SIM cyclin-dependent protein kinase inhibitor [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: SIM
Official Full Name: cyclin-dependent protein kinase inhibitor
Primary source: TAIR:AT5G04470
Locus tag: AT5G04470
See related: Araport:AT5G04470
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: SIAMESE; T19N18.8
Summary: Encodes a novel nuclear 14-kD protein containing a cyclin binding motif and a motif found in ICK/KRP cell cycle inhibitor proteins. It is required for coordinating cell division and cell differentiation during the development of Arabidopsis trichomes, playing a key role in the mitosis-to-endoreduplication transition. It interacts with D-type cyclins in vivo.
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Genomic context

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See SIM in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 1

Sequence:: Chromosome: 5; NC_003076.8 (1266625..1267416, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sim protein has phosphorylation site and two redundant nuclear localization sequences.
Title: Functional Analysis of Short Linear Motifs in the Plant Cyclin-Dependent Kinase Inhibitor SIAMESE.
SIM role in regulating cell-cycle progression and innate immunity
Title: Differential Roles of Two Homologous Cyclin-Dependent Kinase Inhibitor Genes in Regulating Cell Cycle and Innate Immunity in Arabidopsis.
SIM and SMR1 are involved in hyperphosphorylation of the cell-cycle regulator RBR1 and overexpression of E2F target genes.
Title: A noncanonical role for the CKI-RB-E2F cell-cycle signaling pathway in plant effector-triggered immunity.
GIS may play an indirect role in regulating trichome cell division by genetically interacting with SIM
Title: GLABROUS INFLORESCENCE STEMS regulates trichome branching by genetically interacting with SIM in Arabidopsis.
CCS52A1 and SIM cooperate in repressing accumulation of mitotic cyclins to establish the trichome endocycle.
Title: SIAMESE cooperates with the CDH1-like protein CCS52A1 to establish endoreplication in Arabidopsis thaliana trichomes.
The analysis of genes preferentially expressed in gl3-sst sim double mutant led to the identification of four additional genes required for normal trichome development.
Title: Transcriptome analysis of Arabidopsis wild-type and gl3-sst sim trichomes identifies four additional genes required for trichome development.
A novel interaction between mutant alleles of two genes, gl3-sst derived from GL3, and SIM exhibits mounds of cells derived from the proliferation of single trichome precursors. [SIAMESE] [SIM]
Title: Genetic interaction between glabra3-shapeshifter and siamese in Arabidopsis thaliana converts trichome precursors into cells with meristematic activity.
SIM encodes a plant-specific CDK (Cyclin dependent kinase) inhibitor with a key function in the mitosis-to-endoreplication transition. [SIAMESE] [SIM]
Title: SIAMESE, a plant-specific cell cycle regulator, controls endoreplication onset in Arabidopsis thaliana.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_120529.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase inhibitor activity	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA endoreduplication	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of mitotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA endoreduplication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within trichome differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: cyclin-dependent protein kinase inhibitor

NP_196067.1

SIAMESE (SIM); BEST Arabidopsis thaliana protein match is: LOSS OF GIANT CELLS FROM ORGANS (TAIR:AT3G10525.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).