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    ABCB21 P-glycoprotein 21 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825388, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ABCB21
    Official Full Name
    P-glycoprotein 21
    Primary source
    TAIR:AT3G62150
    Locus tag
    AT3G62150
    See related
    Araport:AT3G62150
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATP-binding cassette B21; P-glycoprotein 21; PGP21
    Summary
    Encodes a facultative transporter controlling auxin concentrations in plant cells.
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    Genomic context

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    See ABCB21 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    11
    Sequence:
    Chromosome: 3; NC_003074.8 (23008653..23014030, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Class II aaRS and biotin synthetases superfamily protein Neighboring gene Pyridoxal phosphate (PLP)-dependent transferases superfamily protein Neighboring gene NEFA-interacting nuclear protein Neighboring gene HXXXD-type acyl-transferase family protein Neighboring gene VANGUARD-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis ABCB21 is a facultative auxin importer/exporter regulated by cytoplasmic auxin concentration. Kamimoto Y, et al. Plant Cell Physiol, 2012 Dec. PMID 23147222
    2. Large-scale analysis of in vivo phosphorylated membrane proteins by immobilized metal ion affinity chromatography and mass spectrometry. Nühse TS, et al. Mol Cell Proteomics, 2003 Nov. PMID 14506206
    3. A proteomics dissection of Arabidopsis thaliana vacuoles isolated from cell culture. Jaquinod M, et al. Mol Cell Proteomics, 2007 Mar. PMID 17151019, Free PMC Article
    4. A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome. Marmagne A, et al. Mol Cell Proteomics, 2007 Nov. PMID 17644812
    5. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ABCB21 functions as a facultative importer/exporter controlling auxin concentrations in plant cells.
      Title: Arabidopsis ABCB21 is a facultative auxin importer/exporter regulated by cytoplasmic auxin concentration.
    Submit: New GeneRIF Correction

    General gene information

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    NM_116080.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables auxin efflux transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables auxin influx transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within auxin export across the plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within auxin import into cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type vacuole HDA PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    P-glycoprotein 21
    NP_191774.2
    • P-glycoprotein 21 (PGP21); FUNCTIONS IN: ATPase activity, coupled to transmembrane movement of substances; INVOLVED IN: transport, transmembrane transport; LOCATED IN: plasma membrane; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ABC transporter-like (InterPro:IPR003439), ABC transporter, transmembrane domain, type 1 (InterPro:IPR011527), ABC transporter integral membrane type 1 (InterPro:IPR017940), ABC transporter, transmembrane domain (InterPro:IPR001140), ABC transporter, conserved site (InterPro:IPR017871); BEST Arabidopsis thaliana protein match is: ATP binding cassette subfamily B4 (TAIR:AT2G47000.1); Has 850676 Blast hits to 393228 proteins in 4171 species: Archae - 14744; Bacteria - 664075; Metazoa - 17906; Fungi - 12823; Plants - 9925; Viruses - 47; Other Eukaryotes - 131156 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      23008653..23014030 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001340142.1 → NP_001327193.1  P-glycoprotein 21 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1I9LRJ8, F4IX45, Q9M1Q9
      UniProtKB/TrEMBL
      A0A178V514, A0A5S9XNQ2, A0A654FJZ1
      Conserved Domains (1) summary
      PTZ00265
      Location:16 → 1290
      PTZ00265; multidrug resistance protein (mdr1); Provisional

    2. NM_001340143.1 → NP_001327192.1  P-glycoprotein 21 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1I9LRJ8, F4IX45, Q9M1Q9
      UniProtKB/TrEMBL
      A0A178V514, A0A5S9XNQ2, A0A654FJZ1
      Conserved Domains (1) summary
      PTZ00265
      Location:16 → 1290
      PTZ00265; multidrug resistance protein (mdr1); Provisional

    3. NM_116080.3 → NP_191774.2  P-glycoprotein 21 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191774.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1I9LRJ8, F4IX45, Q9M1Q9
      UniProtKB/TrEMBL
      A0A178V514, A0A5S9XNQ2, A0A654FJZ1
      Conserved Domains (1) summary
      PTZ00265
      Location:16 → 1290
      PTZ00265; multidrug resistance protein (mdr1); Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M1Q9.2

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