains (3) summary
      cd02584
      Location:1055 → 1467
      RNAP_II_Rpb1_C; Largest subunit (Rpb1) of Eukaryotic RNA polymerase II (RNAP II), C-terminal domain
      cd02733
      Location:18 → 872
      RNAP_II_RPB1_N; Largest subunit (Rpb1) of eukaryotic RNA polymerase II (RNAP II), N-terminal domain
      pfam04992
      Location:892 → 1076
      RNA_pol_Rpb1_6; RNA polymerase Rpb1, domain 6

    2. NM_001342374.1 → NP_001329346.1  RNA polymerase II large subunit [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P18616, P31635, Q56Z04, Q9SZS8
      UniProtKB/TrEMBL
      A0A178UYS0, A0A5S9XZE2, A0A7G2FA94
      Conserved Domains (3) summary
      cd02584
      Location:1055 → 1467
      RNAP_II_Rpb1_C; Largest subunit (Rpb1) of Eukaryotic RNA polymerase II (RNAP II), C-terminal domain
      cd02733
      Location:18 → 872
      RNAP_II_RPB1_N; Largest subunit (Rpb1) of eukaryotic RNA polymerase II (RNAP II), N-terminal domain
      pfam04992
      Location:892 → 1076
      RNA_pol_Rpb1_6; RNA polymerase Rpb1, domain 6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18616.3

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