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    TFL2 uncharacterized protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831635, updated on 2-Oct-2024

    Summary

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    Official Symbol
    TFL2
    Official Full Name
    uncharacterized protein
    Primary source
    TAIR:AT5G17690
    Locus tag
    AT5G17690
    See related
    Araport:AT5G17690
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtLHP1; LHP1; LIKE HETEROCHROMATIN PROTEIN 1; MVA3.4; MVA3_4; TERMINAL FLOWER 2
    Summary
    Regulates the meristem response to light signals and the maintenance of inflorescence meristem identity. Influences developmental processes controlled by APETALA1. TFL2 silences specific genes within euchromatin but not genes positioned in heterochromatin. TFL2 protein localized preferentially to euchromatic regions and not to heterochromatic chromocenters. Involved in euchromatin organization. Required for epigenetic maintenance of the vernalized state.
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    Genomic context

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    See TFL2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (5827142..5829763, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene glycine/proline-rich protein Neighboring gene tRNA (guanine-N-7) methyltransferase Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene disease resistance protein (TIR-NBS-LRR class) Neighboring gene MATE efflux family protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DamID, a new tool for studying plant chromatin profiling in vivo, and its use to identify putative LHP1 target loci. Germann S, et al. Plant J, 2006 Oct. PMID 16972870
    2. Arabidopsis thaliana TERMINAL FLOWER2 is involved in light-controlled signalling during seedling photomorphogenesis. Valdés AE, et al. Plant Cell Environ, 2012 Jun. PMID 22145973
    3. TFL2/LHP1 is involved in auxin biosynthesis through positive regulation of YUCCA genes. Rizzardi K, et al. Plant J, 2011 Mar. PMID 21251106
    4. LHP1 Regulates H3K27me3 Spreading and Shapes the Three-Dimensional Conformation of the Arabidopsis Genome. Veluchamy A, et al. PLoS One, 2016. PMID 27410265, Free PMC Article
    5. The Arabidopsis LHP1 protein colocalizes with histone H3 Lys27 trimethylation. Zhang X, et al. Nat Struct Mol Biol, 2007 Sep. PMID 17676062

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LIKE HETEROCHROMATIN PROTEIN 1 (LHP1) partially inhibits the transcriptional activation of FT by MYB73 and regulates flowering in Arabidopsis.
      Title: LIKE HETEROCHROMATIN PROTEIN 1 (LHP1) partially inhibits the transcriptional activation of FT by MYB73 and regulates flowering in Arabidopsis.
    2. Interaction of ubiquitin-like protein SILENCING DEFECTIVE 2 with LIKE HETEROCHROMATIN PROTEIN 1 is required for regulation of anthocyanin biosynthesis in Arabidopsis thaliana in response to sucrose.
      Title: Interaction of ubiquitin-like protein SILENCING DEFECTIVE 2 with LIKE HETEROCHROMATIN PROTEIN 1 is required for regulation of anthocyanin biosynthesis in Arabidopsis thaliana in response to sucrose.
    3. SUMO protease FUG1, histone reader AL3 and chromodomain protein LHP1 are integral to repeat expansion-induced gene silencing in Arabidopsis thaliana.
      Title: SUMO protease FUG1, histone reader AL3 and chromodomain protein LHP1 are integral to repeat expansion-induced gene silencing in Arabidopsis thaliana.
    4. Structural basis for the recognition of methylated histone H3 by the Arabidopsis LHP1 chromodomain.
      Title: Structural basis for the recognition of methylated histone H3 by the Arabidopsis LHP1 chromodomain.
    5. Nuclear import of LIKE HETEROCHROMATIN PROTEIN1 is redundantly mediated by importins alpha-1, alpha-2 and alpha-3.
      Title: Nuclear import of LIKE HETEROCHROMATIN PROTEIN1 is redundantly mediated by importins α-1, α-2 and α-3.
    6. Arabidopsis PEAPODs function with LIKE HETEROCHROMATIN PROTEIN1 to regulate lateral organ growth.
      Title: Arabidopsis PEAPODs function with LIKE HETEROCHROMATIN PROTEIN1 to regulate lateral organ growth.
    7. EOL1 interacts with LHP1-PRC2 complexes during replication and thereby participates in maintaining the H3K27me3 mark at target genes.
      Title: Ctf4-related protein recruits LHP1-PRC2 to maintain H3K27me3 levels in dividing cells in Arabidopsis thaliana.
    8. a general role of LHP1 from local to higher conformation levels of chromatin configuration to determine its accessibility to define gene expression patterns
      Title: LHP1 Regulates H3K27me3 Spreading and Shapes the Three-Dimensional Conformation of the Arabidopsis Genome.
    9. Neither PRC2 activity nor LHP1 function are a major determinant for H2A monoubiquitination in Arabidopsis thaliana.
      Title: H2A monoubiquitination in Arabidopsis thaliana is generally independent of LHP1 and PRC2 activity.
    10. that complexes of the transcription factors ASYMMETRIC LEAVES 1 (AS1) and AS2 could help to establish the H3K27me3 modification at the chromatin regions of Class-I KNOTTED1-like homeobox (KNOX) genes BREVIPEDICELLUS and KNAT2 via direct interactions with LHP1.
      Title: Transcription factors AS1 and AS2 interact with LHP1 to repress KNOX genes in Arabidopsis.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001343518.1
    NM_001343519.1
    NM_121775.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    NOT enables 3,4-dihydroxy-2-butanone-4-phosphate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP cyclohydrolase II activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables methylated histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heterochromatin formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within multidimensional cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of gene expression, epigenetic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within photoperiodism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within photoperiodism, flowering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to sucrose IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    NOT involved_in root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within shoot system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vernalization response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in euchromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    NP_001330016.1
    • like heterochromatin protein (LHP1)
    NP_001330017.1
    • like heterochromatin protein (LHP1)
    NP_197271.1
    • TERMINAL FLOWER 2 (TFL2); CONTAINS InterPro DOMAIN/s: Chromo domain subgroup (InterPro:IPR017984), Chromo domain-like (InterPro:IPR016197), Chromo shadow, subgroup (InterPro:IPR018125), Chromo domain (InterPro:IPR000953); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).; like heterochromatin protein (LHP1)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      5827142..5829763 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121775.3 → NP_197271.1  uncharacterized protein AT5G17690 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197271.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q946J8, Q9FN82
      UniProtKB/TrEMBL
      A0A5S9Y7B5, Q058P7
      Conserved Domains (2) summary
      smart00298
      Location:107 → 156
      CHROMO; Chromatin organization modifier domain
      cd00034
      Location:385 → 442
      ChSh; Chromo Shadow Domain, found in association with N-terminal chromo (CHRromatin Organization MOdifier) domain; Chromo domains mediate the interaction of the heterochromatin with other heterochromatin proteins, thereby affecting chromatin structure (e.g. ...

    2. NM_001343518.1 → NP_001330017.1  uncharacterized protein AT5G17690 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B9G6, A0A5S9Y7B5

    3. NM_001343519.1 → NP_001330016.1  uncharacterized protein AT5G17690 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UDN2, A0A1P8B9H0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q946J8.2

    Gene LinkOut

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