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    AAE3 AMP-dependent synthetase and ligase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824060, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AAE3
    Official Full Name
    AMP-dependent synthetase and ligase family protein
    Primary source
    TAIR:AT3G48990
    Locus tag
    AT3G48990
    See related
    Araport:AT3G48990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ACYL-ACTIVATING ENZYME 3
    Summary
    Encodes an oxalyl-CoA synthetase and is required for oxalate degradation, for normal seed development, and for defense against an oxalate-producing fungal pathogen.
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    Genomic context

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    See AAE3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    5
    Sequence:
    Chromosome: 3; NC_003074.8 (18158565..18161486, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Heavy metal transport/detoxification superfamily protein Neighboring gene O-glucosyltransferase rumi-like protein (DUF821) Neighboring gene RNA polymerase III subunit RPC82 family protein Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption of the Arabidopsis Acyl-Activating Enzyme 3 Impairs Seed Coat Mucilage Accumulation and Seed Germination. Cheng N, et al. Int J Mol Sci, 2024 Jan 17. PMID 38256222, Free PMC Article
    2. A previously unknown oxalyl-CoA synthetase is important for oxalate catabolism in Arabidopsis. Foster J, et al. Plant Cell, 2012 Mar. PMID 22447686, Free PMC Article
    3. Redox Conformation-Specific Protein-Protein Interactions of the 2-Cysteine Peroxiredoxin in Arabidopsis. Liebthal M, et al. Antioxidants (Basel), 2020 Jun 11. PMID 32545358, Free PMC Article
    4. Hydroponic isotope labelling of entire plants (HILEP) for quantitative plant proteomics; an oxidative stress case study. Bindschedler LV, et al. Phytochemistry, 2008 Jul. PMID 18538804
    5. Novel Aquaporin Regulatory Mechanisms Revealed by Interactomics. Bellati J, et al. Mol Cell Proteomics, 2016 Nov. PMID 27609422, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Disruption of the Arabidopsis Acyl-Activating Enzyme 3 Impairs Seed Coat Mucilage Accumulation and Seed Germination.
      Title: Disruption of the Arabidopsis Acyl-Activating Enzyme 3 Impairs Seed Coat Mucilage Accumulation and Seed Germination.
    2. Oxalyl-CoA synthetase is required for oxalate degradation, for normal seed development, and for defense against an oxalate-producing fungal pathogen.
      Title: A previously unknown oxalyl-CoA synthetase is important for oxalate catabolism in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_114758.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables oxalate-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within oxalate catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of seed germination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within seed coat development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apoplast HDA PubMed 
    located_in chloroplast HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    AMP-dependent synthetase and ligase family protein
    NP_190468.1
    • AMP-dependent synthetase and ligase family protein; FUNCTIONS IN: catalytic activity, AMP binding; INVOLVED IN: response to cadmium ion; LOCATED IN: apoplast, chloroplast; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: AMP-binding, conserved site (InterPro:IPR020845), AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: AMP-dependent synthetase and ligase family protein (TAIR:AT4G05160.1); Has 84840 Blast hits to 77127 proteins in 3761 species: Archae - 1146; Bacteria - 54375; Metazoa - 3415; Fungi - 4706; Plants - 2571; Viruses - 1; Other Eukaryotes - 18626 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      18158565..18161486 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_114758.5 → NP_190468.1  AMP-dependent synthetase and ligase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190468.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8L9Z5, Q9SMT7
      UniProtKB/TrEMBL
      A0A178V7A3, A0A5S9XJ86, A0A654FE46
      Conserved Domains (1) summary
      cd05926
      Location:18 → 508
      FACL_fum10p_like; Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SMT7.1

    Gene LinkOut

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